Skip to main content

Primary Spine Tumors

  • Chapter
  • First Online:

Part of the book series: Practical Guides in Radiation Oncology ((PGRO))

This is a preview of subscription content, log in via an institution.

References

  1. Emami B, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21:109–22.

    Article  CAS  PubMed  Google Scholar 

  2. Newhauser WD, Zhang R. The physics of proton therapy. Phys Med Biol. 2015;60:R155–209.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Mitin T, Zietman AL. Promise and pitfalls of heavy-particle therapy. J Clin Oncol Off J Am Soc Clin Oncol. 2014;32:2855–63.

    Article  Google Scholar 

  4. DeLaney TF. Proton therapy in the clinic. Front Radiat Ther Oncol. 2011;43:465–85.

    Article  PubMed  Google Scholar 

  5. McGowan SE, Burnet NG, Lomax AJ. Treatment planning optimisation in proton therapy. Br J Radiol. 2013;86:20120288.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Paganetti H, van Luijk P. Biological considerations when comparing proton therapy with photon therapy. Semin Radiat Oncol. 2013;23:77–87.

    Article  PubMed  Google Scholar 

  7. Paganetti H. Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Phys Med Biol. 2014;59:R419–72.

    Article  PubMed  Google Scholar 

  8. Tommasino F, Durante M. Proton radiobiology. Cancers. 2015;7:353–81.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Engelsman M, Schwarz M, Dong L. Physics controversies in proton therapy. Semin Radiat Oncol. 2013;23:88–96.

    Article  PubMed  Google Scholar 

  10. Paganetti H. Significance and implementation of RBE variations in proton beam therapy. Technol Cancer Res Treat. 2003;2:413–26.

    Article  CAS  PubMed  Google Scholar 

  11. Underwood T, Paganetti H. Variable proton relative biological effectiveness: how do we move forward? Int J Radiat Oncol Biol Phys. 2016;95:56–8.

    Article  PubMed  Google Scholar 

  12. Verburg JM, Seco J. Dosimetric accuracy of proton therapy for chordoma patients with titanium implants. Med Phys. 2013;40:071727.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Paganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012;57:R99–117.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. De Ruysscher D, Sterpin E, Haustermans K, Depuydt T. Tumour movement in proton therapy: solutions and remaining questions: a review. Cancers. 2015;7:1143–53.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Miralbell R, Lomax A, Cella L, Schneider U. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys. 2002;54:824–9.

    Article  PubMed  Google Scholar 

  16. Hug EB, Fitzek MM, Liebsch NJ, Munzenrider JE. Locally challenging osteo- and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning. Int J Radiat Oncol Biol Phys. 1995;31:467–76.

    Article  CAS  PubMed  Google Scholar 

  17. Hug EB, et al. Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neuro-Oncol. 2000;48:151–60.

    Article  CAS  Google Scholar 

  18. Boskos C, et al. Combined proton and photon conformal radiotherapy for intracranial atypical and malignant meningioma. Int J Radiat Oncol Biol Phys. 2009;75:399–406.

    Article  PubMed  Google Scholar 

  19. Chan AW, Bernstein KD, Adams JA, Parambi RJ, Loeffler JS. Dose escalation with proton radiation therapy for high-grade meningiomas. Technol Cancer Res Treat. 2012;11:607–14.

    Article  CAS  PubMed  Google Scholar 

  20. Arvold ND, et al. Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. Int J Radiat Oncol Biol Phys. 2012;83:e495–500.

    Article  PubMed  Google Scholar 

  21. Weber DC, et al. Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicity. Neurosurgery. 2003;53:577–86. discussion 586–8

    Article  PubMed  Google Scholar 

  22. George B, Bresson D, Herman P, Froelich S. Chordomas: a review. Neurosurg Clin N Am. 2015;26:437–52.

    Article  PubMed  Google Scholar 

  23. Fuchs B, Dickey ID, Yaszemski MJ, Inwards CY, Sim FH. Operative management of sacral chordoma. J Bone Joint Surg Am. 2005;87:2211–6.

    PubMed  Google Scholar 

  24. Osaka S, Osaka E, Kojima T, Yoshida Y, Tokuhashi Y. Long-term outcome following surgical treatment of sacral chordoma. J Surg Oncol. 2014;109:184–8.

    Article  PubMed  Google Scholar 

  25. Ruggieri P, Angelini A, Ussia G, Montalti M, Mercuri M. Surgical margins and local control in resection of sacral chordomas. Clin Orthop Relat Res. 2010;468:2939–47.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Yamada Y, et al. Preliminary results of high-dose single-fraction radiotherapy for the management of chordomas of the spine and sacrum. Neurosurgery. 2013;73:673–80. discussion 680

    Article  PubMed  Google Scholar 

  27. Sahgal A, et al. Image-guided, intensity-modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes. Neuro-Oncology. 2015;17:889–94.

    Article  CAS  PubMed  Google Scholar 

  28. Park L, et al. Sacral chordomas: impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006;65:1514–21.

    Article  PubMed  Google Scholar 

  29. Amichetti M, Cianchetti M, Amelio D, Enrici RM, Minniti G. Proton therapy in chordoma of the base of the skull: a systematic review. Neurosurg Rev. 2009;32:403–16.

    Article  PubMed  Google Scholar 

  30. Jahangiri A, et al. Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. Neurosurgery. 2015;76:179–85. discussion 185–176

    Article  PubMed  Google Scholar 

  31. Combs SE, Laperriere N, Brada M. Clinical controversies: proton radiation therapy for brain and skull base tumors. Semin Radiat Oncol. 2013;23:120–6.

    Article  PubMed  Google Scholar 

  32. Talac R, et al. Relationship between surgical margins and local recurrence in sarcomas of the spine. Clin Orthop Relat Res. 2002;397:127–32.

    Article  Google Scholar 

  33. Ozaki T, et al. Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer. 2002;94:1069–77.

    Article  PubMed  Google Scholar 

  34. Wuisman P, Lieshout O, Sugihara S, van Dijk M. Total sacrectomy and reconstruction: oncologic and functional outcome. Clin Orthop Relat Res. 2000;381:192–203.

    Article  Google Scholar 

  35. Ciernik IF, et al. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011;117:4522–30.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Bloch O, Parsa AT. Skull base chondrosarcoma: evidence-based treatment paradigms. Neurosurg Clin N Am. 2013;24:89–96.

    Article  PubMed  Google Scholar 

  37. Rosenberg AE, et al. Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 1999;23:1370–8.

    Article  CAS  PubMed  Google Scholar 

  38. Amichetti M, Amelio D, Cianchetti M, Enrici RM, Minniti G. A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. Neurosurg Rev. 2010;33:155–65.

    Article  PubMed  Google Scholar 

  39. Weber DC, Trofimov AV, Delaney TF, Bortfeld T. A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas. Int J Radiat Oncol Biol Phys. 2004;58:1596–606.

    Article  PubMed  Google Scholar 

  40. Combs SE, Thilmann C, Debus J, Schulz-Ertner D. Precision radiotherapy for hemangiopericytomas of the central nervous system. Cancer. 2005;104:2457–65.

    Article  PubMed  Google Scholar 

  41. Schneider U, et al. The impact of IMRT and proton radiotherapy on secondary cancer incidence. Strahlenther Onkol. 2006;182:647–52.

    Article  PubMed  Google Scholar 

  42. Rombi B, et al. Proton radiotherapy for pediatric Ewing’s sarcoma: initial clinical outcomes. Int J Radiat Oncol Biol Phys. 2012;82:1142–8.

    Article  PubMed  Google Scholar 

  43. Wenkel E, et al. Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. Int J Radiat Oncol Biol Phys. 2000;48:1363–70.

    Article  CAS  PubMed  Google Scholar 

  44. Vernimmen FJ, et al. Stereotactic proton beam therapy of skull base meningiomas. Int J Radiat Oncol Biol Phys. 2001;49:99–105.

    Article  CAS  PubMed  Google Scholar 

  45. Noel G, et al. Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys. 2005;62:1412–22.

    Article  PubMed  Google Scholar 

  46. Pasquier D, et al. Atypical and malignant meningioma: outcome and prognostic factors in 119 irradiated patients. A multicenter, retrospective study of the Rare Cancer Network. Int J Radiat Oncol Biol Phys. 2008;71:1388–93.

    Article  PubMed  Google Scholar 

  47. Santoni R, et al. Temporal lobe (TL) damage following surgery and high-dose photon and proton irradiation in 96 patients affected by chordomas and chondrosarcomas of the base of the skull. Int J Radiat Oncol Biol Phys. 1998;41:59–68.

    Article  CAS  PubMed  Google Scholar 

  48. Terahara A, et al. Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys. 1999;45:351–8.

    Article  CAS  PubMed  Google Scholar 

  49. Hug EB, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 1999;91:432–9.

    Article  CAS  PubMed  Google Scholar 

  50. Colli BO, Al-Mefty O. Chordomas of the skull base: follow-up review and prognostic factors. Neurosurg Focus. 2001;10:E1.

    Article  CAS  PubMed  Google Scholar 

  51. Igaki H, et al. Clinical results of proton beam therapy for skull base chordoma. Int J Radiat Oncol Biol Phys. 2004;60:1120–6.

    Article  PubMed  Google Scholar 

  52. Weber DC, et al. Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institut experience. Int J Radiat Oncol Biol Phys. 2005;63:401–9.

    Article  PubMed  Google Scholar 

  53. Noel G, et al. Radiation therapy for chordoma and chondrosarcoma of the skull base and the cervical spine. Prognostic factors and patterns of failure. Strahlenther Onkol. 2003;179:241–8.

    Article  PubMed  Google Scholar 

  54. Ares C, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75:1111–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anuradha Thiagarajan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Thiagarajan, A., Yamada, Y. (2018). Primary Spine Tumors. In: Lee, N., et al. Target Volume Delineation and Treatment Planning for Particle Therapy. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42478-1_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42478-1_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42477-4

  • Online ISBN: 978-3-319-42478-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics