Abstract
Oropharynx tumors (OPC) comprise 24% of all head and neck malignancies, of which the majority arise from the base of the tongue or tonsils [1–4]. Smoking and alcohol use continue to be major risk factors but the prevalence of human papillomavirus (HPV)-associated oropharyngeal cancer has steadily increased by over 200% since the late 1980s [5]. Definitive management involves surgery or radiation therapy (RT) alone for node-negative early-stage tumors or concurrent chemoradiotherapy (CRT) for nodal involvement or locally advanced disease. In surgically managed cases, adjuvant RT or CRT is also often indicated for extracapsular extension or positive surgical margins.
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Cohan DM, Popat S, Kaplan SE, Rigual N, Loree T, Hicks WL Jr. Oropharyngeal cancer: current understanding and management. Curr Opin Otolaryngol Head Neck Surg. 2009;17(2):88–94.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.
Gunn GB, Debnam JM, Fuller CD, et al. The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Cancer. 2013;119(17):3162–9.
Viens LJ, Henley SJ, Watson M, et al. Human papillomavirus-associated cancers––United States, 2008–2012. MMWR Morb Mortal Wkly Rep. 2016;65(26):661–6.
Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29(32):4294–301.
Cozzi L, Fogliata A, Lomax A, Bolsi A. A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours. Radiother Oncol. 2001;61(3):287–97.
Holliday EB, Kocak-Uzel E, Feng L, et al. Dosimetric advantages of intensity-modulated proton therapy for oropharyngeal cancer compared with intensity-modulated radiation: a case-matched control analysis. Med Dosim. 2016;41:189–94.
van de Water TA, Lomax AJ, Bijl HP, et al. Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2011;79(4):1216–24.
Slater JD, Yonemoto LT, Mantik DW, et al. Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique. Int J Radiat Oncol Biol Phys. 2005;62(2):494–500.
Gunn GB, Blanchard P, Garden AS, et al. Clinical outcomes and patterns of disease recurrence after intensity modulated proton therapy for oropharyngeal squamous carcinoma. Int J Radiat Oncol Biol Phys. 2016;95(1):360–7.
Steneker M, Lomax A, Schneider U. Intensity modulated photon and proton therapy for the treatment of head and neck tumors. Radiother Oncol. 2006;80(2):263–7.
van de Water TA, Lomax AJ, Bijl HP, Schilstra C, Hug EB, Langendijk JA. Using a reduced spot size for intensity-modulated proton therapy potentially improves salivary gland-sparing in oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2012;82(2):e313–9.
Blanchard P, Garden AS, Gunn GB, et al. Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer––a case matched analysis. Radiother Oncol. 2016;120(1):48–55.
Sio TT, Lin HK, Shi Q, et al. Intensity modulated proton therapy versus intensity modulated photon radiation therapy for oropharyngeal cancer: first comparative results of patient-reported outcomes. Int J Radiat Oncol Biol Phys. 2016;95(4):1107–14.
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Patel, S.H., Xu, A.J., Sine, K., Lee, N.Y., Fox, P. (2018). Oropharyngeal Cancer. In: Lee, N., et al. Target Volume Delineation and Treatment Planning for Particle Therapy. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42478-1_6
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DOI: https://doi.org/10.1007/978-3-319-42478-1_6
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