NG2-glia, More Than Progenitor Cells

  • Jaime Eugenín-von BernhardiEmail author
  • Leda DimouEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 949)


NG2-glia are a mysterious and ubiquitous glial population with a highly branched morphology. Initial studies suggested that their unique function is the generation and maintenance of oligodendrocytes in the central nervous system (CNS), important for proper myelination and therefore for axonal support and fast conduction velocity. Over the last years this simplistic notion has been dramatically changed: the wide and homogeneous distribution of NG2-glia within all areas of the developing CNS that is maintained during the whole lifespan, their potential to also differentiate into other cell types in a spatiotemporal manner, their active capability of maintaining their population and their dynamic behavior in altered conditions have raised the question: are NG2-glia simple progenitor cells or do they play further major roles in the normal function of the CNS? In this chapter, we will discuss some important features of NG2-glia like their homeostatic distribution in the CNS and their potential to differentiate into diverse cell types. Additionally, we will give some further insights into the properties that these cells have, like the ability to form synapses with neurons and their plastic behavior triggered by neuronal activity, suggesting that they may play a role specifically in myelin and more generally in brain plasticity. Finally, we will briefly review their behavior in disease models suggesting that their function is extended to repair the brain after insult.


NG2-glia Myelination Oligodendrocytes Neuronal activity NG2-glia neuronal synapse Disease Injury Proliferation Differentiation Plasticity 


Amyloid protein β


Alzheimer’s disease


α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid


AMPA receptor


Achaete-scute homolog 1


Α-scorpion toxin




Voltage-gated calcium channels


Adenomatous polyposis coli


Central nervous system




Experimental autoimmune encephalomyelitis




Excitatory postsynaptic current


γ-aminobutyric acid receptor


G-protein coupled receptor 17


Voltage-gated potassium channels




Mammalian achaete-scute homolog 1


Myelin basic protein


Middle cerebral artery occlusion


Miniature EPSC


Multiple sclerosis


Voltage-gated sodium channels




Neuron/glia antigen 2


N-methyl-d-aspartate receptor


Oligodendrocyte progenitor cells


Platelet-derived growth factor


PDGF receptor α


Prefrontral cortex


Proteolipid protein


Peripheral nervous system


Postsynaptic density protein 95


Tetanus neurotoxin




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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Physiological Genomics, Biomedical CenterLudwig-Maximilians-UniversityPlanegg-MartinsriedGermany
  2. 2.Graduate School of Systemic NeuroscienceLudwig-Maximilians-UniversityPlanegg-MartinsriedGermany

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