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Histone Methylation in Heart Development and Cardiovascular Disease

  • Zhi-Ping LiuEmail author
Chapter
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)

Abstract

Cardiovascular development and homeostasis are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among transcription factors and histone lysine modifiers plays important role in cardiovascular development and diseases. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe basics of histone methylation, and current body of literature on the role of several common histone methylations and their modifying enzymes in cardiovascular development, congenital and adult heart diseases.

Keywords

Congenital Heart Disease Histone Methylation Hypoplastic Left Heart Syndrome H3K4 Methylation Heart Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Departments of Internal Medical-Cardiology Division and Molecular BiologyUT Southwestern Medical CenterDallasUSA

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