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Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract pp 393–408Cite as

Helicobacter pylori, Cancer, and the Gastric Microbiota

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 908))

Abstract

Gastric adenocarcinoma is one of the leading causes of cancer-related death worldwide and Helicobacter pylori infection is the strongest known risk factor for this disease. Although the stomach was once thought to be a sterile environment, it is now known to house many bacterial species leading to a complex interplay between H. pylori and other residents of the gastric microbiota. In addition to the role of H. pylori virulence factors, host genetic polymorphisms, and diet, it is now becoming clear that components of the gastrointestinal microbiota may also influence H. pylori-induced pathogenesis. In this chapter, we discuss emerging data regarding the gastric microbiota in humans and animal models and alterations that occur to the composition of the gastric microbiota in the presence of H. pylori infection that may augment the risk of developing gastric cancer.

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The authors declare there are no conflicts of interest.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

    Lydia E. Wroblewski & Richard M. Peek Jr.

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  1. Lydia E. Wroblewski
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  2. Richard M. Peek Jr.
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Correspondence to Richard M. Peek Jr. .

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Editors and Affiliations

  1. UCL Cancer Institute, University College London, London, United Kingdom

    Marnix Jansen

  2. Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom

    Nicholas A. Wright

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Wroblewski, L.E., Peek, R.M. (2016). Helicobacter pylori, Cancer, and the Gastric Microbiota. In: Jansen, M., Wright, N. (eds) Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract. Advances in Experimental Medicine and Biology, vol 908. Springer, Cham. https://doi.org/10.1007/978-3-319-41388-4_19

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