Endoluminal Diagnosis of Early Gastric Cancer and Its Precursors: Bridging the Gap Between Endoscopy and Pathology

  • Noriya UedoEmail author
  • Kenshi Yao
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 908)


Although dye-based and image-enhanced endoscopic techniques have revolutionized endoscopic diagnosis, conventional white light endoscopy still plays an important role in the diagnosis of early gastric cancer (EGC) during routine endoscopy. Chromoendoscopy reveals morphological characteristics of the mucosal lesions by enhancing mucosal contrast, while narrow-band imaging (NBI) facilitates detailed evaluation of the vascular architecture and surface features. Positive diagnostic findings of EGC on white light imaging and indigo carmine chromoendoscopy are a sharply demarcated lesion and irregularity in surface morphology or color. Magnifying NBI further improves diagnostic accuracy of white light imaging and chromoendoscopy. We review our approach to the endoscopic diagnosis of (pre-)malignant lesions in the stomach and discuss in detail novel endoscopic microvascular architectural patterns which further leverage diagnostic biopsy yield. We expect that further improvement of endoscopic techniques and correlative studies will close the gap between endoscopy and pathology.


Gastric cancer Early gastric cancer Chromoendoscopy Narrow band imaging Magnification endoscopy Helicobacter pylori Chronic atrophic gastritis Intestinal metaplasia 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Gastrointestinal OncologyOsaka Medical Center for Cancer and Cardiovascular DiseaseOsakaJapan
  2. 2.Department of EndoscopyFukuoka University Chikushi HospitalChikushino, FukuokaJapan

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