Skip to main content
SpringerLink
Log in

OTSC System in All Possible Applications

  • Chapter
  • First Online:
Diagnosis and Endoscopic Management of Digestive Diseases

  • 763 Accesses

Abstract

The development of endoscopic closure devices such as over-the-scope-clips (OTSCs) has made endoscopic management of gastrointestinal fistulas or gastrointestinal bleedings feasible. These nonsurgical approaches have a lower complication rate, shorten the hospital stay and facilitate the prompt resumption of an oral diet [Voermans, R et al Novel overthe-scope-clip system for gastrotomy closure in natural orifice transluminal endoscopic surgery (NOTES): an ex vivo comparison study. Endoscopy 41: 1052-1055, 2009]. Several endoscopic methods to close Fistulas, leakages or bleeding lesions have been described Although hemostatic endoclips have been used for management of perforations and fistulae, their efficacy has been limited by the inability to trap and hold adequate tissue. OTSC has shown its encouraging results in management of various clinical situations also critical (Mori H, et al Rectal perforations and fistulae secondary to a glycerin enema: closure by over-the scope- clip. World J Gastroenterol 18: 3177-3180 2012, Iacopini F, et al, A. Over-the-scope clip closure of two chronic fistulas after gastric band penetration. World J Gastroenterol; 16: 1665-1669, 2010).

In this chapter we present all the possible applications of the OTSC Devices including removal system and the Full-Thickness Resection Applicator.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mori H, Kobara H, Fujihara S, Nishiyama N, Kobayashi M, Masaki T, Izuishi K, Suzuki Y. Rectal perforations and fistulae secondary to a glycerin enema: closure by over-the scope- clip. World J Gastroenterol. 2012;18:3177–80.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Iacopini F, Di Lorenzo N, Altorio F, Schurr MO, Scozzarro A. Over-the-scope clip closure of two chronic fistulas after gastric band penetration. World J Gastroenterol. 2010;16:1665–9.

    Article  PubMed  PubMed Central  Google Scholar 

  3. van Leerdam ME. Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol. 2008;22:209–24.

    Article  PubMed  Google Scholar 

  4. Hearnshaw SA, Logan RF, Lowe D, et al. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011;60:1327–35.

    Article  PubMed  Google Scholar 

  5. Laine L, Yang H, Chang SC, Datto C. Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009. Am J Gastroenterol. 2012;107(8):1190–5.

    Article  PubMed  Google Scholar 

  6. Strate LL, Ayanian JZ, Kotler G, Syngal S. Risk factors for mortality in lower intestinal bleeding. Clin Gastroenterol Hepatol. 2008;6(9):1004–10.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nagata N, Niikura R, Aoki T, Shimbo T, Itoh T, Goda Y, Suda R, Yano H, Akiyama J, Yanase M, Mizokami M, Uemura N. Increase in colonic diverticulosis and diverticular hemorrhage in an aging society: lessons from a 9-year colonoscopic study of 28, 192 patients in Japan. Int J Colorectal Dis. 2014;29(3):379–85.

    Article  PubMed  Google Scholar 

  8. Aoki T, Nagata N, Niikura R, Shimbo T, Tanaka S, Sekine K, Kishida Y, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Recurrence and mortality among patients hospitalized for acute lower gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2015;13(3):488–94.

    Article  PubMed  Google Scholar 

  9. Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol. 1997;92(3):419–24.

    CAS  PubMed  Google Scholar 

  10. Farrell JJ, Friedman LS. Gastrointestinal bleeding in the elderly. Gastroenterol Clin North Am. 2001;30(2):377–407.

    Article  CAS  PubMed  Google Scholar 

  11. Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2005;21(11):1281–98.

    Article  CAS  PubMed  Google Scholar 

  12. Gayer C, Chino A, Lucas C, Tokioka S, Yamasaki T, Edelman DA, Sugawa C. Acute lower gastrointestinal bleeding in 1,112 patients admitted to an urban emergency medical center. Surgery. 2009;146(4):600–6.

    Article  PubMed  Google Scholar 

  13. Ghassemi KA, Jensen DM. Lower GI bleeding: epidemiology and management. Curr Gastroenterol Rep. 2013;15(7):333–5.

    Article  PubMed  Google Scholar 

  14. Hreinsson JP, Gumundsson S, Kalaitzakis E, Bjornsson ES. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur J Gastroenterol Hepatol. 2013;25(1):37–43.

    Article  PubMed  Google Scholar 

  15. Cappell MS, Friedel D. Initial management of acute upper gastrointestinal bleeding: from initial evaluation up to gastrointestinal endoscopy. Med Clin North Am. 2008;92:491–509.

    Article  PubMed  Google Scholar 

  16. Kovacs TO. Management of upper gastrointestinal bleeding. Curr Gastroenterol Rep. 2008;10:535–42.

    Article  PubMed  Google Scholar 

  17. Barkun AN, Martel M, Toubouti Y, et al. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of metaanalyses. Gastrointest Endosc. 2009;69:786–99.

    Article  PubMed  Google Scholar 

  18. Marmo R, Rotondano G, Piscopo R, et al. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007;102:279–89.

    Article  PubMed  Google Scholar 

  19. Barkun AN, Bardou M, Kuipers EJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152:101–13.

    Article  PubMed  Google Scholar 

  20. Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107:345–60.

    Article  CAS  PubMed  Google Scholar 

  21. Sung JJ, Chan FK, Chen M, et al. Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding. Gut. 2011;60:1170–7.

    Article  PubMed  Google Scholar 

  22. Jairath V, Barkun AN. Improving outcomes from acute upper gastrointestinal bleeding. Gut. 2012;61(9):1246–9.

    Article  PubMed  Google Scholar 

  23. Rockall TA, Logan RF, Devlin HB, et al. Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage. BMJ. 1995;311:222–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Chung IK, Ham JS, Kim HS, et al. Comparison of the hemostatic efficacy of the endoscopic hemoclip method with hypertonic saline epinephrine injection and a combination of the two for the management of bleeding peptic ulcers. Gastrointest Endosc. 1999;49:13–8.

    Article  CAS  PubMed  Google Scholar 

  25. Barkun A, Bardou M, Marshall JK, et al. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003;139:843–57.

    Article  PubMed  Google Scholar 

  26. Greenspoon J, Barkun A, Bardou M, et al. Management of patients with nonvariceal upper gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2012;10:234–9.

    Article  PubMed  Google Scholar 

  27. Peng YC, Chen SY, Tung CF, et al. Factors associated with failure of initial endoscopic hemoclip hemostasis for upper gastrointestinal bleeding. J Clin Gastroenterol. 2006;40:25–8.

    Article  PubMed  Google Scholar 

  28. Kirschniak A, Subotova N, Zieker D, et al. The Over-The-Scope Clip (OTSC) for the treatment of gastrointestinal bleeding, perforations, and fistulas. Surg Endosc. 2011;25:2901–5. PubMed PMID: 21424197.

    Article  PubMed  Google Scholar 

  29. Manta R, Galloro G, Mangiavillano B, et al. Over-the-scope clip (OTSC) represents an effective endoscopic treatment for acute GI bleeding after failure of conventional techniques. Surg Endosc. 2013;27:3162–4.

    Article  PubMed  Google Scholar 

  30. Skinner M, Gutierrez JP, Neumann H, Wilcox CM, Burski C, Mönkemüller K. Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. Endosc Int Open. 2014;2(1):E37–40.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Chan SM, Chiu PW, Teoh AY, et al. Use of the over-the scope clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy. 2014;46(5):428–31.

    Article  PubMed  Google Scholar 

  32. Mönkemüller K, Toshniwal J, Zabielski M, Vormbrock K, Neumann H. Utility of the “bear claw”, or over-the-scope clip (OTSC) system, to provide endoscopic hemostatis for bleeding posterior duodenal ulcers. Endoscopy. 2012;44(Suppl 2 UCTN):E412–3.

    PubMed  Google Scholar 

  33. Sung JY, Chung SC, Lo KK, et al. Heater-probe treatment of bleeding peptic ulcers. Surg Endosc. 1988;2:234–6.

    Article  CAS  PubMed  Google Scholar 

  34. Manno M, Mangiafico S, Caruso A, Barbera C, Bertani H, Mirante VG, Pigò F, Amardeep K, Conigliaro R. First-line endoscopic treatment with OTSC in patients with high-risk non-variceal upper gastrointestinal bleeding: preliminary experience in 40 cases. Surg Endosc. 2016;30:2026–9.

    Article  PubMed  Google Scholar 

  35. Neumann H, Diebel H, Mönkemüller K, et al. Description of a new, endoscopic technique to remove the over-the-scope-clip in an ex vivo porcine model (with video). Gastrointest Endosc. 2012;76:1009–13.

    Article  PubMed  Google Scholar 

  36. Mönkemüller K, Toshniwal J, Zabielski M. Endoscopic removal of an over-the-scope-clip (‘bear claw’). Gastrointest Endosc. 2012;76:1077–8.

    Article  PubMed  Google Scholar 

  37. Schostek S, Ho CN, Melbert M, Krautwald M, Caputo A, Parisi G, Wehrmann M, Gottwald T, Schurr MO. DC current pulses for OTSC clip fragmentation: technology and experimental study. Surg Endosc. 2015;29(8):2418–22.

    Article  PubMed  Google Scholar 

  38. Arezzo A, Bullano A, Fisher H, Morino M. The way to remove an over-the-scope-clip (with video). Gastrointest Endosc. 2013;77:974–5.

    Article  PubMed  Google Scholar 

  39. Schmidt A, Riechen B, Damm M, Cahyadi O, Bauder M, Caca K. Endoscopic removal of over-the-scope clips using a novel cutting device : a retrospective case series. Endoscopy. 2014;46:762–6.

    Article  PubMed  Google Scholar 

  40. Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87. PubMed PMID: 22885331.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Caulfield H, Hyman NH. Anastomotic leak after low anterior resection: a spectrum of clinical entities. JAMA Surg. 2013;148(2):177–82.

    Article  PubMed  Google Scholar 

  42. Metcalf C. Enterocutaneous fistulae. J Wound Care. 1999;8(3):141–2. Review.

    Article  CAS  PubMed  Google Scholar 

  43. Lüning TH, Keemers-Gels ME, Barendregt WB, et al. Colonoscopic perforations: a review of 30,366 patients. Surg Endosc. 2007;21(6):994–7.

    Article  PubMed  Google Scholar 

  44. Svanes C. Trends in perforated peptic ulcer: incidence, etiology, treatment, and prognosis. World J Surg. 2000;24(3):277–83. Review.

    Article  CAS  PubMed  Google Scholar 

  45. Iqbal CW, Cullinane DC, Schiller HJ, et al. Surgical management and outcomes of 165 colonoscopic perforations from a single institution. Arch Surg. 2008;143(7):701–6.

    Article  PubMed  Google Scholar 

  46. van der Sluis FJ, Loffeld RJ, Engel AF. Outcome of surgery for colonoscopic perforation. Colorectal Dis. 2012;14(4):e187–90.

    Article  PubMed  Google Scholar 

  47. Rodella L, Laterza E, De Manszoni G, et al. Endoscopic clipping of anastomotic leakages in esophagogastric surgery. Endoscopy. 1998;30(5):453–6.

    Article  CAS  PubMed  Google Scholar 

  48. Will U, Meyer F, Hartmeier S, et al. Endoscopic treatment of a pseudocystocolonic fistula by band ligation and endoloop application: case report. Gastrointest Endosc. 2004;59(4):581–3.

    Article  PubMed  Google Scholar 

  49. Bohm G, Mossdorf A, Klink C, et al. Treatment algorithm for post-operative upper gastrointestinal fistulas and leaks using combined Vicrylplug and fibrin glue. Endoscopy. 2010;42(7):599–602. PubMed PMID: 20432210.

    Article  CAS  PubMed  Google Scholar 

  50. Disibeyaz S, Parlak E, Köksal A, et al. Endoscopic treatment of a large upper gastrointestinal anastomotic leak using a prolene plug and cyanoacrylate. Endoscopy. 2005;37(10):1032–3.

    Article  CAS  PubMed  Google Scholar 

  51. van Boeckel PG, Dua KS, Weusten BL, et al. Fully covered self-expandable metal stents (SEMS), partially covered SEMS and selfexpandable plastic stents for the treatment of benign esophageal ruptures and anastomotic leaks. BMC Gastroenterol. 2012;29(2):12:19.

    Google Scholar 

  52. Trecca A, Gaj F, Gagliardi G. Our experience with endoscopic repair of large colonoscopic perforations and review of the literature. Tech Coloproctol. 2008;12(4):315–21.

    Article  CAS  PubMed  Google Scholar 

  53. Cheriyan D, Enns R. Over-the-scope clip in the management of GI defects. Gastrointest Endosc. 2014;80(4):623–5.

    Article  PubMed  Google Scholar 

  54. Baron TH, Song LM, Ross A, et al. Use of an over-the-scope clipping device: multicenter retrospective results of the first U.S. experience (with videos). Gastrointest Endosc. 2012;76(1):202–8.

    Article  PubMed  Google Scholar 

  55. Mangiavillano B, Morandi E, Masci E. Accidental endoscopic piercing of the tongue with an Ovesco clip. Endoscopy. 2012;44(S 02):E221.

    Article  PubMed  Google Scholar 

  56. Voermans RP, Le Moine O, von Renteln D, et al. Efficacy of endoscopic closure of acute perforations of the gastrointestinal tract. Clin Gastroenterol Hepatol. 2012;10(6):603–8.

    Article  PubMed  Google Scholar 

  57. Alastal Y, Hammad TA, Nawras M, et al. Acute cholangitis following biliary obstruction after duodenal OTSC placement in a case of large chronic duodenocutaneous fistula. Case Rep Gastrointest Med. 2015;2015:647806.

    PubMed  PubMed Central  Google Scholar 

  58. Kim M, Jeon SW, Cho KB, et al. Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study. Surg Endosc. 2013;27(4):1372–8.

    Article  PubMed  Google Scholar 

  59. Samalavicius NE, Kazanavicius D, Lunevicius R, et al. Incidence, risk, management, and outcomes of iatrogenic full-thickness large bowel injury associated with 56,882 colonoscopies in 14 Lithuanian hospitals. Surg Endosc. 2013;27(8):1628–35.

    Article  PubMed  Google Scholar 

  60. Technology Committee ASGE, Kantsevoy SV, Adler DG, Conway JD, et al. Endoscopic mucosal resection and endoscopic submucosal dissection. Gastrointest Endosc. 2008;68(1):11–8. Review.

    Article  Google Scholar 

  61. Kirschniak A, Kratt T, Stüker D, et al. A new endoscopic over-the-scope clip system for treatment of lesions and bleeding in the GI tract: first clinical experiences. Gastrointest Endosc. 2007;66(1):162–7.

    Article  PubMed  Google Scholar 

  62. Repici A, Arezzo A, De Caro G, et al. Clinical experience with a new endoscopic over-the-scope clip system for use in the GI tract. Dig Liver Dis. 2009;41(6):406–10.

    Article  CAS  PubMed  Google Scholar 

  63. Seebach L, Bauerfeind P, Gubler C. “Sparing the surgeon”: clinical experience with over-the-scope clips for gastrointestinal perforation. Endoscopy. 2010;42(12):1108–11. PubMed PMID: 21120779.

    Article  CAS  PubMed  Google Scholar 

  64. Sandmann M, Heike M, Faehndrich M. Application of the OTSC system for the closure of fistulas, anastomosal leakages and perforations within the gastrointestinal tract. Z Gastroenterol. 2011;49(8):981–5.

    Article  CAS  PubMed  Google Scholar 

  65. Gubler C, Bauerfeind P. Endoscopic closure of iatrogenic gastrointestinal tract perforations with the over-the-scope clip. Digestion. 2012;85(4):302–7.

    Article  PubMed  Google Scholar 

  66. Hagel AF, Naegel A, Lindner AS, et al. Over-the-scope clip application yields a high rate of closure in gastrointestinal perforations and may reduce emergency surgery. J Gastrointest Surg. 2012;16(11):2132–8.

    Article  PubMed  Google Scholar 

  67. Nishiyama N, Mori H, Kobara H, et al. Efficacy and safety of over-the- scope clip: including complications after endoscopic submucosal dissection. World J Gastroenterol. 2013;19(18):2752–60.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Schlag C, Wilhelm D, von Delius S, et al. EndoResect study: endoscopic full-thickness resection of gastric subepithelial tumors. Endoscopy. 2013;45(1):4–11.

    CAS  PubMed  Google Scholar 

  69. Changela K, Virk MA, Patel N, et al. Role of over the scope clips in the management of iatrogenic gastrointestinal perforations. World J Gastroenterol. 2014;20(32):11460–2.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Haito-Chavez Y, Law JK, Kratt T, et al. International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video). Gastrointest Endosc. 2014;80(4):610–22.

    Article  PubMed  Google Scholar 

  71. Farnik H, Driller M, Kratt T, et al. Indication for ‘Over the scope’ (OTS)-clip vs. covered self-expanding metal stent (cSEMS) is unequal in upper gastrointestinal leakage: results from a retrospective head-to-head comparison. PLoS One. 2015;10(1):e0117483.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Paspatis GA, Dumonceau JM, Barthet M, et al. Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy. 2014;46(8):693–711. Review.

    Article  PubMed  Google Scholar 

  73. Griffith PS, Birch DW, Sharma AM, et al. Managing complications associated with laparoscopic Roux-en-Y gastric bypass for morbid obesity. Can J Surg. 2012;55(5):329–36. Review.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Fullum TM, Aluka KJ, Turner PL. Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2009;23(6):1403–8.

    Article  PubMed  Google Scholar 

  75. Sakuramoto S, Kikuchi S, Futawatari N, et al. Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy. Surg Endosc. 2009;23(11):2416–23.

    Article  PubMed  Google Scholar 

  76. Kim SG, Lee YJ, Ha WS, et al. LATG with extracorporeal esophagojejunostomy: is this minimal invasive surgery for gastric cancer? J Laparoendosc Adv Surg Tech A. 2008;18(4):572–8.

    Article  PubMed  Google Scholar 

  77. Kim MG, Kim BS, Kim TH, et al. The effects of laparoscopic assisted total gastrectomy on surgical outcomes in the treatment of gastric cancer. J Korean Surg Soc. 2011;80(4):245–50.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Smith JD, Paty PB, Guillem JG, et al. Anastomotic leak is not associated with oncologic outcome in patients undergoing low anterior resection for rectal cancer. Ann Surg. 2012;256(6):1034–8.

    Article  PubMed  Google Scholar 

  79. Mirnezami A, Mirnezami R, Chandrakumaran K, et al. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg. 2011;253(5):890–9.

    Article  PubMed  Google Scholar 

  80. Schecter WP, Hirshberg A, Chang DS, et al. Enteric fistulas: principles of management. J Am Coll Surg. 2009;209(4):484–91. Review.

    Article  PubMed  Google Scholar 

  81. Parodi A, Repici A, Pedroni A, et al. Endoscopic management of GI perforations with a new over-the-scope clip device (with videos). Gastrointest Endosc. 2010;72(4):881–6.

    Article  PubMed  Google Scholar 

  82. Pohl J, Borgulya M, Lorenz D, et al. Endoscopic closure of postoperative esophageal leaks with a novel over-the-scope clip system. Endoscopy. 2010;42(9):757–9.

    Article  CAS  PubMed  Google Scholar 

  83. Albert JG, Friedrich-Rust M, Woeste G, et al. Benefit of a clipping device in use in intestinal bleeding and intestinal leakage. Gastrointest Endosc. 2011;74(2):389–97.

    Article  PubMed  Google Scholar 

  84. Manta R, Manno M, Bertani H, et al. Endoscopic treatment of gastrointestinal fistulas using an over-the-scope clip (OTSC) device: case series from a tertiary referral center. Endoscopy. 2011;43(6):545–8.

    Article  CAS  PubMed  Google Scholar 

  85. Surace M, Mercky P, Demarquay JF, et al. Endoscopic management of GI fistulae with the over-the-scope clip system (with video). Gastrointest Endosc. 2011;74(6):1416–9.

    Article  PubMed  Google Scholar 

  86. Arezzo A, Verra M, Reddavid R, et al. Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal postsurgical leaks and fistulas. Surg Endosc. 2012;26(11):3330–3.

    Article  PubMed  Google Scholar 

  87. Dişibeyaz S, Köksal AŞ, Parlak E, et al. Endoscopic closure of gastrointestinal defects with an over-the-scope clip device. A case series and review of the literature. Clin Res Hepatol Gastroenterol. 2012;36(6):614–21. Review.

    Article  PubMed  Google Scholar 

  88. Galizia G, Napolitano V, Castellano P, et al. The Over-The-Scope-Clip (OTSC) system is effective in the treatment of chronic esophagojejunal anastomotic leakage. J Gastrointest Surg. 2012;16(8):1585–9.

    Article  PubMed  Google Scholar 

  89. Mennigen R, Colombo-Benkmann M, Senninger N, et al. Endoscopic closure of postoperative gastrointestinal leakages and fistulas with the Over-the-Scope Clip (OTSC). J Gastrointest Surg. 2013;17(6):1058–65.

    Article  PubMed  Google Scholar 

  90. Winder JS, Kulaylat AN, Schubart JR, et al. Management of non-acute gastrointestinal defects using the over-the-scope clips (OTSCs): a retrospective single-institution experience. Surg Endosc. 2015;28. [Epub ahead of print].

    Google Scholar 

  91. Law R, Wong Kee Song LM, Irani S, et al. Immediate technical and delayed clinical outcome of fistula closure using an over-the-scope clip device. Surg Endosc. 2015;29(7):1781–6.

    Article  PubMed  Google Scholar 

  92. Weiland T, Fehlker M, Gottwald T, et al. Performance of the OTSC System in the endoscopic closure of gastrointestinal fistulae--a meta-analysis. Minim Invasive Ther Allied Technol. 2012;21(4):249–58.

    Article  PubMed  Google Scholar 

  93. Mangiavillano B, Pisani A, Viaggi P, et al. Endoscopic sealing of a rectovesical fistula with a combination of an over the scope clip and cyano-acrylate injection. J Gastrointest Oncol. 2010;1(2):122–4. PubMed PMID: 22811817.

    PubMed  PubMed Central  Google Scholar 

  94. Schurr MO, Baur FE, Krautwald M, Fehlker M, Wehrmann M, Gottwald T, Prosst RL. Endoscopic full-thickness resection and clip defect closure in the colon with the new FTRD system: experimental study. Surg Endosc. 2015;29:2434–41. PMID: 25318369. doi:10.1007/s00464-014-3923-x.

  95. Schurr MO, Baur F, Ho CN, Anhoeck G, Kratt T, Gottwald T. Endoluminal full-thickness resection of GI lesions: a new device and technique. Minim Invasive Ther Allied Technol. 2011;20:189–92. PMID: 21574825. doi:10.3109/13645706.2011.582119.

  96. von Renteln D, Kratt T, Rösch T, Denzer UW, Schachschal G. Endoscopic full-thickness resection in the colon by using a clipand-cut technique: an animal study. Gastrointest Endosc. 2011;74:1108–14. PMID: 21944313. doi:10.1016/j.gie.2011.07.003.

  97. von Renteln D, Rösch T, Kratt T, Denzer UW, El-Masry M, Schachschal G. Endoscopic full-thickness resection of submucosal gastric tumors. Dig Dis Sci. 2012;57:1298–303. PMID: 22370915. doi:10.1007/s10620-012-2039-1.

  98. Schmidt A, Damm M, Caca K. Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology. 2014;147:740–2.e2. PMID: 25083605. doi:10.1053/j.gastro.2014.07.045.

  99. Valli PV, Kaufmann M, Vrugt B, Bauerfeind P. Endoscopic resection of a diverticulum-arisen colonic adenoma using a fullthickness resection device. Gastroenterology. 2014;147:969–71.

    Article  PubMed  Google Scholar 

  100. Schmidt A, Bauerfeind P, Gubler C, Damm M, Bauder M, Caca K. Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience. Endoscopy. 2015;47:719–25. doi:10.1055/s-0034-1391781. Epub 2015 Mar 12.

    Article  PubMed  Google Scholar 

  101. Lagoussis P, Soriani P, Tontini GE, Neumann H, Pastorelli L, de Nucci G, Vecchi M. Over-the-scope clip-assisted endoscopic full-thickness resection after incomplete resection of rectal adenocarcinoma. Endoscopy. 2016;48 Suppl 1:E59–60. doi:10.1055/s-0042-100197. Epub 2016 Feb 18.

    PubMed  Google Scholar 

  102. Klare P, Burlefinger R, Neu B, Bajbouj M, Specht K, Schmid RM, von Delius S. Over-the-scope clip-assisted endoscopic full-thickness resection after incomplete resection of a rectal neuroendocrine tumor. Endoscopy. 2015;47(Suppl 1 UCTN):E47–8. doi: 10.1055/s-0034-1391301. Epub 2015 Feb.

  103. Saito Y, Uraoka T, Yamaguchi Y, et al. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc. 2010;72:1217–25.

    Article  PubMed  Google Scholar 

  104. Schmidt A, Meier B, Caca K. Endoscopic full-thickness resection: current status. World J Gastroenterol. 2015;21:9273–85.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Digestive Endoscopy Unit, Baggiovara Hospital, Modena, Italy

    Rita Conigliaro MD & Santi Mangiafico

  2. Digestive Endoscopy Unit, San Paolo Hospital, Milano, Italy

    Giuseppe Iabichino, Monica Arena & Carmelo Luigiano

Authors
  1. Rita Conigliaro MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Santi Mangiafico
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Iabichino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Monica Arena
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carmelo Luigiano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rita Conigliaro MD .

Editor information

Editors and Affiliations

  1. S. Agostino Estense Hospital, Modena, Italy

    Rita Conigliaro

  2. S. Agostino Estense Hospital, Modena, Italy

    Marzio Frazzoni

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Conigliaro, R., Mangiafico, S., Iabichino, G., Arena, M., Luigiano, C. (2017). OTSC System in All Possible Applications. In: Conigliaro, R., Frazzoni, M. (eds) Diagnosis and Endoscopic Management of Digestive Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-42358-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42358-6_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42356-2

  • Online ISBN: 978-3-319-42358-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation