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Histone Methylation in Heart Development and Cardiovascular Disease

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Epigenetics in Cardiac Disease

Part of the book series: Cardiac and Vascular Biology ((Abbreviated title: Card. vasc. biol.,volume 1))

Abstract

Cardiovascular development and homeostasis are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among transcription factors and histone lysine modifiers plays important role in cardiovascular development and diseases. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe basics of histone methylation, and current body of literature on the role of several common histone methylations and their modifying enzymes in cardiovascular development, congenital and adult heart diseases.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Departments of Internal Medical-Cardiology Division and Molecular Biology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX, USA

    Zhi-Ping Liu

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Correspondence to Zhi-Ping Liu .

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Editors and Affiliations

  1. Department of Molecular, Cardiology and Epigenetics, University of Heidelberg, Heidelberg, Germany

    Johannes Backs

  2. Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA

    Timothy A. McKinsey

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Liu, ZP. (2016). Histone Methylation in Heart Development and Cardiovascular Disease. In: Backs, J., McKinsey, T.A. (eds) Epigenetics in Cardiac Disease. Cardiac and Vascular Biology, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-41457-7_6

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