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Chemotherapy

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Bone Metastases from Prostate Cancer

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Abstract

Nearly all patients with metastatic prostate cancer (PC) become resistant to the initial approach with androgen deprivation therapy (ADT), developing the state known as metastatic castration-resistant prostate cancer (mCRPC). For nearly a decade, chemotherapy with docetaxel has been the only established standard of care in this setting. In recent years, treatment of mCRPC has changed dramatically due to the improvement in the understanding of CRPC biology, which has revealed that during the progression to the castrate status, PC cells remain dependent on androgens and on the androgen receptor (AR) signaling pathway. Multiple novel agents that have demonstrated to improve OS, symptom control, and QoL in mCRPC have been approved, including sipuleucel-T, cabazitaxel, abiraterone acetate, enzalutamide, and radium-223. The optimal sequencing and combination of these treatments still need to be defined. However, chemotherapy with docetaxel and cabazitaxel remains an important therapeutic option for patients with mCRPC, with potential clinical effect on bone metastases.

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Authors and Affiliations

  1. Department of Medical Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy

    Giovanni Luca Ceresoli, Maria Bonomi & Maria Grazia Sauta

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  1. Giovanni Luca Ceresoli
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  2. Maria Bonomi
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  3. Maria Grazia Sauta
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Correspondence to Giovanni Luca Ceresoli .

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Editors and Affiliations

  1. University of Verona, Director of Metabolic Bone Diseases and Osteoncology Unit, Internal Medicine Department of Medicine, Verona, Italy

    Francesco Bertoldo

  2. IRCCS AOU San Martino-IST National Cancer Research Institute, Department of Internal Medicine and Medical specialties (DIMI), School of Medical and Pharmacological Sciences, University of Genoa, Academic Unit of Medical Oncology, Department of Oncology (DIPOE), Genoa, Italy

    Francesco Boccardo

  3. Humanitas Gavazzeni Clinic, Clical Scientific Director Department of Nuclear Medicine, Bergamo, Italy

    Emilio Bombardieri

  4. Veneto Institute of Oncology IOV - IRCCS, Nuclear Medicine and Molecular imaging Unit, Padova, Italy

    Laura Evangelista

  5. Radiation Oncology 1 and Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Oncology and Hemato-oncology, Università di Milano, Milan, Italy

    Riccardo Valdagni

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Ceresoli, G.L., Bonomi, M., Sauta, M.G. (2017). Chemotherapy. In: Bertoldo, F., Boccardo, F., Bombardieri, E., Evangelista, L., Valdagni, R. (eds) Bone Metastases from Prostate Cancer . Springer, Cham. https://doi.org/10.1007/978-3-319-42327-2_11

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