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Pulmonary Infections in Acute Respiratory Distress Syndrome

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Acute Respiratory Distress Syndrome

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References

  1. Johanson WG, Holcomb JR, Coalson JJ (1982) Experimental diffuse alveolar damage in baboons. Am Rev Respir Dis 126:142–151

    PubMed  Google Scholar 

  2. Campbell GD, Coalson JJ, Johanson WG (1984) The effect of bacterial superinfection on lung function after diffuse alveolar damage. Am Rev Respir Dis 129:974–978

    CAS  PubMed  Google Scholar 

  3. Dudeck MA, Edwards JR, Allen-Bridson K, Gross C, Malpiedi PJ, Peterson KD, Pollock DA, Weiner LM, Sievert DM (2015) National Healthcare Safety Network report, data summary for 2013, Device-associated Module. Am J Infect Control 43:206–221

    Article  PubMed  Google Scholar 

  4. Dudeck MA, Weiner LM, Allen-Bridson K, Malpiedi PJ, Peterson KD, Pollock DA, Sievert DM, Edwards JR (2013) National Healthcare Safety Network (NHSN) report, data summary for 2012, Device-associated module. Am J Infect Control 41:1148–1166

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wang Y, Eldridge N, Metersky ML, Verzier NR, Meehan TP, Pandolfi MM, Foody JM, Ho SY, Galusha D, Kliman RE, Sonnenfeld N, Krumholz HM, Battles J (2014) National trends in patient safety for four common conditions, 2005-2011. N Engl J Med 370:341–351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chastre J, Trouillet JL, Vuagnat A, Joly-Guillou ML, Clavier H, Dombret MC, Gibert C (1998) Nosocomial pneumonia in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 157:1165–1172

    Article  CAS  PubMed  Google Scholar 

  7. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, Haren FV, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A (2016) Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA 315:788–800

    Article  CAS  PubMed  Google Scholar 

  8. Markowicz P, Wolff M, Djedaïni K, Cohen Y, Chastre J, Delclaux C, Merrer J, Herman B, Veber B, Fontaine A, Dreyfuss D (2000) Multicenter prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome. Incidence, prognosis, and risk factors. ARDS Study Group. Am J Respir Crit Care Med 161:1942–1948

    Article  CAS  PubMed  Google Scholar 

  9. Wolkewitz M, Cooper BS, Bonten MJ, Barnett AG, Schumacher M (2014) Interpreting and comparing risks in the presence of competing events. BMJ 349:g5060

    Article  PubMed  Google Scholar 

  10. Melsen WG, Rovers MM, Groenwold RH, Bergmans DC, Camus C, Bauer TT, Hanisch EW, Klarin B, Koeman M, Krueger WA, Lacherade JC, Lorente L, Memish ZA, Morrow LE, Nardi G, van Nieuwenhoven CA, O’Keefe GE, Nakos G, Scannapieco FA, Seguin P, Staudinger T, Topeli A, Ferrer M, Bonten MJ (2013) Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 13:665–671

    Article  PubMed  Google Scholar 

  11. Bekaert M, Timsit JF, Vansteelandt S, Depuydt P, Vésin A, Garrouste-Orgeas M, Decruyenaere J, Clec’h C, Azoulay E, Benoit D (2011) Outcomerea Study Group: Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis. Am J Respir Crit Care Med 184:1133–1139

    Article  PubMed  Google Scholar 

  12. Timsit JF, Zahar JR, Chevret S (2011) Attributable mortality of ventilator-associated pneumonia. Curr Opin Crit Care 17:464–471

    Article  PubMed  Google Scholar 

  13. Nordin U (1977) The trachea and cuff-induced tracheal injury An experimental study on causative factors and prevention. Acta Otolaryngol Suppl 345:1–71

    CAS  PubMed  Google Scholar 

  14. Li Bassi G, Ranzani OT, Marti JD, Giunta V, Luque N, Isetta V, Ferrer M, Farre R, Pimentel GL, Torres A (2013) An in vitro study to assess determinant features associated with fluid sealing in the design of endotracheal tube cuffs and exerted tracheal pressures. Crit Care Med 41:518–526

    Article  PubMed  Google Scholar 

  15. Inglis TJ, Millar MR, Jones JG, Robinson DA (1989) Tracheal tube biofilm as a source of bacterial colonization of the lung. J Clin Microbiol 27:2014–2018

    CAS  PubMed  PubMed Central  Google Scholar 

  16. De Souza PR, De Andrade D, Cabral DB, Watanabe E (2014) Endotracheal tube biofilm and ventilator-associated pneumonia with mechanical ventilation. Microsc Res Tech 77:305–312

    Article  PubMed  Google Scholar 

  17. Gil-Perotin S, Ramirez P, Marti V, Sahuquillo JM, Gonzalez E, Calleja I, Menendez R, Bonastre J (2012) Implications of endotracheal tube biofilm in ventilator-associated pneumonia response: a state of concept. Crit Care 16:R93

    Article  PubMed  PubMed Central  Google Scholar 

  18. Wilson A, Gray D, Karakiozis J, Thomas J (2012) Advanced endotracheal tube biofilm stage, not duration of intubation, is related to pneumonia. J Trauma Acute Care Surg 72:916–923

    Article  PubMed  Google Scholar 

  19. Shah C, Kollef MH (2004) Endotracheal tube intraluminal volume loss among mechanically ventilated patients. Crit Care Med 32:120–125

    Article  PubMed  Google Scholar 

  20. Johanson WG, Pierce AK, Sanford JP, Thomas GD (1972) Nosocomial respiratory infections with gram-negative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med 77:701–706

    Article  PubMed  Google Scholar 

  21. Golin V, Mimica IM, Mimica LM (1998) Oropharynx microbiota among alcoholics and non-alcoholics. Sao Paulo Med J 116:1727–1733

    Article  CAS  PubMed  Google Scholar 

  22. Fuxench-López Z, Ramírez-Ronda CH (1978) Pharyngeal flora in ambulatory alcoholic patients: prevalence of gram-negative bacilli. Arch Intern Med 138:1815–1816

    Article  PubMed  Google Scholar 

  23. Mackowiak PA, Martin RM, Jones SR, Smith JW (1978) Pharyngeal colonization by gram-negative bacilli in aspiration-prone persons. Arch Intern Med 138:1224–1227

    Article  CAS  PubMed  Google Scholar 

  24. Frandah W, Colmer-Hamood J, Mojazi Amiri H, Raj R, Nugent K (2013) Oropharyngeal flora in patients admitted to the medical intensive care unit: clinical factors and acid suppressive therapy. J Med Microbiol 62:778–784

    Article  PubMed  Google Scholar 

  25. Mackowiak PA, Martin RM, Smith JW (1979) The role of bacterial interference in the increased prevalence of oropharyngeal gram-negative bacilli among alcoholics and diabetics. Am Rev Respir Dis 120:589–593

    CAS  PubMed  Google Scholar 

  26. Scannapieco FA, Bush RB, Paju S (2003) Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Ann Periodontol 8:54–69

    Article  PubMed  Google Scholar 

  27. Dennesen P, van der Ven A, Vlasveld M, Lokker L, Ramsay G, Kessels A, van den Keijbus P, van Nieuw AA, Veerman E (2003) Inadequate salivary flow and poor oral mucosal status in intubated intensive care unit patients. Crit Care Med 31:781–786

    Article  PubMed  Google Scholar 

  28. Ayars GH, Altman LC, Fretwell MD (1982) Effect of decreased salivation and pH on the adherence of Klebsiella species to human buccal epithelial cells. Infect Immun 38:179–182

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Gibbons RJ, Etherden I (1986) Fibronectin-degrading enzymes in saliva and their relation to oral cleanliness. J Periodontal Res 21:386–395

    Article  CAS  PubMed  Google Scholar 

  30. Nakamura M, Slots J (1983) Salivary enzymes. Origin and relationship to periodontal disease. J Periodontal Res 18:559–569

    Article  CAS  PubMed  Google Scholar 

  31. Scannapieco FA (1999) Role of oral bacteria in respiratory infection. J Periodontol 70:793–802

    Article  CAS  PubMed  Google Scholar 

  32. Fourrier F, Duvivier B, Boutigny H, Roussel-Delvallez M, Chopin C (1998) Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients. Crit Care Med 26:301–308

    Article  CAS  PubMed  Google Scholar 

  33. Torres A, El-Ebiary M, Soler N, Montón C, Fàbregas N, Hernández C (1996) Stomach as a source of colonization of the respiratory tract during mechanical ventilation: association with ventilator-associated pneumonia. Eur Respir J 9:1729–1735

    Article  CAS  PubMed  Google Scholar 

  34. Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C, Caspani L, Raimondi F, Bordone G, Iapichino G, Mancebo J, Guérin C, Ayzac L, Blanch L, Fumagalli R, Tognoni G, Gattinoni L, Prone-Supine II (2009) Study Group: Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 302:1977–1984

    Article  CAS  PubMed  Google Scholar 

  35. Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V, Malacrida R, Di Giulio P, Fumagalli R, Pelosi P, Brazzi L, Latini R (2001) Prone-Supine Study Group: Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 345:568–573

    Article  CAS  PubMed  Google Scholar 

  36. Benjamin R, Chapman G, Kim C, Sackner M (1989) Removal of bronchial secretions by two-phase gas-liquid transport. Chest 95:658–663

    Article  CAS  PubMed  Google Scholar 

  37. Sackner MA, Hirsch J, Epstein S (1975) Effect of cuffed endotracheal tubes on tracheal mucous velocity. Chest 68:774–777

    Article  CAS  PubMed  Google Scholar 

  38. Sackner MA, Hirsch JA, Epstein S, Rywlin AM (1976) Effect of oxygen in graded concentrations upon tracheal mucous velocity. A study in anesthetized dogs. Chest 69:164–167

    Article  CAS  PubMed  Google Scholar 

  39. Hirsch JA, Tokayer JL, Robinson MJ, Sackner MA (1975) Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. J Appl Physiol 39:242–246

    CAS  PubMed  Google Scholar 

  40. Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P (2013) Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 187:1287–1293

    Article  CAS  PubMed  Google Scholar 

  41. Headley AS, Tolley E, Meduri GU (1997) Infections and the inflammatory response in acute respiratory distress syndrome. Chest 111:1306–1321

    Article  CAS  PubMed  Google Scholar 

  42. Nakos G, Malamou-Mitsi VD, Lachana A, Karassavoglou A, Kitsiouli E, Agnandi N, Lekka ME (2002) Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma. Crit Care Med 30:1488–1494

    Google Scholar 

  43. Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P. (2013) Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 187:1287–93

    Google Scholar 

  44. Delclaux C, Roupie E, Blot F, Brochard L, Lemaire F, Brun-Buisson C (1997) Lower respiratory tract colonization and infection during severe acute respiratory distress syndrome: incidence and diagnosis. Am J Respir Crit Care Med 156:1092–1098

    Article  CAS  PubMed  Google Scholar 

  45. Fagon JY, Chastre J (2003) Diagnosis and treatment of nosocomial pneumonia in ALI/ARDS patients. Eur Respir J Suppl 42:77s–83s

    Article  CAS  PubMed  Google Scholar 

  46. Combes A, Figliolini C, Trouillet JL, Kassis N, Wolff M, Gibert C, Chastre J (2002) Incidence and outcome of polymicrobial ventilator-associated pneumonia. Chest 121:1618–1623

    Article  PubMed  Google Scholar 

  47. Schwebel C, Clec’h C, Magne S, Minet C, Garrouste-Orgeas M, Bonadona A, Dumenil AS, Jamali S, Kallel H, Goldgran-Toledano D, Marcotte G, Azoulay E, Darmon M, Ruckly S, Souweine B, Timsit JF (2013) OUTCOMEREA Study Group: Safety of intrahospital transport in ventilated critically ill patients: a multicenter cohort study*. Crit Care Med 41:1919–1928

    Article  PubMed  Google Scholar 

  48. Kollef MH, Von Harz B, Prentice D, Shapiro SD, Silver P, St John R, Trovillion E (1997) Patient transport from intensive care increases the risk of developing ventilator-associated pneumonia. Chest 112:765–773

    Article  CAS  PubMed  Google Scholar 

  49. Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477

    Article  CAS  PubMed  Google Scholar 

  50. Schweickert WD, Gehlbach BK, Pohlman AS, Hall JB, Kress JP (2004) Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 32:1272–1276

    Article  PubMed  Google Scholar 

  51. Strøm T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375:475–480

    Article  PubMed  Google Scholar 

  52. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373:1874–1882

    Article  PubMed  Google Scholar 

  53. Langer T, Santini A, Bottino N, Crotti S, Batchinsky AI, Pesenti A, Gattinoni L (2016) "Awake" extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering. Crit Care 20:150

    Google Scholar 

  54. Hoeper MM, Wiesner O, Hadem J, Wahl O, Suhling H, Duesberg C, Sommer W, Warnecke G, Greer M, Boenisch O, Busch M, Kielstein JT, Schneider A, Haverich A, Welte T, Kühn C (2013) Extracorporeal membrane oxygenation instead of invasive mechanical ventilation in patients with acute respiratory distress syndrome. Intensive Care Med 39:2056–7.

    Google Scholar 

  55. Dullenkopf A, Gerber A, Weiss M (2003) Fluid leakage past tracheal tube cuffs: evaluation of the new Microcuff endotracheal tube. Intensive Care Med 29:1849–1853

    Article  PubMed  Google Scholar 

  56. Lorente L, Lecuona M, Jiménez A, Mora ML, Sierra A (2007) Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Respir Crit Care Med 176:1079–1083

    Article  PubMed  Google Scholar 

  57. Miller MA, Arndt JL, Konkle MA, Chenoweth CE, Iwashyna TJ, Flaherty KR, Hyzy RC (2011) A polyurethane cuffed endotracheal tube is associated with decreased rates of ventilator-associated pneumonia. J Crit Care 26:280–286

    Article  PubMed  Google Scholar 

  58. Poelaert J, Haentjens P, Blot S (2014) Association among duration of mechanical ventilation, cuff material of endotracheal tube, and postoperative nosocomial pneumonia in cardiac surgical patients: A prospective study. J Thorac Cardiovasc Surg 148:1622–1627

    Article  PubMed  Google Scholar 

  59. Poelaert J, Depuydt P, De Wolf A, Van de Velde S, Herck I, Blot S (2008) Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surgery: a pilot study. J Thorac Cardiovasc Surg 135:771–776

    Article  PubMed  Google Scholar 

  60. Philippart F, Gaudry S, Quinquis L, Lau N, Ouanes I, Touati S, Nguyen JC, Branger C, Faibis F, Mastouri M, Forceville X, Abroug F, Ricard JD, Grabar S, Misset B (2015) TOP-Cuff Study Group: Randomized intubation with polyurethane or conical cuffs to prevent pneumonia in ventilated patients. Am J Respir Crit Care Med 191:637–645

    Article  CAS  PubMed  Google Scholar 

  61. Lucangelo U, Zin WA, Antonaglia V, Petrucci L, Viviani M, Buscema G, Borelli M, Berlot G (2008) Effect of positive expiratory pressure and type of tracheal cuff on the incidence of aspiration in mechanically ventilated patients in an intensive care unit. Crit Care Med 36:409–413

    Article  PubMed  Google Scholar 

  62. Nseir S, Zerimech F, Fournier C, Lubret R, Ramon P, Durocher A, Balduyck M (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients. Am J Respir Crit Care Med 184:1041–1047

    Article  PubMed  Google Scholar 

  63. Rouzé A, Nseir S (2013) Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients: where is the evidence? Curr Opin Crit Care 19:440–447

    Article  PubMed  Google Scholar 

  64. Valencia M, Ferrer M, Farre R, Navajas D, Badia JR, Nicolas JM, Torres A (2007) Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial. Crit Care Med 35:1543–1549

    Article  PubMed  Google Scholar 

  65. Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK (2011) Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 39:1985–1991

    Article  PubMed  Google Scholar 

  66. Høiby N, Bjarnsholt T, Moser C, Bassi GL, Coenye T, Donelli G, Hall-Stoodley L, Holá V, Imbert C, Kirketerp-Møller K, Lebeaux D, Oliver A, Ullmann AJ, Williams C (2014) ESCMID Study Group for Biofilms (ESGB) and Consulting External Expert Werner Zimmerli: ESCMID guideline for Markowicz 2015; i37–i40

    Google Scholar 

  67. Kollef MH, Afessa B, Anzueto A, Veremakis C, Kerr KM, Margolis BD, Craven DE, Roberts PR, Arroliga AC, Hubmayr RD, Restrepo MI, Auger WR, Schinner R (2008) NASCENT Investigation Group: Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA 300:805–813

    Article  CAS  PubMed  Google Scholar 

  68. Torres A, Serra-Batlles J, Ros E, Piera C (1992) Puig de la Bellacasa J, Cobos A, Lomeña F, Rodríguez-Roisin R: Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med 116:540–543

    Article  CAS  PubMed  Google Scholar 

  69. Orozco-Levi M, Torres A, Ferrer M (1995) Piera C, el-Ebiary M, de la Bellacasa JP, Rodriguez-Roisin R: Semirecumbent position protects from pulmonary aspiration but not completely from gastroesophageal reflux in mechanically ventilated patients. Am J Respir Crit Care Med 152:1387–1390

    Article  CAS  PubMed  Google Scholar 

  70. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354:1851–1858

    Article  CAS  PubMed  Google Scholar 

  71. Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L (2013) PROSEVA Study Group: Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:2159–2168

    Article  PubMed  Google Scholar 

  72. Ayzac L, Girard R, Baboi L, Beuret P, Rabilloud M, Richard JC, Guérin C (2015) Ventilator-associated pneumonia in ARDS patients: the impact of prone positioning. A secondary analysis of the PROSEVA trial. Intensive Care Med 42:871–878

    Article  PubMed  Google Scholar 

  73. Tejerina E, Esteban A, Fernández-Segoviano P, Frutos-Vivar F, Aramburu J, Ballesteros D, Rodríguez-Barbero JM (2010) Accuracy of clinical definitions of ventilator-associated pneumonia: comparison with autopsy findings. J Crit Care 25:62–68

    Article  PubMed  Google Scholar 

  74. Fàbregas N, Ewig S, Torres A, El-Ebiary M, Ramirez J, de La Bellacasa JP, Bauer T, Cabello H (1999) Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax 54:867–873

    Article  PubMed  PubMed Central  Google Scholar 

  75. Andrews CP, Coalson JJ, Smith JD, Johanson WG (1981) Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury. Chest 80:254–258

    Article  CAS  PubMed  Google Scholar 

  76. Lefcoe MS, Fox GA, Leasa DJ, Sparrow RK, McCormack DG (1994) Accuracy of portable chest radiography in the critical care setting. Diagnosis of pneumonia based on quantitative cultures obtained from protected brush catheter. Chest 105:885–887

    Article  CAS  PubMed  Google Scholar 

  77. Wunderink RG (2000) Radiologic diagnosis of ventilator-associated pneumonia. Chest 117:188S–190S

    Article  CAS  PubMed  Google Scholar 

  78. Wunderink RG, Woldenberg LS, Zeiss J, Day CM, Ciemins J, Lacher DA (1992) The radiologic diagnosis of autopsy-proven ventilator-associated pneumonia. Chest 101:458–463

    Article  CAS  PubMed  Google Scholar 

  79. Meduri GU, Mauldin GL, Wunderink RG, Leeper KV, Jones CB, Tolley E, Mayhall G (1994) Causes of fever and pulmonary densities in patients with clinical manifestations of ventilator-associated pneumonia. Chest 106:221–235

    Article  CAS  PubMed  Google Scholar 

  80. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM (1991) Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 143:1121–1129

    Article  CAS  PubMed  Google Scholar 

  81. Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL (2000) Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 162:505–511

    Article  CAS  PubMed  Google Scholar 

  82. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, Napolitano LM, O’Grady NP, Bartlett JG, Carratalà J, El Solh AA, Ewig S, Fey PD, File TM, Restrepo MI, Roberts JA, Waterer GW, Cruse P, Knight SL, Brozek JL (2016) Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 63:575–582

    Article  PubMed  Google Scholar 

  83. Canadian Critical Care Trials Group (2006) A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 355:2619–2630

    Article  Google Scholar 

  84. Sanchez-Nieto JM, Torres A, Garcia-Cordoba F, El-Ebiary M, Carrillo A, Ruiz J, Nuñez ML, Niederman M (1998) Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot study. Am J Respir Crit Care Med 157:371–376

    Article  CAS  PubMed  Google Scholar 

  85. Solé Violán J, Fernández JA, Benítez AB, Cardeñosa Cendrero JA (2000) Rodríguez de Castro F: Impact of quantitative invasive diagnostic techniques in the management and outcome of mechanically ventilated patients with suspected pneumonia. Crit Care Med 28:2737–2741

    Article  PubMed  Google Scholar 

  86. Ruiz M, Torres A, Ewig S, Marcos MA, Alcón A, Lledó R, Asenjo MA, Maldonaldo A (2000) Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia: evaluation of outcome. Am J Respir Crit Care Med 162:119–125

    Article  CAS  PubMed  Google Scholar 

  87. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stéphan F, Similowski T, Mercat A, Diehl JL, Sollet JP, Tenaillon A (2000) Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med 132:621–630

    Article  CAS  PubMed  Google Scholar 

  88. Berton DC, Kalil AC, Teixeira PJ (2014) Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev 10:CD006482

    Google Scholar 

  89. Meduri GU, Reddy RC, Stanley T, El-Zeky F (1998) Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling. Am J Respir Crit Care Med 158:870–875

    Article  CAS  PubMed  Google Scholar 

  90. Rouby JJ, Martin De Lassale E, Poete P, Nicolas MH, Bodin L, Jarlier V, Le Charpentier Y, Grosset J, Viars P (1992) Nosocomial bronchopneumonia in the critically ill. Histologic and bacteriologic aspects. Am Rev Respir Dis 146:1059–1066

    Article  CAS  PubMed  Google Scholar 

  91. Nair GB, Niederman MS (2015) Ventilator-associated pneumonia: present understanding and ongoing debates. Intensive Care Med 41:34–48

    Article  PubMed  Google Scholar 

  92. Kollef MH, Ward S, Sherman G, Prentice D, Schaiff R, Huey W, Fraser VJ (2000) Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med 28:3456–3464

    Article  CAS  PubMed  Google Scholar 

  93. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH (2002) Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 122:262–268

    Article  PubMed  Google Scholar 

  94. Luna CM, Aruj P, Niederman MS, Garzón J, Violi D, Prignoni A, Ríos F, Baquero S, Gando S (2006) Grupo Argentino de Estudio de la Neumonía Asociada al Respirador group: Appropriateness and delay to initiate therapy in ventilator-associated pneumonia. Eur Respir J 27:158–164

    Article  CAS  PubMed  Google Scholar 

  95. Kuti EL, Patel AA, Coleman CI (2008) Impact of inappropriate antibiotic therapy on mortality in patients with ventilator-associated pneumonia and blood stream infection: a meta-analysis. J Crit Care 23:91–100

    Article  PubMed  Google Scholar 

  96. Hanberger H, Garcia-Rodriguez JA, Gobernado M, Goossens H, Nilsson LE, Struelens MJ (1999) Antibiotic susceptibility among aerobic gram-negative bacilli in intensive care units in 5 European countries. French and Portuguese ICU Study Groups. JAMA 281:67–71

    Article  CAS  PubMed  Google Scholar 

  97. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J (1999) Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 160:608–613

    Article  CAS  PubMed  Google Scholar 

  98. Martin-Loeches I, Deja M, Koulenti D, Dimopoulos G, Marsh B, Torres A, Niederman MS, Rello J (2013) EU-VAP Study Investigators: Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med 39:672–681

    Article  PubMed  Google Scholar 

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Correspondence to Gianluigi Li Bassi MD, PhD .

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Bassi, G.L., Sanussi, T., Pelosi, P., Ranzani, O.T. (2017). Pulmonary Infections in Acute Respiratory Distress Syndrome. In: Chiumello, D. (eds) Acute Respiratory Distress Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-41852-0_20

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