Skip to main content

Management of Esophageal Variceal Bleeding

  • Chapter
  • First Online:
Gastrointestinal Bleeding

Abstract

Variceal bleeding is a fatal complication of portal hypertension, which can be secondary to cirrhosis or various disorders that lead to increased portal pressures in a patient with preserved hepatic function. Current guideline recommendations base prophylaxis on the size of the varices and their likelihood of bleeding based on their endoscopic appearance and the severity of liver disease. Non-selective beta blockers are the mainstay of medical primary prophylaxis. In active variceal bleeding, medications are given to decrease portal pressures and endoscopy is performed with variceal band ligation to stop bleeding. For secondary prophylaxis, a combination of beta blockers and variceal band ligation is used to prevent re-bleeding. If acute variceal bleeding treated by endoscopy with band ligation fails to control bleeding, interventional radiology can be performed for a transjugular intrahepatic portosystemic shunt procedure or a surgical consultation should be called for evaluation for portacaval shunting to decompress the portal system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Garcia-Tsao G, Sanyal A, Grace N, Carey W, Shuhart M, Davis G, et al. AASLD practice guidelines: prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46(3):922–38.

    Article  CAS  PubMed  Google Scholar 

  2. Garcia-Tsao G, Bosch J, Groszmann R. Portal hypertension and variceal bleeding-unresolved issues. Summary of an American Association for the Study of Liver Diseases and European Association for the Study of the Liver single-topic conference. Hepatology. 2008;47(5):1764–72.

    Article  PubMed  Google Scholar 

  3. Khanna R, Sarin S. Non-cirrhotic portal hypertension-diagnosis and management. J Hepatol. 2014;60(2):421–41.

    Article  PubMed  Google Scholar 

  4. Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010;362(9):823–32.

    Article  CAS  PubMed  Google Scholar 

  5. Iwakri Y. Pathophysiology of portal hypertension. Clin Liver Dis. 2014;18(2):281–91.

    Article  Google Scholar 

  6. Kumar A, Sharma P, Sarin S. Hepatic venous pressure gradient measurement: time to learn! Indian J Gastroenterol. 2008;27:74–80.

    PubMed  Google Scholar 

  7. Garcia-Pagan J, Patch D. Trials and tribulations: the prevention of variceal bleeding. Gastroenterology. 2015;149(3):528–31.

    Article  PubMed  Google Scholar 

  8. The North Italian Endoscopic Club for the Study and Treatment of Liver Diseases. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med. 1988;319(15):983–9.

    Article  Google Scholar 

  9. Garcia-Pagan J, Excorsell A, Moitinho E, Bosch J. Influence of pharmacological agents on portal hemodynamics: basis for its use in the treatment of portal hypertension. Semin Liver Dis. 1999;19(4):427–38.

    Article  CAS  PubMed  Google Scholar 

  10. Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroghs A, Planas R, et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005;353(21):2254–61.

    Article  CAS  PubMed  Google Scholar 

  11. Merkel C, Marin R, Angeli P, Zanella P, Felder M, Bernardinello E, et al. A placebo-controlled trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology. 2004;127(2):476–84.

    Article  CAS  PubMed  Google Scholar 

  12. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W, et al. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology. 2004;40(1):65–72.

    Article  PubMed  Google Scholar 

  13. Conn H. Prophylactic portacaval shunts. Ann Intern Med. 1969;70(4):859–64.

    Article  CAS  PubMed  Google Scholar 

  14. Lindor K, Gershwin E, Poupon R, Kaplan M, Bergasa N, Healthcote E, et al. AASLD practice guidelines: primary biliary cirrhosis. Hepatology. 2009;50(1):291–308.

    Article  PubMed  Google Scholar 

  15. Angulo P, Lindor K, Thenaau T, Jorgensen RA, Malinchoc M, Kamath P, et al. Utilization of the Mayo risk score in patients with primary biliary cirrhosis receiving ursodeoxycholic acid. Liver. 1999;19(2):115–21.

    Article  CAS  PubMed  Google Scholar 

  16. Hwang JH, Shergill A, Acosta R, Chandrasekhara V, Chathadi K, Decker G, et al. The role of endoscopy in the management of variceal hemorrhage. Gastrointest Endosc. 2014;80(2):221–7.

    Article  PubMed  Google Scholar 

  17. Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for upper GI bleeding. N Engl J Med. 2013;368(1):11–21.

    Article  CAS  PubMed  Google Scholar 

  18. de Frachis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762–8.

    Article  Google Scholar 

  19. Castaneda B, Morales J, Lionetti R, Moitinho E, Andreu V, Perez-Del-Pulgar S, et al. Effects of blood volume restitution following portal hypertensive related bleeding in anesthetized cirrhotic rats. Hepatology. 2001;33(4):821–5.

    Article  CAS  PubMed  Google Scholar 

  20. Chavez-Tapia N, Barrientos-Gutierrez T, Tellez-Avila F, Soares-Weiser K, Uribe M. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010;(9) CD002907.

    Google Scholar 

  21. Fernandez J, Ruiz del Arbol L, Gomez C, Durandez R, Serradilla R, Guarner C, et al. Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology. 2006;131(4):1049–56.

    Article  CAS  PubMed  Google Scholar 

  22. Lo G, Lai K, Chen J, Hwu J, Chang C, Chen S, et al. A prospective, randomized trial of sclerotherapy versus ligation in the management of bleeding esophageal varices. Hepatology. 1995;22(2):466–71.

    Article  CAS  PubMed  Google Scholar 

  23. Sarin S, Laroti D, Saxena S, Murthy N, Makwana U. Prevalence, classification, and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology. 1992;16(6):1343–9.

    Article  CAS  PubMed  Google Scholar 

  24. Costa G, Cruz Jr R, Abu-Elmagd K. Surgical shunt versus TIPS for treatment of variceal hemorrhage in the current era of liver and multivisceral transplantation. Surg Clin North Am. 2010;90(4):891–905.

    Article  PubMed  Google Scholar 

  25. Orloff M. Fifty-three years experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in cirrhosis. JAMA Surg. 2014;149(2):155–69.

    Article  PubMed  Google Scholar 

  26. Sabri S, Saad W. Balloon-occluded retrograde transvenous obliteration (BRTO): technique and intraprocedural imaging. Semin Intervent Radiol. 2011;28(3):303–13.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Mihas A, Sanyal A. Recurrent variceal bleeding despite endoscopic and medical therapy. Gastroenterology. 2004;127(2):621–9.

    Article  PubMed  Google Scholar 

  28. Ahn S, Park S, Tak W. Prospective validation of Baveno definitions and criteria for failure to control bleeding in portal hypertension. Hepatology. 2015;61(3):1033–40.

    Article  PubMed  Google Scholar 

  29. Feldman M, Friedman L, Brandt L. Sleisenger and Fordtran’s gastrointestinal and liver disease. 9th ed. Philadelphia: Saunders Elsevier; 2012.

    Google Scholar 

  30. Escorcell A, Pavel O, Cardenas A, Morillas R, Llop E, Villanueva C, et al. Esophageal balloon tamponade vs. esophageal stent in controlling acute refractory variceal bleeding: a multicenter RCT. Hepatology. 2015. doi:10.1002/hep.28360.

    Google Scholar 

  31. Fidelman N, Kwan S, LaBerge J, Gordon R. The transjugular intrahepatic portosystemic shunt: an update. AJR Am J Roentgenol. 2012;199(4):746–55.

    Article  PubMed  Google Scholar 

  32. Sanyal AJ, Freedman A, Luketic VA, Purdum PP, Shiffman M, Tisnado J, et al. Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy. Gastroenterology. 1996;111(1):138–46.

    Article  CAS  PubMed  Google Scholar 

  33. Garcia-Pagan J, Caca K, Bureau C, Laleman W. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362(25):2370–9.

    Article  CAS  PubMed  Google Scholar 

  34. Voros D, Polydorou A, Polmeneas G, Vassilou I, Melemeni A, Chondrogiannis K, et al. Long-term results with the modified Sugiura procedure for the management of variceal bleeding: standing the test of time in the treatment of bleeding esophageal varices. World J Surg. 2012;36(3):659–66.

    Article  CAS  PubMed  Google Scholar 

  35. Henderson J, Boyer T, Kutner M, Galloway J, Rikkers L, Jeffers L, et al. Distal splenorenal shunt versus transjubular intrahepatic portal systemic shunt for variceal bleeding: a randomized trial. Gastroenterology. 2006;130(6):1643–51.

    Article  PubMed  Google Scholar 

  36. Zhang H, Li W, Ye H, Xiao Z. Long term results of the paraesophagogastric devascularization with or without esophageal transection: which is more suitable for variceal bleeding? World J Surg. 2014;38(3):2105–12.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Demetrios Tzimas M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing AG

About this chapter

Cite this chapter

Tzimas, D., Bucobo, J.C., Telem, D. (2016). Management of Esophageal Variceal Bleeding. In: Pryor, A., Pappas, T., Branch, M. (eds) Gastrointestinal Bleeding. Springer, Cham. https://doi.org/10.1007/978-3-319-40646-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-40646-6_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40644-2

  • Online ISBN: 978-3-319-40646-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics