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Role of C-Reactive Protein in Cancer

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Adipocytokines, Energy Balance, and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 12))

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Abstract

Low-grade chronic inflammation is a proposed mechanism linking excess body weight with cancer development. Adipocytes, particularly visceral fat cells, regularly release pro-inflammatory cytokines likely due to hypoxic and necrotic conditions in conglomerated fat tissue in obese individuals. C-reactive protein (CRP), a long-established acute-phase reactant, is triggered primarily by the cytokine Interleukin-6, as part of the innate immune system apparatus to resolve acute infection, injury, and inflammation. Some but not all epidemiologic studies suggest that low-grade circulating CRP levels predict cancer development, particularly for lung and colon cancers. Evidence as a prognostic factor, however, is more convincing, but whether or not elevated CRP reflects inflammation associated with large, aggressive neoplasms or solely serves as a general marker of mortality risk needs clarification.

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Authors and Affiliations

  1. Department of Community Medicine and Health Care, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Helen Swede Ph.D.

  2. Department of Epidemiology and Biostatistics, University of California San Francisco, 550 16th Street, San Francisco, CA, 94158, USA

    Dejana Braithwaite Ph.D.

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  1. Helen Swede Ph.D.
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Correspondence to Helen Swede Ph.D. .

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  1. Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Ofer Reizes

  2. Center for Science, Health and Society, Case Western Reserve University, Cleveland, Ohio, USA

    Nathan A. Berger

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Swede, H., Braithwaite, D. (2017). Role of C-Reactive Protein in Cancer. In: Reizes, O., Berger, N. (eds) Adipocytokines, Energy Balance, and Cancer. Energy Balance and Cancer, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-41677-9_10

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