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Genomics Study of Gastric Cancer and Its Molecular Subtypes

  • Siu Tsan Yuen
  • Suet Yi LeungEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 908)

Abstract

Gastric cancer is a heterogeneous disease encompassing diverse morphological (intestinal versus diffuse) and molecular subtypes (MSI, EBV, TP53 mutation). Recent advances in genomic technology have led to an improved understanding of the driver gene mutational profile, gene expression, and epigenetic alterations that underlie each of the subgroups, with therapeutic implications in some of these alterations. There have been attempts to classify gastric cancers based on these genomic features, with an aim to improve prognostication and predict responsiveness to specific drug therapy. The eventual aims of these genomic studies are to develop deep biological insights into the carcinogenic pathway in each of these subtypes. Future large-scale drug screening strategies may then be able to link these genomic features to drug responsiveness, eventually leading to genome-guided personalized medicine with improved cure rates.

Keywords

Gastric adenocarcinoma Next-generation sequencing Whole-genome sequencing Whole-exome sequencing Gene expression profiling DNA copy number profiling Methylation profiling miRNA profiling Integrative genomics analysis Microsatellite instability Epstein-Barr virus 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of PathologyQueen Mary Hospital, The University of Hong KongPok Fu LamHong Kong

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