Abstract
Temporomandibular disorders (TMD) are conceptualized as a group of diverse conditions related to the jaw muscles, temporomandibular joint (TMJ) and related tissues and may be associated with pain, limitations in jaw movements and noises in the TMJ. It is generally agreed that TMD just represents an umbrella term, and intensive work has been devoted to establish specific criteria for subsets of TMDs which are both reliable and valid. This has been achieved with the Diagnostic Criteria for TMD (DC/TMD) (Schiffman et al., J Oral Facial Pain Headache 28(1):6–27, 2014), and all main diagnoses now have known reliability, sensitivity and specificity values which are unique for any pain classification system. One of the new diagnoses in the DC/TMD is headache attributed to TMD (HATMD) (Schiffman et al., Cephalalgia 32(9):683–692, 2012; Schiffman et al., J Oral Facial Pain Headache 28(1):6–27, 2014) which clearly indicates that there is a close overlap between some of the many headache types and some of the painful TMDs. It may be useful from a clinical perspective to recognize some of the similarities in clinical presentation but also to try to identify potential differences in symptomatology as well as underlying pain mechanisms and management. This chapter will first provide an overview of the clinical presentations and overlaps between TMD and headache. Some of the basic mechanisms related to nociception from musculoskeletal tissues, peripheral and central sensitization and endogenous inhibitory controls will then be discussed with particular reference to TMDs.
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References
The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.
Abboud J, Marchand AA, Sorra K, Descarreaux M. Musculoskeletal physical outcome measures in individuals with tension-type headache: a scoping review. Cephalalgia. 2013;33(16):1319–36.
Alstergren P, Ernberg M, Kvarnstrom M, Kopp S. Interleukin-1beta in synovial fluid from the arthritic temporomandibular joint and its relation to pain, mobility, and anterior open bite. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. 1998;56(9):1059–65; discussion 1066.
Ashina M, Bendtsen L, Jensen R, Lassen LH, Sakai F, Olesen J. Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache. Brain J Neurol. 1999;122(Pt 9):1629–35.
Ashina M, Stallknecht B, Bendtsen L, Pedersen JF, Schifter S, Galbo H, Olesen J. Tender points are not sites of ongoing inflammation -in vivo evidence in patients with chronic tension-type headache. Cephalalgia. 2003;23(2):109–16.
Ashina S, Babenko L, Jensen R, Ashina M, Magerl W, Bendtsen L. Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache. Eur J Neurol. 2005;12(7):543–9.
Ashina S, Bendtsen L, Ashina M, Magerl W, Jensen R. Generalized hyperalgesia in patients with chronic tension-type headache. Cephalalgia. 2006;26(8):940–8.
Ayesh EE, Jensen TS, Svensson P. Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints. J Dent Res. 2007;86(12):1187–92.
Balasubramaniam R, de Leeuw R, Zhu H, Nickerson RB, Okeson JP, Carlson CR. Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: a blinded prospective comparison study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(2):204–16.
Ballegaard V, Thede-Schmidt-Hansen P, Svensson P, Jensen R. Are headache and temporomandibular disorders related? A blinded study. Cephalalgia. 2008;28(8):832–41.
Baron R, Forster M, Binder A. Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach. Lancet Neurol. 2012;11(11):999–1005.
Bendtsen L. Central sensitization in tension-type headache – possible pathophysiological mechanisms. Cephalalgia. 2000;20(5):486–508.
Bendtsen L, Fernandez-de-la-Penas C. The role of muscles in tension-type headache. Curr Pain Headache Rep. 2011;15(6):451–8.
Bendtsen L, Jensen R. Tension-type headache: the most common, but also the most neglected, headache disorder. Curr Opin Neurol. 2006;19(3):305–9.
Bevilaqua Grossi D, Lipton RB, Bigal ME. Temporomandibular disorders and migraine chronification. Curr Pain Headache Rep. 2009;13(4):314–8.
Boyer N, Dallel R, Artola A, Monconduit L. General trigeminospinal central sensitization and impaired descending pain inhibitory controls contribute to migraine progression. Pain. 2014;155(7):1196–205.
Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Frequency of headache is related to sensitization: a population study. Pain. 2006;123(1–2):19–27.
Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Increased pain sensitivity is not a risk factor but a consequence of frequent headache: a population-based follow-up study. Pain. 2008;137(3):623–30.
Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain J Neurol. 2000;123(Pt 8):1703–9.
Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010;68(1):81–91.
Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000;47(5):614–24.
Cady RJ, Glenn JR, Smith KM, Durham PL. Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization. Mol Pain. 2011;7:94.
Cairns B. Pathophysiology of TMD pain–basic mechanisms and their implications for pharmacotherapy. J Oral Rehabil. 2010;37(6):391–410.
Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, Arendt-Nielsen L. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res. 2006;169(4):467–72.
Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, Berde CB, Arendt-Nielsen L. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003;90(4):2098–105.
Carli G, Suman AL, Biasi G, Marcolongo R. Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain. Pain. 2002;100(3):259–69.
Cathcart S, Winefield AH, Lushington K, Rolan P. Noxious inhibition of temporal summation is impaired in chronic tension-type headache. Headache. 2010;50(3):403–12.
Chun YH, Frank D, Lee JS, Zhang Y, Auh QS, Ro JY. Peripheral AMPA receptors contribute to muscle nociception and c-fos activation. Neurosci Res. 2008;62(2):97–104.
Clauw DJ. Fibromyalgia and related conditions. Mayo Clin Proc. 2015;90(5):680–92.
Defrin R, Riabinin M, Feingold Y, Schreiber S, Pick CG. Deficient pain modulatory systems in patients with mild traumatic brain and chronic post-traumatic headache: implications for its mechanism. J Neurotrauma. 2015;32(1):28–37.
Della Vedova C, Cathcart S, Dohnalek A, Lee V, Hutchinson MR, Immink MA, Hayball J. Peripheral interleukin-1β levels are elevated in chronic tension-type headache patients. Pain Res Manag: J Can Pain Soc. 2013;18(6):301–6.
Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, Belfer I, Goldman D, Max MB, Weir BS, Maixner W. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet Offic Publ Int Soc Psychiatr Genet. 2006;141b(5):449–62.
Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, Goldman D, Maixner W. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain. 2006;125(3):216–24.
Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005;14(1):135–43.
Drummond PD, Knudsen L. Central pain modulation and scalp tenderness in frequent episodic tension-type headache. Headache. 2011;51(3):375–83.
Ekberg EC, Nilner M. Treatment outcome of short- and long-term appliance therapy in patients with TMD of myogenous origin and tension-type headache. J Oral Rehabil. 2006;33(10):713–21.
Erdal ME, Herken H, Yilmaz M, Bayazit YA. Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine. J Neurol Sci. 2001;188(1–2):99–101.
Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Myofascial trigger points and their relationship to headache clinical parameters in chronic tension-type headache. Headache. 2006;46(8):1264–72.
Fernandez-de-las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Trigger points in the suboccipital muscles and forward head posture in tension-type headache. Headache. 2006;46(3):454–60.
Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Pareja JA. Myofascial trigger points in the suboccipital muscles in episodic tension-type headache. Man Ther. 2006;11(3):225–30.
Fernandez-de-las-Penas C, Ambite-Quesada S, Rivas-Martinez I, Ortega-Santiago R, de-la-Llave-Rincon AI, Fernandez-Mayoralas DM, Pareja JA. Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache. Pediatr Res. 2011;70(4):395–9.
Fernandez-de-Las-Penas C, Cuadrado ML, Arendt-Nielsen L, Ge HY, Pareja JA. Increased pericranial tenderness, decreased pressure pain threshold, and headache clinical parameters in chronic tension-type headache patients. Clin J Pain. 2007;23(4):346–52.
Fernandez-de-Las-Penas C, Cuadrado ML, Pareja JA. Myofascial trigger points, neck mobility, and forward head posture in episodic tension-type headache. Headache. 2007;47(5):662–72.
Fernandez-de-las-Penas C, Galan-del-Rio F, Fernandez-Carnero J, Pesquera J, Arendt-Nielsen L, Svensson P. Bilateral widespread mechanical pain sensitivity in women with myofascial temporomandibular disorder: evidence of impairment in central nociceptive processing. J Pain Offic J Am Pain Soc. 2009;10(11):1170–8.
Fernandez-de-Las-Penas C, Ortega-Santiago R, Cuadrado ML, Lopez-de-Silanes C, Pareja JA. Bilateral widespread mechanical pain hypersensitivity as sign of central sensitization in patients with cluster headache. Headache. 2011;51(3):384–91.
Freund BJ, Schwartz M. Relief of tension-type headache symptoms in subjects with temporomandibular disorders treated with botulinum toxin-A. Headache. 2002;42(10):1033–7.
Garrett PH, Sarlani E, Grace EG, Greenspan JD. Chronic temporomandibular disorders are not necessarily associated with a compromised endogenous analgesic system. J Orofac Pain. 2013;27(2):142–50.
Glaros AG, Urban D, Locke J. Headache and temporomandibular disorders: evidence for diagnostic and behavioural overlap. Cephalalgia. 2007;27(6):542–9.
Gomes MB, Guimaraes JP, Guimaraes FC, Neves AC. Palpation and pressure pain threshold: reliability and validity in patients with temporomandibular disorders. Cranio J Craniomandibular Pract. 2008;26(3):202–10.
Goncalves DA, Camparis CM, Speciali JG, Castanharo SM, Ujikawa LT, Lipton RB, Bigal ME. Treatment of comorbid migraine and temporomandibular disorders: a factorial, double-blind, randomized, placebo-controlled study. J Orofac Pain. 2013;27(4):325–35.
Goncalves DA, Camparis CM, Speciali JG, Franco AL, Castanharo SM, Bigal ME. Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study. Clin J Pain. 2011;27(7):611–5.
Goncalves MC, Florencio LL, Chaves TC, Speciali JG, Bigal ME, Bevilaqua-Grossi D. Do women with migraine have higher prevalence of temporomandibular disorders? Braz J Phys Ther. 2013;17(1):64–8.
Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 2012;64(9):2907–16.
Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA. The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study. J Headache Pain. 2006;7(2):70–4.
Hartung JE, Ciszek BP, Nackley AG. Beta2- and beta3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. Pain. 2014;155(7):1346–55.
King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley 3rd JL. Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder. Pain. 2009;143(3):172–8.
Kocer A, Kocer E, Memisogullari R, Domac FM, Yuksel H. Interleukin-6 levels in tension headache patients. Clin J Pain. 2010;26(8):690–3.
Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain. 2000;88(1):69–78.
Kothari SF, Baad-Hansen L, Oono Y, Svensson P. Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients. Pain. 2015;156(12):2545–55.
Lai TH, Protsenko E, Cheng YC, Loggia ML, Coppola G, Chen WT. Neural plasticity in common forms of chronic headaches. Neural Plast. 2015;2015:205985.
Lam DK, Sessle BJ, Hu JW. Glutamate and capsaicin effects on trigeminal nociception II: activation and central sensitization in brainstem neurons with deep craniofacial afferent input. Brain Res. 2009;1253:48–59.
Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain Offic J Am Pain Soc. 2009;10(9):895–926.
Leblebici B, Pektas ZO, Ortancil O, Hurcan EC, Bagis S, Akman MN. Coexistence of fibromyalgia, temporomandibular disorder, and masticatory myofascial pain syndromes. Rheumatol Int. 2007;27(6):541–4.
Lee YC, Lu B, Edwards RR, Wasan AD, Nassikas NJ, Clauw DJ, Solomon DH, Karlson EW. The role of sleep problems in central pain processing in rheumatoid arthritis. Arthritis Rheum. 2013;65(1):59–68.
Liljestrom MR, Le Bell Y, Anttila P, Aromaa M, Jamsa T, Metsahonkala L, Helenius H, Viander S, Jappila E, Alanen P, Sillanpaa M. Headache children with temporomandibular disorders have several types of pain and other symptoms. Cephalalgia. 2005;25(11):1054–60.
Lindstedt F, Berrebi J, Greayer E, Lonsdorf TB, Schalling M, Ingvar M, Kosek E. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. PLoS One. 2011;6(3):e18252.
Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. Cutaneous allodynia in the migraine population. Ann Neurol. 2008;63(2):148–58.
Lovati C, Giani L, Castoldi D, Mariotti D’Alessandro C, DeAngeli F, Capiluppi E, D’Amico D, Mariani C. Osmophobia in allodynic migraineurs: cause or consequence of central sensitization? Neurol Sci. 2015;36 Suppl 1:145–7.
Lukacs M, Haanes KA, Majlath Z, Tajti J, Vecsei L, Warfvinge K, Edvinsson L. Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion. J Headache Pain. 2015;16:564.
Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain. 1995;63(3):341–51.
Marklund S, Wiesinger B, Wanman A. Reciprocal influence on the incidence of symptoms in trigeminally and spinally innervated areas. Eur J Pain. 2010;14(4):366–71.
Melo CE, Oliveira JL, Jesus AC, Maia ML, de Santana JC, Andrade LS, Quintans JD, Quintans-Junior LJ, Conti PC, Bonjardim LR. Temporomandibular disorders dysfunction in headache patients. Med Oral Patol Oral Cir Bucal. 2012;17(6):e1042–6.
Mense S. Muscle pain: mechanisms and clinical significance. Dtsch Arztebl Int. 2008;105(12):214–9.
Mense S. Algesic agents exciting muscle nociceptors. Exp Brain Res. 2009;196(1):89–100.
Michelotti A, Liguori R, Toriello M, D’Anto V, Vitale D, Castaldo G, Sacchetti L. Catechol-O-methyltransferase (COMT) gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy. Clin J Pain. 2014;30(2):129–33.
Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128(3):199–208.
Nahman-Averbuch H, Granovsky Y, Coghill RC, Yarnitsky D, Sprecher E, Weissman-Fogel I. Waning of “conditioned pain modulation”: a novel expression of subtle pronociception in migraine. Headache. 2013;53(7):1104–15.
Nilsson IM, List T, Drangsholt M. Headache and co-morbid pains associated with TMD pain in adolescents. J Dent Res. 2013;92(9):802–7.
Ojima K, Watanabe N, Narita N, Narita M. Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. BioPsychoSocial Med. 2007;1:3.
Olesen J, Steiner T, Bousser MG, Diener HC, Dodick D, First MB, Goadsby PJ, Gobel H, Lainez MJ, Lipton RB, Nappi G, Sakai F, Schoenen J, Silberstein SD. Proposals for new standardized general diagnostic criteria for the secondary headaches. Cephalalgia. 2009;29(12):1331–6.
Oono Y, Wang K, Baad-Hansen L, Futarmal S, Kohase H, Svensson P, Arendt-Nielsen L. Conditioned pain modulation in temporomandibular disorders (TMD) pain patients. Exp Brain Res. 2014;232(10):3111–9.
Park JW, Chung JW. Inflammatory cytokines and sleep disturbance in patients with temporomandibular disorders. J Oral Facial Pain Headache. 2016;30(1):27–33.
Peck CC, Goulet JP, Lobbezoo F, Schiffman EL, Alstergren P, Anderson GC, de Leeuw R, Jensen R, Michelotti A, Ohrbach R, Petersson A, List T. Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders. J Oral Rehabil. 2014;41(1):2–23.
Pfau DB, Rolke R, Nickel R, Treede RD, Daublaender M. Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome. Pain. 2009;147(1–3):72–83.
Pielsticker A, Haag G, Zaudig M, Lautenbacher S. Impairment of pain inhibition in chronic tension-type headache. Pain. 2005;118(1–2):215–23.
Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends Neurosci. 2002;25(6):319–25.
Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, Grignon S, Marchand S. DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain Off J Am Pain Soc. 2009;10(9):969–75.
Rainero I, Fasano E, Rubino E, Rivoiro C, Valfre W, Gallone S, Savi L, Gentile S, Lo Giudice R, De Martino P, Dall’Omo AM, Pinessi L. Association between migraine and HLA-DRB1 gene polymorphisms. J Headache Pain. 2005;6(4):185–7.
Reid KI, Gracely RH, Dubner RA. The influence of time, facial side, and location on pain-pressure thresholds in chronic myogenous temporomandibular disorder. J Orofac Pain. 1994;8(3):258–65.
Romero-Reyes M, Akerman S, Nguyen E, Vijjeswarapu A, Hom B, Dong HW, Charles AC. Spontaneous behavioral responses in the orofacial region: a model of trigeminal pain in mouse. Headache. 2013;53(1):137–51.
Russell MB, Saltyte-Benth J, Levi N. Are infrequent episodic, frequent episodic and chronic tension-type headache inherited? A population-based study of 11 199 twin pairs. J Headache Pain. 2006;7(3):119–26.
Sales Pinto LM, de Carvalho JJ, Cunha CO, Dos Santos Silva R, Fiamengui-Filho JF, Rodrigues Conti PC. Influence of myofascial pain on the pressure pain threshold of masticatory muscles in women with migraine. Clin J Pain. 2013;29(4):362–5.
Sandrini G, Rossi P, Milanov I, Serrao M, Cecchini AP, Nappi G. Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients. Cephalalgia. 2006;26(7):782–9.
Sarlani E, Grace EG, Reynolds MA, Greenspan JD. Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. Pain. 2004;109(1–2):115–23.
Sato H, Saisu H, Muraoka W, Nakagawa T, Svensson P, Wajima K. Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorder. J Orofac Pain. 2012;26(4):288–95.
Schiffman E, Ohrbach R, List T, Anderson G, Jensen R, John MT, Nixdorf D, Goulet JP, Kang W, Truelove E, Clavel A, Fricton J, Look J. Diagnostic criteria for headache attributed to temporomandibular disorders. Cephalalgia. 2012;32(9):683–92.
Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger. J Oral Facial Pain Headache. 2014;28(1):6–27.
Schmidt-Hansen PT, Svensson P, Bendtsen L, Graven-Nielsen T, Bach FW. Increased muscle pain sensitivity in patients with tension-type headache. Pain. 2007;129(1–2):113–21.
Sessle BJ. Peripheral and central mechanisms of orofacial inflammatory pain. Int Rev Neurobiol. 2011;97:179–206.
Shah JP, Danoff JV, Desai MJ, Parikh S, Nakamura LY, Phillips TM, Gerber LH. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil. 2008;89(1):16–23.
Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, Rhodes J, Medvedev A, Makarov S, Maixner W, Nackley AG. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness. Pain. 2011;152(12):2802–12.
Slade GD, Sanders AE, Bair E, Brownstein N, Dampier D, Knott C, Fillingim R, Maixner WO, Smith S, Greenspan J, Dubner R, Ohrbach R. Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study. Pain. 2013;154(5):750–60.
Slade GD, Sanders AE, Ohrbach R, Fillingim RB, Dubner R, Gracely RH, Bair E, Maixner W, Greenspan JD. Pressure pain thresholds fluctuate with, but do not usefully predict, the clinical course of painful temporomandibular disorder. Pain. 2014;155(10):2134–43.
Smith SB, Mir E, Bair E, Slade GD, Dubner R, Fillingim RB, Greenspan JD, Ohrbach R, Knott C, Weir B, Maixner W, Diatchenko L. Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. J Pain Offic J Am Pain Soc. 2013;14(12 Suppl):T91–101.e101–3.
Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother. 2012;12(5):577–85.
Suzuki R, Rygh LJ, Dickenson AH. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci. 2004;25(12):613–7.
Svensson P, Arendt-Nielsen L, Nielsen H, Larsen JK. Effect of chronic and experimental jaw muscle pain on pain-pressure thresholds and stimulus–response curves. J Orofac Pain. 1995;9(4):347–56.
Svensson P, Cairns BE, Wang K, Arendt-Nielsen L. Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain. 2003;104(1–2):241–7.
Svensson P, Castrillon E, Cairns BE. Nerve growth factor-evoked masseter muscle sensitization and perturbation of jaw motor function in healthy women. J Orofac Pain. 2008;22(4):340–8.
Svensson P, List T, Hector G. Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders. Pain. 2001;92(3):399–409.
Takahashi T, Kondoh T, Fukuda M, Yamazaki Y, Toyosaki T, Suzuki R. Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(2):135–41.
Takeuchi Y, Zeredo JL, Fujiyama R, Amagasa T, Toda K. Effects of experimentally induced inflammation on temporomandibular joint nociceptors in rats. Neurosci Lett. 2004;354(2):172–4.
Tchivileva IE, Lim PF, Smith SB, Slade GD, Diatchenko L, McLean SA, Maixner W. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics. 2010;20(4):239–48.
Thomsen LL, Kirchmann M, Bjornsson A, Stefansson H, Jensen RM, Fasquel AC, Petursson H, Stefansson M, Frigge ML, Kong A, Gulcher J, Stefansson K, Olesen J. The genetic spectrum of a population-based sample of familial hemiplegic migraine. Brain J Neurol. 2007;130(Pt 2):346–56.
Turp JC, Kowalski CJ, O’Leary N, Stohler CS. Pain maps from facial pain patients indicate a broad pain geography. J Dent Res. 1998;77(6):1465–72.
Vierck CJ, Wong F, King CD, Mauderli AP, Schmidt S, Riley 3rd JL. Characteristics of sensitization associated with chronic pain conditions. Clin J Pain. 2014;30(2):119–28.
Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A. Frequency of migraine headaches in patients with fibromyalgia. Headache. 2015;55(6):860–5.
Villa G, Ceruti S, Zanardelli M, Magni G, Jasmin L, Ohara PT, Abbracchio MP. Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. Mol Pain. 2010;6:89.
Wang K, Arendt-Nielsen L, Jensen T, Svensson P. Reduction of clinical temporomandibular joint pain is associated with a reduction of the jaw-stretch reflex. J Orofac Pain. 2004;18(1):33–40.
Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–15.
Wright EF, Clark EG, Paunovich ED, Hart RG. Headache improvement through TMD stabilization appliance and self-management therapies. Cranio J Craniomandib Pract. 2006;24(2):104–11.
Xanthos DN, Sandkuhler J. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat Rev Neurosci. 2014;15(1):43–53.
Yarnitsky D. Role of endogenous pain modulation in chronic pain mechanisms and treatment. Pain. 2015;156 Suppl 1:S24–31.
Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010;14(4):339.
You HJ, Lei J, Sui MY, Huang L, Tan YX, Tjolsen A, Arendt-Nielsen L. Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception. J Physiol. 2010;588(Pt 21):4177–88.
Yunus MB. Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arthritis Rheum. 2008;37(6):339–52.
Zhao YJ, Liu Y, Zhao YH, Li Q, Zhang M, Chen YJ. Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats. Neurosci Lett. 2015;602:150–5.
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Exposto, F., Svensson, P., Arendt-Nielsen, L. (2017). Temporomandibular Disorder Comorbidity. In: Giamberardino, M., Martelletti, P. (eds) Comorbidities in Headache Disorders. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-41454-6_9
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