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Experimental Electromechanics of Red Blood Cells Using Dielectrophoresis-Based Microfluidics

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Mechanics of Biological Systems and Materials, Volume 6

Abstract

This study focuses on electrically coupled mechanics of red blood cells (RBCs) using dielectrophoresis in a microfluidic chamber. When RBCs are exposed to non-uniform alternating current electric fields, they exhibit not only a net motion towards high electric field gradients but also morphological deformation at certain conditions. Through interdigitated electrode arrays, multiple cells can be trapped and stretched simultaneously in response to dielectrophoresis actuations. We utilize this approach to measure mechanical properties of individual RBCs. In addition, this dielectrophoresis platform provides a flexibility in different loading profiles, allowing us to measure both static and dynamic behavior of individual RBCs in response to cyclic stretching-relaxation loading. This approach can potentially lead to insights of the accumulative membrane failure of RBCs in blood and extracorporeal circulations.

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Authors and Affiliations

  1. Department of Ocean and Mechanical Engineering, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Yuhao Qiang, Jia Liu, Michael Mian & E. Du

Authors
  1. Yuhao Qiang
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  2. Jia Liu
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  3. Michael Mian
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  4. E. Du
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Corresponding author

Correspondence to E. Du .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, State University of New York at Stony Brook, Stony Brook, New York, USA

    Chad S. Korach

  2. Michigan State University , East Lansing, Michigan, USA

    Srinivasan Arjun Tekalur

  3. Purdue University, West Lafayette, Indiana, USA

    Pablo Zavattieri

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Qiang, Y., Liu, J., Mian, M., Du, E. (2017). Experimental Electromechanics of Red Blood Cells Using Dielectrophoresis-Based Microfluidics. In: Korach, C., Tekalur, S., Zavattieri, P. (eds) Mechanics of Biological Systems and Materials, Volume 6. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, Cham. https://doi.org/10.1007/978-3-319-41351-8_18

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  • DOI: https://doi.org/10.1007/978-3-319-41351-8_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-41350-1

  • Online ISBN: 978-3-319-41351-8

  • eBook Packages: EngineeringEngineering (R0)

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