Fuzzy Modeling for Vitamin B12 Deficiency

  • Anna WilbikEmail author
  • Saskia van Loon
  • Arjen-Kars Boer
  • Uzay Kaymak
  • Volkher Scharnhorst
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 610)


Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.


Vitamin B12 deficiency Kidney function Takagi-Sugono fuzzy inference system 



This work is partially supported by TU/e Data Science Flagship.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Anna Wilbik
    • 1
    Email author
  • Saskia van Loon
    • 2
  • Arjen-Kars Boer
    • 2
  • Uzay Kaymak
    • 1
  • Volkher Scharnhorst
    • 2
    • 3
  1. 1.Information Systems, School of Industrial EngineeringEindhoven University of TechnologyEindhovenThe Netherlands
  2. 2.Catharina Hospital, Clinical ChemistryEindhovenThe Netherlands
  3. 3.Department of Biomedical EngineeringEindhoven University of TechnologyEindhovenThe Netherlands

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