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The Lysine Acetyltransferases in Cardiovascular Disease

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Epigenetics in Cardiac Disease

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 1))

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Abstract

The lysine acetyltransferases (KATs) are enzymes that catalyze the reversible acetylation of lysine residues within histones, transcription factors, and other proteins. These dynamic and signal-responsive enzymes allow a single pool of nuclear DNA to be interpreted in multiple ways, to create many different cell types, and to carry out a broad range of specialized cell functions. KATs play a particularly important role in adapting the long-lived cells of the cardiovascular system to environmental challenges and changing metabolic states. This chapter will provide an overview of the major classes of mammalian KATs: GNAT, p300/CBP, MYST, and the nuclear receptor coactivators, including CLOCK. Several additional KATs that to date have not been structurally analyzed will also be considered. Special attention will be paid to the role of the KATs in human genetic disorders and in processes important to cardiac and vascular biology.

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Conflict of Interest

I have no conflict of interest related to the material presented here. I am grateful for the support of the National Heart, Lung and Blood Institute (NIH R01 HL071094) and the Miami Heart Research Institute during the writing of this chapter.

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Authors and Affiliations

  1. University of Miami Miller School of Medicine, Miami, FL, USA

    Nanette H. Bishopric MD, FACC, FAHA

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  1. Nanette H. Bishopric MD, FACC, FAHA
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Correspondence to Nanette H. Bishopric MD, FACC, FAHA .

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Editors and Affiliations

  1. Department of Molecular, Cardiology and Epigenetics, University of Heidelberg, Heidelberg, Germany

    Johannes Backs

  2. Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA

    Timothy A. McKinsey

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Bishopric, N.H. (2016). The Lysine Acetyltransferases in Cardiovascular Disease. In: Backs, J., McKinsey, T.A. (eds) Epigenetics in Cardiac Disease. Cardiac and Vascular Biology, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-41457-7_7

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