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Cardiac Autophagy and Its Regulation by Reversible Protein Acetylation

  • Min Xie
  • Joseph A. HillEmail author
Chapter
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)

Abstract

Autophagy is an evolutionarily conserved and strictly regulated process implicated in the pathogenesis of multiple cardiovascular diseases. Autophagy is a multi-step process regulated by an orchestrated profile of molecular signaling pathways. Post-translational protein modifications, including reversible acetylation, regulate autophagy at the levels of signaling cascades, autophagy-related protein expression, and direct acetylation and trafficking of autophagic components. Autophagy has been implicated in cardiac hypertrophy, heart failure, ischemia/reperfusion injury, anticancer drug-induced cardiomyopathy and glycogen storage diseases. Manipulations of autophagy by HDAC inhibition is a novel strategy worthy of consideration in the treatment of these common cardiovascular diseases.

Keywords

HDAC Inhibitor Left Ventricular Assist Device Malignant Peripheral Nerve Sheath Tumor Glycogen Storage Disease Autophagic Flux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflicts of Interest

None

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Division of Cardiovascular DiseaseUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.UT Southwestern Medical CenterDallasUSA

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