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Epigenetics, Energy Balance, and Cancer pp 211–233Cite as

Epigenetics, Obesity, and Colon Cancer

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Part of the book series: Energy Balance and Cancer ((EBAC,volume 11))

Abstract

Obesity is an important risk factor in incidence of colorectal cancer, particularly in males. The molecular underpinnings of increased risk are unclear. Recent work has suggested that altered epigenetic regulation resulting from complex factors related to obesity may play a role in the increased incidence of colon cancer. Here we review the relationship of colon cancer and alterations in epigenetic regulation in obesity. The colon epithelial cell is impacted by multiple signaling inputs subject to alteration in obese individuals including adipokines, alterations in metabolism, changes in intestinal microbiota, and chronic inflammation. Obesity-related changes in these pathways likely result in alterations in the epigenome of colonic epithelial cells, with the potential to influence cancer development and/or progression.

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Acknowledgments

The authors gratefully acknowledge the members of the Wade laboratory for useful discussions and feedback provided during the course of this work. This work was supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ES101965 to P.A.W.).

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    Ruifang Li & Paul A. Wade

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    Nathan A. Berger

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Li, R., Wade, P.A. (2016). Epigenetics, Obesity, and Colon Cancer. In: Berger, N. (eds) Epigenetics, Energy Balance, and Cancer. Energy Balance and Cancer, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-41610-6_9

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