Abstract
A computer simulation was carried out for thrombus formation under the influence of blood flow after Fontan operation. Blood was modeled by computed particles assigned as normal blood or thrombus. Blood flow was calculated using a moving particle semi-implicit method. In a model of blood coagulation that causes thrombi, a normal blood particle changed to a thrombus when its shear rate was lower than a threshold. A spring force was employed to express the coagulation, and was substituted into the NS equations as the external force to couple the coagulation and the blood flow. In simulations, thrombus formation was affected by blood flow behaviors, such as stagnation and recirculation. The atrio-pulmonary connection (APC) square model showed the highest incidence for thrombus formation in the right atrium due to flow stagnation, followed by the APC round, whereas no thrombus was formed in the total cavopulmonary connection model. This result suggests that local hemodynamic behavior associated with the complex channel geometry plays a major role in thrombus formation in the Fontan route.
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Acknowledgements
This research was partly funded by Grants-in-Aid for Scientific Research (15H03915 and 25630046), JSPS. KT was supported by MEXT SPIRE Supercomputational Life Science. KS was supported by the Inohana Alumni Association of the Chiba University of Medicine (12046).
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Tsubota, Ki., Sughimoto, K., Okauchi, K., Liu, H. (2016). Particle Method Simulation of Thrombus Formation in Fontan Route. In: Bazilevs, Y., Takizawa, K. (eds) Advances in Computational Fluid-Structure Interaction and Flow Simulation. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-40827-9_30
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DOI: https://doi.org/10.1007/978-3-319-40827-9_30
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