Sirtuins as Regulators of Cardiac Hypertrophy and Heart Failure

  • Sadhana Samant
  • Mahesh P. GuptaEmail author
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)


Sirtuins are emerging as key regulators of a number of biological functions ranging from cell growth, differentiation to longevity. Mammalian genome encodes seven sirtuins isoform (SIRT1–SIRT7), which are distributed in different compartment of the cells. Sirtuins need NAD+ for their enzymatic reaction. Because of their dependency on NAD, they can respond to energy need of the cells and modulate key enzymatic pathways relevant to the maintenance of cellular health. Throughout the evolution, from prokaryotes to mammals, sirtuins are mainly valued for their ability to bestow cells with efficient adaptation to stress conditions. Sirtuins target histone and nonhistone proteins to ameliorate varied pathophysiologic conditions by controlling gene transcription and fitness of mitochondria. Many sirtuin isoforms have been also studied for their roles in regulating cardiac development and protecting the heart from pathological stress. In this review, we will discuss impact of sirtuins in overall health of the cardiovascular system.


Cardiac Hypertrophy Lysine Residue Werner Syndrome Histone H3K9 Lysine Acetylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



These studies were supported from NIH RO1 grants HL117041 and HL111455 to MPG.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Biological Science DivisionUniversity of Chicago MedicineChicagoUSA
  2. 2.Department of SurgeryUniversity of ChicagoChicagoUSA

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