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Adhesion GPCRs as Modulators of Immune Cell Function

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Adhesion G Protein-coupled Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 234))

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Abbreviations

7TM:

Seven transmembrane

Ab:

Antibody

ABCA:

ATP-binding cassette transporter

ACAID:

Anterior chamber-associated immune deviation

Ag:

Antigen

AML:

Acute myeloid leukemia

BAI:

Brain-specific angiogenesis inhibitor

BDCA:

Blood dendritic cell antigen

CTF:

C-terminal fragment

DC:

Dendritic cell

EGF:

Epidermal growth factor

ELMO:

Engulfment and cell motility

EMR:

EGF-like module-containing mucin-like hormone receptor-like

GAIN:

GPCR autoproteolysis inducing

GEF:

Guanine nucleotide exchange factor

GPCR:

G protein-coupled receptor

GPS:

GPCR proteolysis site

HDL:

High-density lipoprotein

HRM:

Hormone receptor motif

HSPC:

Hematopoietic stem and progenitor cell

IFN:

Interferon

IL:

Interleukin

LDL:

Low-density lipoprotein

LPS:

Lipopolysaccharide

mAb:

Monoclonal antibody

Mφ:

Macrophages

NK:

Natural killer

NTF:

N-terminal fragment

PtdSer:

Phosphatidylserine

ROS:

Reactive oxygen species

SIRS:

Systemic inflammatory response syndrome

TGF:

Tumor growth factor

TNF:

Tumor necrosis factor

Treg:

Regulatory T

TSR:

Thrombospondin type 1 repeat

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Acknowledgments

We thank the members of our laboratories for generating a large part of the data discussed in this chapter. This work was supported by grants to J.H. from the Deutsche Forschungsgemeinschaft (Research Unit 2149) and the Thyssen Foundation (2015-00387), to K.S.R. from the National Institutes of Health, USA (GM064709, HD074981, and MH096484), and to H.H.L. from the Ministry of Science and Technology, Taiwan (MOST-104-2320-B-182-035-MY3) and the Chang Gung Memorial Hospital (CMRPD1C0633, CMRPD1D0072-3, and CMRPD1D0392).

Author Contributions J.H., C.C.H., H.H.L., C.S.L., and K.S.R. wrote the manuscript.

Competing Financial Interests The authors declare no competing financial interests.

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Authors and Affiliations

  1. Department of Experimental Immunology, K0-144, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands

    Jörg Hamann & Cheng-Chih Hsiao

  2. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Jordan Hall 7315, Charlottesville, VA, 22908, USA

    Chang Sup Lee & Kodi S. Ravichandran

  3. Department of Microbiology and Immunology, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan

    Hsi-Hsien Lin

  4. Chang Gung Immunology Consortium and Department of Anatomic Pathology, Chang Gung Memorial Hospital-Linkou, Tao-Yuan, 333, Taiwan

    Hsi-Hsien Lin

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  1. Jörg Hamann
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  2. Cheng-Chih Hsiao
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  3. Chang Sup Lee
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  4. Kodi S. Ravichandran
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  5. Hsi-Hsien Lin
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Correspondence to Jörg Hamann or Hsi-Hsien Lin .

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Editors and Affiliations

  1. Institute of Physiology Department of Neurophysiology, University of Würzburg, Würzburg, Germany

    Tobias Langenhan

  2. Institute of Biochemistry Medical Faculty, University of Leipzig, Leipzig, Germany

    Torsten Schöneberg

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Hamann, J., Hsiao, CC., Lee, C.S., Ravichandran, K.S., Lin, HH. (2016). Adhesion GPCRs as Modulators of Immune Cell Function. In: Langenhan, T., Schöneberg, T. (eds) Adhesion G Protein-coupled Receptors. Handbook of Experimental Pharmacology, vol 234. Springer, Cham. https://doi.org/10.1007/978-3-319-41523-9_15

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