The Japanese Viewpoint on the Histopathology of Early Gastric Cancer

  • Shigeki SekineEmail author
  • Hiroshi Yoshida
  • Marnix Jansen
  • Ryoji Kushima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 908)


Japanese histopathologists have traditionally had greater opportunity to study the histology and clinical course of early gastric cancer because of technological developments including double contrast radiography and endoscopy systems, combined with the higher incidence of gastric cancer in the general population in Japan. Endoscopic resection is now considered best practice for treatment of early gastric cancers with a negligible risk of lymph node metastasis. Histopathologic evaluation plays a critical role in assessing the likelihood of lymph node metastasis on endoscopically resected specimens. There remains disparity between Western and Japanese histopathologists in the conceptual approach to the histopathologic evaluation of neoplastic lesions in the upper gastrointestinal tract, in particular regarding lesions straddling the borderline between noninvasive and invasive disease. Although in routine practice, the clinical impact of these conceptual differences is small, this disparity does complicate international exchange of datasets and the development of globally applicable formal definitions. Here we review the current practice in histological diagnosis of early gastric cancer in Japan and discuss some of the conceptual differences between Japanese and Western histopathological assessment of lesions in the neoplastic stomach.


Gastric cancer Endoscopy Histopathology EBV Helicobacter pylori 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Shigeki Sekine
    • 1
    Email author
  • Hiroshi Yoshida
    • 1
  • Marnix Jansen
    • 2
  • Ryoji Kushima
    • 3
  1. 1.Pathology Division, National Cancer Center HospitalTokyoJapan
  2. 2.UCL Cancer InstituteUniversity College LondonLondonUK
  3. 3.Department of Clinical Laboratory Medicine and Diagnostic PathologyShiga University of Medical ScienceOtsuJapan

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