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Three-dimensional Genomic Organization of Genes’ Function in Eukaryotes

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Evolutionary Biology

Abstract

It is well known that in prokaryotes, genes are organized in transcription units called operons. Since each operon includes genes which are related to the same pathway, a relation between genomic proximity and functionality can be easily observed. In eukaryotes, usually there are no operons; however, in the last few decades, there have been growing evidence that the organization of eukaryotic genes is not random: Evolution shapes gene organization in eukaryotes in a way that will improve the organism’s fitness. In this chapter, we will review how previous studies in the field employed sophisticated experiments and analysis tools to decipher the way genes are organized in eukaryotic genomes.

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Acknowledgments

AD is grateful to the Azrieli Foundation for the award of an Azrieli Fellowship. This study was supported in part by a fellowship from the Edmond J. Safra Center for Bioinformatics at Tel Aviv University.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Tel Aviv University (TAU), Tel Aviv, Israel

    Alon Diament & Tamir Tuller

  2. The Sagol School of Neuroscience, Tel-Aviv University (TAU), Tel-Aviv, Israel

    Tamir Tuller

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  1. Alon Diament
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  2. Tamir Tuller
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Correspondence to Tamir Tuller .

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  1. CNRS, Laboratoire Evolution Biologique et Modélisation, Université d’Aix-Marseille, Marseille, France

    Pierre Pontarotti

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Diament, A., Tuller, T. (2016). Three-dimensional Genomic Organization of Genes’ Function in Eukaryotes. In: Pontarotti, P. (eds) Evolutionary Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-41324-2_14

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