Abstract
Variceal bleeding is a fatal complication of portal hypertension, which can be secondary to cirrhosis or various disorders that lead to increased portal pressures in a patient with preserved hepatic function. Current guideline recommendations base prophylaxis on the size of the varices and their likelihood of bleeding based on their endoscopic appearance and the severity of liver disease. Non-selective beta blockers are the mainstay of medical primary prophylaxis. In active variceal bleeding, medications are given to decrease portal pressures and endoscopy is performed with variceal band ligation to stop bleeding. For secondary prophylaxis, a combination of beta blockers and variceal band ligation is used to prevent re-bleeding. If acute variceal bleeding treated by endoscopy with band ligation fails to control bleeding, interventional radiology can be performed for a transjugular intrahepatic portosystemic shunt procedure or a surgical consultation should be called for evaluation for portacaval shunting to decompress the portal system.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Garcia-Tsao G, Sanyal A, Grace N, Carey W, Shuhart M, Davis G, et al. AASLD practice guidelines: prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46(3):922–38.
Garcia-Tsao G, Bosch J, Groszmann R. Portal hypertension and variceal bleeding-unresolved issues. Summary of an American Association for the Study of Liver Diseases and European Association for the Study of the Liver single-topic conference. Hepatology. 2008;47(5):1764–72.
Khanna R, Sarin S. Non-cirrhotic portal hypertension-diagnosis and management. J Hepatol. 2014;60(2):421–41.
Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010;362(9):823–32.
Iwakri Y. Pathophysiology of portal hypertension. Clin Liver Dis. 2014;18(2):281–91.
Kumar A, Sharma P, Sarin S. Hepatic venous pressure gradient measurement: time to learn! Indian J Gastroenterol. 2008;27:74–80.
Garcia-Pagan J, Patch D. Trials and tribulations: the prevention of variceal bleeding. Gastroenterology. 2015;149(3):528–31.
The North Italian Endoscopic Club for the Study and Treatment of Liver Diseases. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med. 1988;319(15):983–9.
Garcia-Pagan J, Excorsell A, Moitinho E, Bosch J. Influence of pharmacological agents on portal hemodynamics: basis for its use in the treatment of portal hypertension. Semin Liver Dis. 1999;19(4):427–38.
Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroghs A, Planas R, et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005;353(21):2254–61.
Merkel C, Marin R, Angeli P, Zanella P, Felder M, Bernardinello E, et al. A placebo-controlled trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology. 2004;127(2):476–84.
Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W, et al. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology. 2004;40(1):65–72.
Conn H. Prophylactic portacaval shunts. Ann Intern Med. 1969;70(4):859–64.
Lindor K, Gershwin E, Poupon R, Kaplan M, Bergasa N, Healthcote E, et al. AASLD practice guidelines: primary biliary cirrhosis. Hepatology. 2009;50(1):291–308.
Angulo P, Lindor K, Thenaau T, Jorgensen RA, Malinchoc M, Kamath P, et al. Utilization of the Mayo risk score in patients with primary biliary cirrhosis receiving ursodeoxycholic acid. Liver. 1999;19(2):115–21.
Hwang JH, Shergill A, Acosta R, Chandrasekhara V, Chathadi K, Decker G, et al. The role of endoscopy in the management of variceal hemorrhage. Gastrointest Endosc. 2014;80(2):221–7.
Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for upper GI bleeding. N Engl J Med. 2013;368(1):11–21.
de Frachis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762–8.
Castaneda B, Morales J, Lionetti R, Moitinho E, Andreu V, Perez-Del-Pulgar S, et al. Effects of blood volume restitution following portal hypertensive related bleeding in anesthetized cirrhotic rats. Hepatology. 2001;33(4):821–5.
Chavez-Tapia N, Barrientos-Gutierrez T, Tellez-Avila F, Soares-Weiser K, Uribe M. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010;(9) CD002907.
Fernandez J, Ruiz del Arbol L, Gomez C, Durandez R, Serradilla R, Guarner C, et al. Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology. 2006;131(4):1049–56.
Lo G, Lai K, Chen J, Hwu J, Chang C, Chen S, et al. A prospective, randomized trial of sclerotherapy versus ligation in the management of bleeding esophageal varices. Hepatology. 1995;22(2):466–71.
Sarin S, Laroti D, Saxena S, Murthy N, Makwana U. Prevalence, classification, and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology. 1992;16(6):1343–9.
Costa G, Cruz Jr R, Abu-Elmagd K. Surgical shunt versus TIPS for treatment of variceal hemorrhage in the current era of liver and multivisceral transplantation. Surg Clin North Am. 2010;90(4):891–905.
Orloff M. Fifty-three years experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in cirrhosis. JAMA Surg. 2014;149(2):155–69.
Sabri S, Saad W. Balloon-occluded retrograde transvenous obliteration (BRTO): technique and intraprocedural imaging. Semin Intervent Radiol. 2011;28(3):303–13.
Mihas A, Sanyal A. Recurrent variceal bleeding despite endoscopic and medical therapy. Gastroenterology. 2004;127(2):621–9.
Ahn S, Park S, Tak W. Prospective validation of Baveno definitions and criteria for failure to control bleeding in portal hypertension. Hepatology. 2015;61(3):1033–40.
Feldman M, Friedman L, Brandt L. Sleisenger and Fordtran’s gastrointestinal and liver disease. 9th ed. Philadelphia: Saunders Elsevier; 2012.
Escorcell A, Pavel O, Cardenas A, Morillas R, Llop E, Villanueva C, et al. Esophageal balloon tamponade vs. esophageal stent in controlling acute refractory variceal bleeding: a multicenter RCT. Hepatology. 2015. doi:10.1002/hep.28360.
Fidelman N, Kwan S, LaBerge J, Gordon R. The transjugular intrahepatic portosystemic shunt: an update. AJR Am J Roentgenol. 2012;199(4):746–55.
Sanyal AJ, Freedman A, Luketic VA, Purdum PP, Shiffman M, Tisnado J, et al. Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy. Gastroenterology. 1996;111(1):138–46.
Garcia-Pagan J, Caca K, Bureau C, Laleman W. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362(25):2370–9.
Voros D, Polydorou A, Polmeneas G, Vassilou I, Melemeni A, Chondrogiannis K, et al. Long-term results with the modified Sugiura procedure for the management of variceal bleeding: standing the test of time in the treatment of bleeding esophageal varices. World J Surg. 2012;36(3):659–66.
Henderson J, Boyer T, Kutner M, Galloway J, Rikkers L, Jeffers L, et al. Distal splenorenal shunt versus transjubular intrahepatic portal systemic shunt for variceal bleeding: a randomized trial. Gastroenterology. 2006;130(6):1643–51.
Zhang H, Li W, Ye H, Xiao Z. Long term results of the paraesophagogastric devascularization with or without esophageal transection: which is more suitable for variceal bleeding? World J Surg. 2014;38(3):2105–12.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing AG
About this chapter
Cite this chapter
Tzimas, D., Bucobo, J.C., Telem, D. (2016). Management of Esophageal Variceal Bleeding. In: Pryor, A., Pappas, T., Branch, M. (eds) Gastrointestinal Bleeding. Springer, Cham. https://doi.org/10.1007/978-3-319-40646-6_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-40646-6_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40644-2
Online ISBN: 978-3-319-40646-6
eBook Packages: MedicineMedicine (R0)