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Prognostic Factors for Ductal Carcinoma in Situ of the Breast

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Molecular Pathology of Breast Cancer

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Abstract

Ductal carcinoma in situ of the breast is a non-obligate precursor for the development of invasive carcinoma of the breast. A number of clinical and pathologic parameters have been traditionally used to stratify cases based on the likelihood of recurrence. These include patient age, completeness of excision, method of presentation, and histologic features. Immunohistochemistry-based analysis of expression of various molecular markers have also been used to define risk of recurrence. The use of imaging studies such as magnetic resonance imaging (MRI) have not added significantly to mammography in improving local control. More recently, molecular profiling, including a gene expression-based assay, has become commercially available. Assays such as this can be successfully used to stratify patients into risk groups for clinical decision-making.

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Authors and Affiliations

  1. Department of Radiation Oncology, Albert Einstein Healthcare Network, Philadelphia, PA, USA

    Lawrence J. Solin

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  1. Lawrence J. Solin
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Correspondence to Lawrence J. Solin .

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Editors and Affiliations

  1. Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

    Sunil Badve

  2. Indiana University School of Medicine, Dept of Pathology & Laboratory Medicine Indiana University School of Medicine, Indianapolis, Indiana, USA

    Yesim Gökmen-Polar

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Solin, L.J. (2016). Prognostic Factors for Ductal Carcinoma in Situ of the Breast. In: Badve, S., Gökmen-Polar, Y. (eds) Molecular Pathology of Breast Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-41761-5_17

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