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Toxicological Aspects of Polymer Nanoparticles

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Polymer Nanoparticles for Nanomedicines

Abstract

This chapter describes the effects of some physico-chemical properties of polymer nanoparticles influencing the development of toxicological effects. More particularly, the effect of some parameters that may control the interaction of polymer nanoparticles with the biological environment (such as their composition, size, surface properties, and biodegradability) and, thus, be key factors of their efficacy and toxicity, is discussed. In addition, the chapter also reviews the toxicity results that have been found in the literature regarding the administration of polymer nanoparticles as delivery systems by different ways of administration including intravenous, oral, pulmonary, nasal, and ophthalmic routes.

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Acknowledgments

The authors wish to thank for support by the European Community´s Seventh Framework Programme via the large project “Alexander” (FP7-2011-NMP-280761).

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Authors and Affiliations

  1. Department of Pharmacy and Pharmaceutical Technology, University of Navarra, C/Irunlarra, 1, 31080, Pamplona, Spain

    Juan M. Irache, Nekane Martín-Arbella & Patricia Ojer

  2. Department of Pharmacology and Toxicology, University of Navarra, 31080, Pamplona, Spain

    Patricia Ojer, Amaya Azqueta & Adela Lopez de Cerain

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  1. Juan M. Irache
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  2. Nekane Martín-Arbella
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  3. Patricia Ojer
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  4. Amaya Azqueta
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Correspondence to Juan M. Irache .

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  1. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Christine Vauthier

  2. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Gilles Ponchel

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Irache, J.M., Martín-Arbella, N., Ojer, P., Azqueta, A., Lopez de Cerain, A. (2016). Toxicological Aspects of Polymer Nanoparticles. In: Vauthier, C., Ponchel, G. (eds) Polymer Nanoparticles for Nanomedicines. Springer, Cham. https://doi.org/10.1007/978-3-319-41421-8_16

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