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Circulating Tumor Cells (CTCs) and Metastatic Prostate Cancer (mPCa)

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Bone Metastases from Prostate Cancer

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Abstract

The great advances in mPCa management recently obtained with the second-line treatments have highlighted the need to identify and exploit surrogate endpoints for survival of patients and effectiveness of treatment. These surrogate endpoints could be also used to reduce size and costs of pivotal trials of new molecules and the time from the benchtop to the patients’ bedside. A large consensus is emerging in the scientific community that circulating tumor cells (CTCs) meet the criteria required for a surrogate endpoint, particularly in mPCa.

The main open question about the clinical management of mPCa is discussed, with the intent to underscore how the extended use of CTC detection and characterization can offer further benefit to these patients.

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Authors and Affiliations

  1. Department of Surgery, Oncology and Gastroenterology, Oncology Section, University of Padova, Padova, Italy

    Elisabetta Rossi

  2. Immunology and Molecular Oncology Unit, IOV-IRCCS, Padova, Italy

    Rita Zamarchi

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  1. Elisabetta Rossi
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  2. Rita Zamarchi
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Correspondence to Elisabetta Rossi .

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Editors and Affiliations

  1. University of Verona, Director of Metabolic Bone Diseases and Osteoncology Unit, Internal Medicine Department of Medicine, Verona, Italy

    Francesco Bertoldo

  2. IRCCS AOU San Martino-IST National Cancer Research Institute, Department of Internal Medicine and Medical specialties (DIMI), School of Medical and Pharmacological Sciences, University of Genoa, Academic Unit of Medical Oncology, Department of Oncology (DIPOE), Genoa, Italy

    Francesco Boccardo

  3. Humanitas Gavazzeni Clinic, Clical Scientific Director Department of Nuclear Medicine, Bergamo, Italy

    Emilio Bombardieri

  4. Veneto Institute of Oncology IOV - IRCCS, Nuclear Medicine and Molecular imaging Unit, Padova, Italy

    Laura Evangelista

  5. Radiation Oncology 1 and Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Oncology and Hemato-oncology, Università di Milano, Milan, Italy

    Riccardo Valdagni

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Rossi, E., Zamarchi, R. (2017). Circulating Tumor Cells (CTCs) and Metastatic Prostate Cancer (mPCa). In: Bertoldo, F., Boccardo, F., Bombardieri, E., Evangelista, L., Valdagni, R. (eds) Bone Metastases from Prostate Cancer . Springer, Cham. https://doi.org/10.1007/978-3-319-42327-2_5

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