Abstract
Carbon ion radiation therapy (CIRT) facilities are available in Japan, Germany, and China. The National Institute of Radiological Science (NIRS) and Hyogo Ion Beam Medical Center (HIBMC), both institutions in Japan, have used CIRT to treat hepatocellular carcinoma (HCC) patients, and Heidelberg Ion Beam Therapy Center (HIT) in Germany has treated limited patients. The outcome of CIRT for HCC was been very encouraging. Shanghai Proton and Heavy Ion Center (SPHIC) have started using CIRT for HCC since 2014. In this section, we will address CIRT for HCC.
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References
Liang SX, Zhu XD, Xu ZY, et al. Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys. 2006;65(2):426–34.
Xu ZY, Liang SX, Zhu J, et al. Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma. Int J Radiat Oncol Biol Phys. 2006;65(1):189–95.
Zhao JD, Jiang GL, Hu WG, et al. Hepatocyte regeneration after partial liver irradiation in rats. Exp Toxicol Pathol. 2009;61(5):511–8.
Ren ZG, Zhao JD, Gu K, et al. Hepatic proliferation after partial liver irradiation in rat. Mol Biol Rep. 2012;39(4):3829–36.
Gu K, Lai ST, Ma NY, et al. Hepatic regeneration after sublethal partial liver irradiation in cirrhotic rats. J Radiat Res (Tokyo). 2011;52(5):582–91.
Gu K, Zhao JD, Ren ZG, et al. A natural process of cirrhosis resolution and deceleration of liver regeneration after thioacetamide withdrawal in a rat model. Mol Biol Rep. 2011;38(3):1687–96.
Fokas E, Kraft G, An H, Engenhart-Cabillic R. Ion beam radiobiology and cancer: time to update ourselves. Biochim Biophys Acta. 1796;2009:216–29.
Allen C, Borak TB, Tsujii H, et al. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy. Mutat Res. 2011;711:150–7.
Furusawa Y. The characteristics of carbon ion radiotherapy. In: Tsujii H, Kamada T, Shirai T, Noda K, Tsuji H, Karawawa K, editors. Carbon ion radiotherapy. Japan: Springer; 2014. p. 25–37.
Habermehl D, Ilicic K, Dehne S, et al. The relative biological effectiveness for carbon and oxygen ion beams using the raster-scanning technique in hepatocellular carcinoma cell lines. PLoS One. 2014;9(12):e113591.
Bassler N, Toftegaard J, Luhr A, et al. LET-painting increases tumor control probability in hypoxic tumors. Acta Oncol. 2014;53:25–32.
Mori S, Zenklusen S, Inaniwa T, et al. Conformity and robustness of gated rescanned carbon ion pencil beam scanning of liver tumors at NIRS. Radiother Oncol. 2014;111:431–6.
Mori S, Inaniwa T, Furukawa T, et al. Amplitude-based gated phase-controlled rescanning in carbon-ion scanning beam treatment planning under irregular breathing conditions using lung and liver 4DCTs. J Radiat Res. 2014;55:948–58.
Ogata S, Mori S, Yasuda S. Extended phase-correlated rescanning irradiation to improve dose homogeneity in carbon-ion beam liver treatment. Phys Med Biol. 2014;59:5091–9.
Richter D, Graeff C, Jakel O, et al. Residual motion mitigation in scanned carbon ion beam therapy of liver tumors using enlarged pencil beam overlap. Radiother Oncol. 2014;113:290–5.
Kato H, Tsujii H, Miyamoto T, et al. Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. Int J Radiat Oncol Biol Phys. 2004;59(5):1468–76.
Imada H, Kato H, Yasuda S, et al. Conparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis. Radiother Oncol. 2010;96:231–5.
Tsujii H, Kamada T, Shirai T, et al. Carbon-ion radiotherapy: principles, practices, and treatment planning. Japan: Springer; 2014. p. 213–8.
Imada H, Kato H, Yasuda S, et al. Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy - relation to prognosis and liver function. Radiother Oncol. 2010;96:236–42.
Komatsu S, Fukumoto T, Demizu Y, et al. Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma. Cancer. 2011;117(21):4890–904.
Combs SE, Habermehl D, Ganten T, et al. Phase I study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: the PROMETHEUS-01 trail. BMC Cancer. 2011;11:67.
Habermehl D, Debus J, Ganten T, et al. Hypofractionated carbon ion therapy delivered with scanned ion beam for patients with hepatocellular carcinoma - feasibility and clinical response. Radiat Oncol. 2013;8:59.
Steinstrater O, Grun R, Scholz U, et al. Mapping of RBE-weighted doses between HIMAC and LEM based treatment planning system for carbon ion therapy. Int J Radiat Oncol Biol Phys. 2012;84(3):854–60.
Fossati P, Molinelli S, Matsufuji N, et al. Dose prescription in carbon ion radiotherapy: a planning study for compare NIRS and LEM approaches with a clinically-oriented strategy. Phys Med Biol. 2012;57:7543–54.
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Wang, Z., Wang, WW., Shahnazi, K., Jiang, GL. (2018). Carbon Ion Radiation Therapy for Liver Tumors. In: Lee, N., et al. Target Volume Delineation and Treatment Planning for Particle Therapy. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42478-1_14
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