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Causes of Chronic Low Back Pain

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Radiofrequency Treatments on the Spine

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Abstract

There is probably no other disease as chronic low back pain (LBP) that has generated a so large amount of literature about, and it is impossible to concentrate all the causes of a so common and diffuse disease. For this reason, we will analyze the most frequent causes as useful as for the main topic of this book, as different causes of LBP generate different treatments. A correct investigation of the correlation between local degenerative changes at the level of the disc and for facet joints and nerves is hard as it’s difficult to obtain complete characterization of the pain (too much variables generating LBP) as well as the possibility to have disc or articular normal samples from a control healthy population. Mice models have been suggested, in a specific population with the secreted protein, acidic, rich in cysteine (SPARC) deficit, this protein being involved in regulating the composition of extracellular matrix. As a consequence, the population of SPARC-null mice usually suffer from an increased disc degeneration, and recent studies suggest the internal disc disruption to be one of the main causes of axial LBP, while no effect has been found about sciatica generation [1].

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Authors and Affiliations

  1. Minimal Invasive Spine Department, Istituto Oncologico Medierraneo, Catania, Italy

    Luigi Manfrè

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  1. Luigi Manfrè
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Correspondence to Luigi Manfrè .

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Editors and Affiliations

  1. Radiology, Santissima Trinita Hospital Radiology, Cagliari, Italy

    Stefano Marcia

  2. Department of Radiology, University of Cagliari Department of Radiology, Cagliari, Italy

    Luca Saba

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Manfrè, L. (2017). Causes of Chronic Low Back Pain. In: Marcia, S., Saba, L. (eds) Radiofrequency Treatments on the Spine. Springer, Cham. https://doi.org/10.1007/978-3-319-41462-1_3

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  • DOI: https://doi.org/10.1007/978-3-319-41462-1_3

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  • Publisher Name: Springer, Cham

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