Abstract
Hybrid imaging is an emerging technology that typically fuses a combination of high-sensitivity, nuclear imaging techniques, such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT), with high-resolution, anatomical imaging using computed tomography (CT) or magnetic resonance imaging (MRI). CT was the first partner in hybrid imaging systems and modern interest has focused on development of MRI hybrids. To fully exploit the benefits of hybrid imaging technology, researchers have been investigating the use of radiolabeled and paramagnetic, nanoparticle-based probes to allow simultaneous imaging with PET/SPECT and MRI for a variety of applications including targeted tumor imaging, stem cell tracking, and monitoring of response to therapy. This chapter provides an overview of unique designs for nanoparticle-based SPECT/MRI and PET/MRI probes, and their imaging applications, reported in the period of 2010–2015.
Keywords
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lee S, Chen X. Dual-modality probes for in vivo molecular imaging. Mol Imaging. 2009;8(2):87.
Rahmim A, Zaidi H. PET versus SPECT: strengths, limitations and challenges. Nucl Med Commun. 2008;29(3):193–207.
Cherry SR, editor. Multimodality imaging: beyond pet/ct and spect/ct. Seminars in nuclear medicine. Elsevier; 2009.
Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med. 2000;41(8):1369–79.
Cherry SR, Louie AY, Jacobs RE. The integration of positron emission tomography with magnetic resonance imaging. Proc IEEE. 2008;96(3):416–38.
Garcia J, Tang T, Louie AY. Nanoparticle-based multimodal PET/MRI probes. Nanomedicine. 2015;10(8):1343–59.
Puttick S, Bell C, Dowson N, Rose S, Fay M. PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma. Drug Discov Today. 2015;20(3):306–17.
Rosales R. Potential clinical applications of bimodal PET‐MRI or SPECT‐MRI agents. J Label Compd Radiopharm. 2014;57(4):298–303.
Bouziotis P, Psimadas D, Tsotakos T, Stamopoulos D, Tsoukalas C. Radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI agents. Curr Top Med Chem. 2012;12(23):2694–702.
Singh N, Jenkins GJ, Asadi R, Doak SH. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev. 2010;1.
Wang Y-XJ. Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application. Quant Imaging Med Surg. 2011;1(1):35.
Tsiapa I, Efthimiadou EK, Fragogeorgi E, Loudos G, Varvarigou AD, Bouziotis P, et al. 99mTc-labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of ανβ3-mediated tumor expression and feasibility for hyperthermia treatment. J Colloid Interface Sci. 2014;433:163–75.
Cui X, Mathe D, Kovács N, Horvath I, Jauregui-Osoro M, Torres Martin de Rosales R, et al. Synthesis, characterization and application of core-shell Co0.16Fe2.84O4@NaYF4 (Yb, Er) and Fe3O4@NaYF4 (Yb, Tm) nanoparticle as tri-modal (MRI, PET/SPECT and optical) imaging agents. Bioconjug Chem. 2015.
Xue S, Zhang C, Yang Y, Zhang L, Cheng D, Zhang J, et al. 99mTc-labeled iron oxide nanoparticles for dual-contrast (T 1/T 2) magnetic resonance and dual-modality imaging of tumor angiogenesis. J Biomed Nanotechnol. 2015;11(6):1027–37.
Cheng D, Li X, Zhang C, Tan H, Wang C, Pang L, et al. Detection of vulnerable atherosclerosis plaques with a dual-modal single-photon-emission computed tomography/magnetic resonance imaging probe targeting apoptotic macrophages. ACS Appl Mater Interfaces. 2015;7(4):2847–55.
Liu S, Jia B, Qiao R, Yang Z, Yu Z, Liu Z, et al. A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application. Mol Pharm. 2009;6(4):1074–82.
Lee CM, Jeong HJ, Kim EM, Kim DW, Lim ST, Kim HT, et al. Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo. Magn Reson Med. 2009;62(6):1440–6.
Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, et al. Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles. Int J Nanomedicine. 2013;8:4659.
de Vries A, Kok MB, Sanders HM, Nicolay K, Strijkers GJ, Grüll H. Multimodal liposomes for SPECT/MR imaging as a tool for in situ relaxivity measurements. Contrast Media Mol Imaging. 2012;7(1):68–75.
Truillet C, Bouziotis P, Tsoukalas C, Brugière J, Martini M, Sancey L et al. Ultrasmall particles for Gd‐MRI and 68Ga‐PET dual imaging. Contrast Media Mol Imaging. 2014.
Luo J, Wilson JD, Zhang J, Hirsch JI, Dorn HC, Fatouros PP, et al. A dual PET/MR imaging nanoprobe: 124I labeled Gd3N@ C80. Appl Sci. 2012;2(2):465–78.
Laprise-Pelletier M, Bouchoucha M, Lagueux J, Chevallier P, Lecomte R, Gossuin Y, et al. Metal chelate grafting at the surface of mesoporous silica nanoparticles (MSNs): physico-chemical and biomedical imaging assessment. J Mater Chem B. 2015;3(5):748–58.
Madru R, Kjellman P, Olsson F, Wingårdh K, Ingvar C, Ståhlberg F, et al. 99mTc-labeled superparamagnetic iron oxide nanoparticles for multimodality SPECT/MRI of sentinel lymph nodes. J Nucl Med. 2012;53(3):459–63.
de Rosales RTM, Tavaré R, Glaria A, Varma G, Protti A, Blower PJ. 99mTc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug Chem. 2011;22:455–65.
Felber M, Alberto R. 99mTc radiolabelling of Fe3O4–Au core–shell and Au–Fe3O4 dumbbell-like nanoparticles. Nanoscale. 2015;7(15):6653–60.
Zhao Y, Yao Q, Tan H, Wu B, Hu P, Wu P, et al. Design and preliminary assessment of 99mTc-labeled ultrasmall superparamagnetic iron oxide-conjugated bevacizumab for single photon emission computed tomography/magnetic resonance imaging of hepatocellular carcinoma. J Radioanal Nucl Chem. 2014;299(3):1273–80.
Madru R, Svenmarker P, Ingvar C, Ståhlberg F, Engels S-A, Knutsson L, et al. Development of a hybrid nanoprobe for triple-modality MR/SPECT/optical fluorescence imaging. Diagnostics. 2014;4(1):13–26.
Psimadas D, Baldi G, Ravagli C, Bouziotis P, Xanthopoulos S, Franchini MC, et al. Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core: in vivo biodistribution. J Biomed Nanotechnol. 2012;8(4):575–85.
Tang Y, Zhang C, Wang J, Lin X, Zhang L, Yang Y, et al. MRI/SPECT/fluorescent tri-modal probe for evaluating the homing and therapeutic efficacy of transplanted mesenchymal stem cells in a rat ischemic stroke model. Adv Funct Mater. 2015;25(7):1024–34.
Deng S, Zhang W, Zhang B, Hong R, Chen Q, Dong J, et al. Radiolabeled cyclic arginine-glycine-aspartic (RGD)-conjugated iron oxide nanoparticles as single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) dual-modality agents for imaging of breast cancer. J Nanopart Res. 2015;17(1):1–11.
Chen J, Zhu S, Tong L, Li J, Chen F, Han Y, et al. Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice. BMC Cancer. 2014;14(1):114.
Misri R, Meier D, Yung AC, Kozlowski P, Häfeli UO. Development and evaluation of a dual-modality (MRI/SPECT) molecular imaging bioprobe. Nanomedicine. 2012;8(6):1007–16.
Zeng J, Jia B, Qiao R, Wang C, Jing L, Wang F, et al. In situ 111 in-doping for achieving biocompatible and non-leachable 111In-labeled Fe3O4 nanoparticles. Chem Commun. 2014;50(17):2170–2.
Hoffman D, Sun M, Yang L, McDonagh PR, Corwin F, Sundaresan G, et al. Intrinsically radiolabelled [59Fe]-SPIONs for dual MRI/radionuclide detection. Am J Nucl Med Mol Imaging. 2014;4(6):548.
Rasaneh S, Rajabi H, Daha FJ. Activity estimation in radioimmunotherapy using magnetic nanoparticles. Chin J Cancer Res. 2015;27(2):203.
Chakravarty R, Valdovinos HF, Chen F, Lewis CM, Ellison PA, Luo H, et al. Intrinsically germanium‐69‐labeled iron oxide nanoparticles: synthesis and in‐vivo dual‐modality PET/MR imaging. Adv Mater. 2014;26(30):5119–23.
Cho B-B, Park JH, Jung SJ, Lee J, Lee JH, Hur MG et al. Synthesis and characterization of 68Ga labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI). J Radioanal Nucl Chem. 2015:1–10.
Tu C, Ng TS, Jacobs RE, Louie AY. Multimodality PET/MRI agents targeted to activated macrophages. J Biol Inorg Chem. 2014;19(2):247–58.
Boros E, Bowen AM, Josephson L, Vasdev N, Holland JP. Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles. Chem Sci. 2015;6(1):225–36.
Bhattacharya S. Radiation injury. Indian J Plastic Surg. 2010;43(Suppl):S91.
Zhu J, Zhang B, Tian J, Wang J, Chong Y, Wang X, et al. Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging. Nanoscale. 2015;7(8):3392–5.
Wong RM, Gilbert DA, Liu K, Louie AY. Rapid size-controlled synthesis of dextran-coated, 64Cu-doped iron oxide nanoparticles. ACS Nano. 2012;6(4):3461–7.
Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H, et al. Affibody modified and radiolabeled gold–iron oxide hetero-nanostructures for tumor PET, optical and MR imaging. Biomaterials. 2013;34(11):2796–806.
Chen F, Ellison PA, Lewis CM, Hong H, Zhang Y, Shi S, et al. Chelator‐free synthesis of a dual‐modality PET/MRI agent. Angew Chem Int Ed. 2013;52(50):13319–23.
Locatelli E, Gil L, Israel LL, Passoni L, Naddaka M, Pucci A, et al. Biocompatible nanocomposite for PET/MRI hybrid imaging. Int J Nanomed. 2012;7:6021.
Tang T, Tu C, Chow SY, Leung KH, Du S, Louie AY. Quantitative assessment of binding affinities for nanoparticles targeted to the vulnerable plaque. Bioconjug Chem. 2015;26(6):1086–94.
Zhou J, Yu M, Sun Y, Zhang X, Zhu X, Wu Z, et al. Fluorine-18-labeled Gd 3+/Yb 3+/Er 3+ co-doped NaYF 4 nanophosphors for multimodality PET/MR/UCL imaging. Biomaterials. 2011;32(4):1148–56.
S-m K, Chae MK, Yim MS, Jeong IH, Cho J, Lee C, et al. Hybrid PET/MR imaging of tumors using an oleanolic acid-conjugated nanoparticle. Biomaterials. 2013;34(33):8114–21.
Yang X, Hong H, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, et al. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials. 2011;32(17):4151–60.
Madru R, Tran TA, Axelsson J, Ingvar C, Bibic A, Ståhlberg F, et al. 68Ga-labeled superparamagnetic iron oxide nanoparticles (SPIONs) for multi-modality PET/MR/Cherenkov luminescence imaging of sentinel lymph nodes. Am J Nucl Med Mol Imaging. 2014;4(1):60.
Cui X, Belo S, Krüger D, Yan Y, de Rosales RT, Jauregui-Osoro M, et al. Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials. 2014;35(22):5840–6.
Thorek DL, Ulmert D, Diop N-FM, Lupu ME, Doran MG, Huang, R et al. Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle. Nat Commun. 2014;5(3097).
Aryal S, Key J, Stigliano C, Landis MD, Lee DY, Decuzzi P. Positron emitting magnetic nanoconstructs for PET/MR imaging. Small. 2014;10(13):2688–96.
Wang H, Kumar R, Nagesha D, Duclos RI, Sridhar S, Gatley SJ. Integrity of 111In-radiolabeled superparamagnetic iron oxide nanoparticles in the mouse. Nucl Med Biol. 2015;42(1):65–70.
Tsai CS, Liu WC, Chen HY, Hsu WC, editors. Preparation and characterization of Fe3O4 Magnetic nanoparticles labeled with Technetium-99m pertectnetate. App Mech Mater. 2014. Trans Tech Publ.
Debinski W, Tatter SB. Convection-enhanced delivery for the treatment of brain tumors. 2009.
Jarrett BR, Correa C, Ma KL, Louie AY. In vivo mapping of vascular inflammation using multimodal imaging. PLoS One. 2010;5(10):e13254.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Tang, T., Garcia, J., Louie, A.Y. (2017). PET/SPECT/MRI Multimodal Nanoparticles. In: Bulte, J., Modo, M. (eds) Design and Applications of Nanoparticles in Biomedical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-42169-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-42169-8_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-42167-4
Online ISBN: 978-3-319-42169-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)