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Topological Interactions in Ring Polymers pp 79–94Cite as

A Bio-Physical Model for the Kinetoplast DNA

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Part of the book series: Springer Theses ((Springer Theses))

Abstract

The Kinetoplast DNA (or KDNA) (Simpson 1967) is one of the most complex and singular forms of DNA in nature. It is uniquely found in the mitochondrion of a group of unicellular eukaryotic organisms of the class Kinetoplastida. Some of these organisms have been studied since the late ’60s because they are responsible for several serious diseases such as sleeping sickness and leishmaniasis (Young and Morales 1987), and are among the earliest diverging eukaryotic organisms containing a mitochondrion (Avliyakulov et al. 2004).

Sometimes careful physics-based thinking can illuminate complicated issues in biology

M.E. Cates

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Notes

  1. 1.

    This could be argued to be too sensitive to the presence of topo II, and some threshold could be added to regulate the sensitivity of \(S(t=0)\) to the value \(\phi _T\). In order to keep things simple I decided to neglect this correction.

  2. 2.

    In a time T, \(N_0\) initial cells duplicate \(T/T_R=m\) times, i.e. \(N_m = N_0\exp {(m\log {(2)})}\).

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  1. School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK

    Davide Michieletto

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  1. Davide Michieletto
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Michieletto, D. (2016). A Bio-Physical Model for the Kinetoplast DNA. In: Topological Interactions in Ring Polymers. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-41042-5_5

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