Histone Methylation in Heart Development and Cardiovascular Disease
Cardiovascular development and homeostasis are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among transcription factors and histone lysine modifiers plays important role in cardiovascular development and diseases. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe basics of histone methylation, and current body of literature on the role of several common histone methylations and their modifying enzymes in cardiovascular development, congenital and adult heart diseases.
KeywordsCongenital Heart Disease Histone Methylation Hypoplastic Left Heart Syndrome H3K4 Methylation Heart Development
Conflict of Interest
The authors declare that they have no conflict of interest.
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