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Senescence

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Melanoma Development

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Abstract

Cellular senescence is a programme initiated by many stress signals including aberrant activation of oncogenes, DNA damage, oxidative lesions, and telomere attrition. Once engaged, senescence irreversibly limits cellular proliferation and can alter metabolism and suppress tumour formation in vivo. The precise mechanisms driving senescence are still not precisely defined, although the p53-DNA damage response and pRb tumour suppressor pathways are critical effectors. Senescent cells also develop aberrant gene expression profiles and acquire pro-inflammatory behaviour that may contribute to organismal aging and age-related diseases, including cancer. It is not yet clear whether the detrimental properties of senescent cells can be minimised in vivo, but the therapeutic potential of this stress-induced programme may depend on establishing a new equilibrium that favours tumour suppressor activity.

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Acknowledgements

Our work is supported by the National Health and Medical Research Council of Australia (NHMRC), the Cancer Council of New South Wales. HR is a NHMRC Research Fellow.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Macquarie University, Sydney, NSW, 2109, Australia

    Helen Rizos

  2. Department of Dermatology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, D-93053, Regensburg, Germany

    Sebastian Haferkamp

  3. Department of Medicine, Westmead Institute, University of Sydney, Westmead, NSW, 2145, Australia

    Lyndee L. Scurr

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  1. Helen Rizos
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  2. Sebastian Haferkamp
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  3. Lyndee L. Scurr
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Correspondence to Helen Rizos .

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  1. Institute for Biochemistry, Erlangen, Germany

    Anja K. Bosserhoff

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Rizos, H., Haferkamp, S., Scurr, L.L. (2017). Senescence. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Cham. https://doi.org/10.1007/978-3-319-41319-8_11

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