Abstract
Inorganic polyphosphate (polyP) is a polymer molecule of variable chain length, formed of linearly arranged orthophosphate residues that are linked through high-energy phosphoanhydride bonds identical to the ones found in ATP. PolyP has also been found in mammalian cells – it is important for blood coagulation, osteoclast function, immune response, etc. In the brain polyP is essential for precise functioning of mitochondria – from significance for the energy metabolism and mitochondrial calcium handling to the activation of permeability transition pore (PTP). PolyP has been shown to be a gliotransmitter, enabling signaling between astrocytes via activation of P2Y1 receptors. Thus, polyP plays many important roles in mammalian brain cells, ranging from signal transduction, mitochondrial metabolism, and activation of ion channels to involvement in PTP opening and triggering of cell death.
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Baev, A.Y., Angelova, P.R., Abramov, A.Y. (2016). Role of Inorganic Polyphosphate in the Cells of the Mammalian Brain. In: Kulakovskaya, T., Pavlov, E., Dedkova, E. (eds) Inorganic Polyphosphates in Eukaryotic Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-41073-9_8
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DOI: https://doi.org/10.1007/978-3-319-41073-9_8
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