Abstract
The identification of pre-transplant liver disorders is important to avoid post-transplant development of venocclusive disease/sinusoidal obstruction syndrome (VOD/SOS) or hepatic decompensation. The pre-transplant disorders which predispose an increased risk of death are inflammatory conditions like viral hepatitis, fibrosing liver disorders such as cirrhosis or nonalcoholic steatohepatitis (NASH), myeloproliferative disorders, and prior history of liver toxicity after exposure to certain oncology drugs. Recognition of these disorders will affect the eligibility for transplant or may lead to a change in the pre-transplant conditioning regimen. The pathophysiology of VOD/SOS is presented. The clinical and histologic gold standards for diagnosing VOD/SOS are discussed, since occluded venules may be clinically silent.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hogan WJ, Maris M, Storer B, et al. Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients. Blood. 2004;103(1):78–84.
Angelucci E, Muretto P, Lucarelli G, et al. Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation. Italian Cooperative Group for Phlebotomy Treatment of Transplanted Thalassemia Patients. Blood. 1997;90(3):994–8.
Strasser SI, Kowdley KV, Sale GE, McDonald GB. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant. 1998;22(2):167–73.
McDonald GB, Frieze D. A problem-oriented approach to liver disease in oncology patients. Gut. 2008;57(7):987–1003.
DeLeve LD, Valla DC, Garcia-Tsao G. American Association for the Study Liver D. Vascular disorders of the liver. Hepatology. 2009;49(5):1729–64.
Mohty M, Malard F, Abecassis M, et al. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 2015;50(6):781–9.
DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002;22(1):27–42.
Rajvanshi P. Hepatic sinusoidal obstruction after gemtuzumab ozogamicin (Mylotarg) therapy. Blood. 2002;99(7):2310–4.
McDonald GB, Freston JW, Boyer JL, DeLeve LD. Liver complications following treatment of hematologic malignancy with anti-CD22 calicheamicin (Inotuzumab Ozogamicin). Hepatology. 2018. In press.
Shulman HM, Fisher LB, Schoch HG, Henne KW, McDonald GB. Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms. Hepatology. 1994;19(5):1171–81.
Shulman HM, McDonald GB, Matthews D, et al. An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology. 1980;79(6):1178–91.
McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology. 1984;4(1):116–22.
Ma C, Brunt EM. Terminal hepatic venule injury in liver biopsies of allogeneic haematopoietic stem cell recipients-a study of 63 cases. Histopathology. 2016;68(7):996–1003.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Shulman, H.M. (2019). Pre-transplant Liver Disorders: Post-transplant Impact on Developing Venocclusive Disease/Sinusoidal Obstruction Syndrome and Other Hepatic Problems. In: Yeung, C., Shulman, H. (eds) Pathology of Graft vs. Host Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-42099-8_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-42099-8_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-42098-1
Online ISBN: 978-3-319-42099-8
eBook Packages: MedicineMedicine (R0)