Abstract
The Gennaris bionic vision system is a wireless device that has been designed to directly stimulate the primary visual cortex to restore useful vision to people with bilateral, irreversible blindness. Here, we describe the end-to-end system and the design of each component. The rationale for design decisions is provided, including the benefits of cortical stimulation, the need for wireless power and data transmission and the format of the autonomous implant tiles and penetrating micro-electrode arrays. We discuss the broad population of people for which this device may provide benefit, with reference to specific indications of blindness.
Details of laboratory and preclinical tests that we have used to verify the electrical functionality of the device are described. A description of the surgical method that has been developed for implanting tiles in the visual cortex is provided, which will be used to demonstrate proof-of-concept of the system in first-in-human studies. Highlighted is the importance of post-surgical device calibration, psychophysics testing and training of recipients in using the system in both controlled and unsupervised environments. Signal processing algorithms that have been developed to enhance the user experience are described and details provided of how these have been tested to optimise their integration into the full system. Finally, we describe how the Gennaris technology can be applied to a broad spectrum of other technological and health-related challenges.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunton EK, et al. In vivo comparison of the charge densities required to evoke motor responses using novel annular penetrating microelectrodes. Front Neuroeng. 2015; doi:10.3389/fneng.2015.00005.
Dobelle WH. Artificial vision for the blind by connecting a television camera to the visual cortex. ASAIO J. 2000;46:3–9.
Hilgetag CC, Barbas H. Role of mechanical factors in the morphology of the primate cerebral cortex. PLoS Comput Biol. 2006;2(3):e22.
Josh H, et al. 2012. Mobile, real-time simulator for a cortical visual prosthesis. Paper presented at BioDevices 2012 – Proceedings of the International Conference on Biomedical Electronics and Devices, Portugal. p. 37–46.
Lewis PM, et al. Restoration of vision in blind individuals using bionic devices: a review with a focus on cortical visual prostheses. Brain Res. 2015;1595:51–7.
Lowery AJ, et al. 2015. Restoration of vision using wireless cortical implants: the Monash Vision Group Project. Presented at the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milan, Paper WeBPoT14.8.
Schmidt EM, et al. Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain. 1996;119(Pt 2):507–22.
Wang C, et al. Characteristics of electrode impedance and stimulation efficacy of a chronic cortical implant using novel annulus electrodes in rat motor cortex. J Neural Eng. 2013;10(4):046010.
Acknowledgement
Special acknowledgement goes to Dr. Collette Mann, who sadly passed away before publication of this Book. As Monash Vision Group’s Clinical Coordinator, Dr. Mann’s contribution to this Chapter included the generation of human response data using our Hatpack bionic vision simulator, in addition to proof reading Chapter content.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Lowery, A.J. et al. (2017). Monash Vision Group’s Gennaris Cortical Implant for Vision Restoration. In: Gabel, V. (eds) Artificial Vision. Springer, Cham. https://doi.org/10.1007/978-3-319-41876-6_17
Download citation
DOI: https://doi.org/10.1007/978-3-319-41876-6_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-41874-2
Online ISBN: 978-3-319-41876-6
eBook Packages: MedicineMedicine (R0)