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Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity

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Abstract

Nanoparticles are increasingly used in biomedical applications as active pharmaceutical ingredients, drug carriers, or medical devices. Nanoparticles interaction with plasma proteins may influence their biodistribution by promoting interaction with and uptake by the circulating and tissue resident phagocytes. Biodistribution to off intended target-sites may lead to decrease in therapeutic efficacy and result in undesirable toxicities. Therefore understanding nanoparticle physicochemical properties, which determine protein binding, and consequences of protein corona on nanoparticle biodistribution and toxicity are important elements of the preclinical development of nanomedicines and nanoparticle-based medical devices. The focus of this chapter is to discuss the most recent data on nanoparticle interactions with blood components and how particle size and surface charge define their compatibility with the immune system.

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Acknowledgments

This project has been funded in whole or in part with Federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government.

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  1. Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA

    Anna N. Ilinskaya & Marina A. Dobrovolskaia

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  1. Anna N. Ilinskaya
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  2. Marina A. Dobrovolskaia
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Correspondence to Marina A. Dobrovolskaia .

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  1. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Christine Vauthier

  2. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Gilles Ponchel

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Ilinskaya, A.N., Dobrovolskaia, M.A. (2016). Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity. In: Vauthier, C., Ponchel, G. (eds) Polymer Nanoparticles for Nanomedicines. Springer, Cham. https://doi.org/10.1007/978-3-319-41421-8_15

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