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Adiponectin, Obesity, and Cancer

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Adipocytokines, Energy Balance, and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 12))

Abstract

The worst outcomes of cancer, such as recurrence and mortality, are associated with obesity. Adiponectin is a fat-derived hormone and an important regulator of cell growth and tissue remodeling. Secreted exclusively from adipocytes into the peripheral blood, adiponectin contributes to tumor progression by acting locally and at distant sites. Contrary to expectations, adiponectin is decreased in obesity providing a link to tumorigenesis. Herein, we consider adiponectin’s structure and post-translational modifications as critical determinants of its activity and receptor-binding ability. The cellular signaling pathways affected by the presence of adiponectin are discussed in the context of malignancy along with the leptin/adiponectin (L/A) ratio as an adjunctive tool in recurrence prediction. While the mechanisms involved in the paradoxical relationship between adiponectin, obesity, and cancer remain obscure, adiponectin replacement-based therapies may represent a novel preventative approach to diminish the incidence and mortality from obesity-associated cancers.

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Authors and Affiliations

  1. Helmholtz Zentrum Munich, Institute of Radiation Biology, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany

    V. B. O’Leary Ph.D.

  2. Department of Pathobiology, Lerner Research Institute (NE4-209), The Cleveland Clinic Foundation, Case Western Reserve University Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    J. P. Kirwan Ph.D.

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Correspondence to J. P. Kirwan Ph.D. .

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  1. Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Ofer Reizes

  2. Center for Science, Health and Society, Case Western Reserve University, Cleveland, Ohio, USA

    Nathan A. Berger

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O’Leary, V.B., Kirwan, J.P. (2017). Adiponectin, Obesity, and Cancer. In: Reizes, O., Berger, N. (eds) Adipocytokines, Energy Balance, and Cancer. Energy Balance and Cancer, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-41677-9_2

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