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Adipocytes, Adipocytokines, and Cancer

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Adipocytokines, Energy Balance, and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 12))

Abstract

Obesity is now a well-established promoter of cancer progression and decreased overall patient survival. Ever since the association between obesity and cancer was appreciated, adipose tissue, adipocytes, and secreted fat-derived factors have been a focus of the mechanism underlying this link. Adipose-secreted factors cytokines are referred to as adipocytokines and represent the group of molecules thought to link adipose or fat cells to initiation and promotion of various cancers. There are over 20 identified adipokines, of which, a subset has been implicated in cancer. In this chapter, we will provide a concise review of the current literature on the subset of adipose-derived factors linked to cancer.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195, USA

    Caner Saygin M.D. & Ofer Reizes Ph.D.

  2. Department of Cellular and Molecular Medicine, Case Comprehensive Cancer Center, Case Western Reserve University Lerner College of Medicine, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195, USA

    Ofer Reizes Ph.D.

  3. Department of Medicine, Biochemistry, Oncology, Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA

    Nathan A. Berger M.D.

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  1. Caner Saygin M.D.
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  2. Ofer Reizes Ph.D.
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  3. Nathan A. Berger M.D.
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Correspondence to Ofer Reizes Ph.D. or Nathan A. Berger M.D. .

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Editors and Affiliations

  1. Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Ofer Reizes

  2. Center for Science, Health and Society, Case Western Reserve University, Cleveland, Ohio, USA

    Nathan A. Berger

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Saygin, C., Reizes, O., Berger, N.A. (2017). Adipocytes, Adipocytokines, and Cancer. In: Reizes, O., Berger, N. (eds) Adipocytokines, Energy Balance, and Cancer. Energy Balance and Cancer, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-41677-9_1

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