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Image Analysis of the Tumor Microenvironment

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Book cover Systems Biology of Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 936))

Abstract

In the field of pathology it is clear that molecular genomics and digital imaging represent two promising future directions, and both are as relevant to the tumor microenvironment as they are to the tumor itself (Beck AH et al. Sci Transl Med 3(108):108ra113–08ra113, 2011). Digital imaging, or whole slide imaging (WSI), of glass histology slides facilitates a number of value-added competencies which were not previously possible with the traditional analog review of these slides under a microscope by a pathologist. As an important tool for investigational research, digital pathology can leverage the quantification and reproducibility offered by image analysis to add value to the pathology field. This chapter will focus on the application of image analysis to investigate the tumor microenvironment and how quantitative investigation can provide deeper insight into our understanding of the tumor to tumor microenvironment relationship.

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Author information

Authors and Affiliations

  1. Analytic Microscopy Core, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL, 33612, USA

    Mark C. Lloyd, Joseph O. Johnson, Agnieszka Kasprzak & Marilyn M. Bui

  2. Analytic Microscopy Core, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL, 33612, USA

    Marilyn M. Bui

  3. Department of Biological Sciences, University of Chicago Illinois, 845 W. Taylor St., Chicago, IL 60607, USA

    Mark C. Lloyd

Authors
  1. Mark C. Lloyd
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  2. Joseph O. Johnson
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  3. Agnieszka Kasprzak
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  4. Marilyn M. Bui
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Corresponding author

Correspondence to Mark C. Lloyd .

Editor information

Editors and Affiliations

  1. H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA

    Katarzyna A. Rejniak

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© 2016 Springer International Publishing Switzerland

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Lloyd, M.C., Johnson, J.O., Kasprzak, A., Bui, M.M. (2016). Image Analysis of the Tumor Microenvironment. In: Rejniak, K. (eds) Systems Biology of Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 936. Springer, Cham. https://doi.org/10.1007/978-3-319-42023-3_1

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