Abstract
Measurements of human Tympanic Membrane (TM, eardrum) motions require nanometer and microsecond spatio-temporal resolutions while maintaining a field-of-view of about one centimeter. Previously, we have developed holographic methods to successfully measuring continuous and transient responses of post-mortem TM’s. To expand our capabilities to in-vivo measurements, it is necessary to overcome such challenges as the influence of submillimeter physiological motions as well as the confined location of the TM. We are developing novel High-speed Digital Holographic Methods (HDHM) in combination with recently developed image and data processing algorithms to overcome such challenges. Our developments have unique capabilities that utilize the full spatio-temporal resolution of high-speed cameras (i.e., >147,000 points at >42,000 fps) to measure nanometer-scale TM motions in the audible range (0.02–20 kHz). We present preliminary holographic measurements made on an anesthetized chinchilla in a controlled anechoic chamber in-vivo and in-vitro. To the best of our knowledge, these data are reported for the first time and establish the potential of HDHM as a hearing research and clinical tool to further expand our understanding of the human hearing processes.
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Acknowledgements
This work has been funded by the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Health (NIH), the Massachusetts Eye and Ear Infirmary (MEEI), NSF MRI program award: CMMI-1428921, and the Mittal Fund. The authors would like to acknowledge contributions of Nima Maftoon, Melissa McKinnon, and Michael E. Ravicz from the MEEI and Ivo Dobrev and Koohyar Pooladvand from the CHSLT at the Worcester Polytechnic Institute.
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Razavi, P., Cheng, J.T., Furlong, C., Rosowski, J.J. (2017). High-Speed Holography for In-Vivo Measurement of Acoustically Induced Motions of Mammalian Tympanic Membrane. In: Korach, C., Tekalur, S., Zavattieri, P. (eds) Mechanics of Biological Systems and Materials, Volume 6. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, Cham. https://doi.org/10.1007/978-3-319-41351-8_11
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DOI: https://doi.org/10.1007/978-3-319-41351-8_11
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