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Fuzzy Modeling for Vitamin B12 Deficiency

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Book cover Information Processing and Management of Uncertainty in Knowledge-Based Systems (IPMU 2016)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 610))

Abstract

Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.

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References

  1. Havens, T., Bezdek, J.: An efficient formulation of the improved visual assessment of cluster tendency (iVAT) algorithm. IEEE Trans. Knowl. Data Eng. 24(5), 813–822 (2012)

    Article  Google Scholar 

  2. Iqbal, N., Azar, D., Yun, Y.M., Ghausi, O., Ix, J., Fitzgerald, R.L.: Serum methylmalonic acid and holotranscobalamin-ii as markers for vitamin B12 deficiency in end-stage renal disease patients. Ann. Clin. Lab. Sci. 3(43), 243–249 (2013)

    Google Scholar 

  3. Jang, J.S.R.: ANFIS: adaptive-network-based fuzzy inference system. IEEE Trans. Syst. Man Cybern. 3(23), 665–685 (1993)

    Article  Google Scholar 

  4. Jang, J.S.R., Sun, C.T., Mizutani, E.: Neuro-Fuzzy and Soft Computing. Prentice Hall, Englewood Cliffs (1997)

    Google Scholar 

  5. Klee, G.G.: Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B12 and folate. Clin. Chem. 8(46), 1277–1283 (2000)

    Google Scholar 

  6. MathWorks: Afis function documentation. http://nl.mathworks.com/help/fuzzy/anfis.html

  7. Moelby, L., Rasmussen, K., Ring, T., Nielsen, G.: Relationship between methylmalonic acid and cobalamin in uremia. Kidney Int. 1(57), 265–273 (2000)

    Article  Google Scholar 

  8. Popescu, M., Bezdek, J., Havens, T., Keller, J.: A cluster validity framework based on induced partition dissimilarity. IEEE Trans. Cybern. 43(1), 308–320 (2013)

    Article  Google Scholar 

  9. Smelt, H., Smulders, J., Said, M., Nienhuijs, S., Boer, A.: Improving bariatric patient aftercare outcome by improved detection of a functional vitamin B12 deficiency. Obes. Surg. 11, 1–5 (2015). doi:10.1007/s11695-015-1952-8

    Article  Google Scholar 

  10. Sousa, J.M.C., Kaymak, U.: Fuzzy Decision Making in Modeling and Control, World Scientific Series in Robotics and Intelligent Systems, vol. 27. World Scientific (2002)

    Google Scholar 

  11. Wiersinga, W., de Rooij, S., Huijmans, J., Fischer, J., Hoekstra, J.: De diagnostiek van vitamine-B12-deficintie herzien. Ned. Tijdschr. Geneeskd. 149, 2789–2794 (2005)

    Google Scholar 

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Acknowledgements

This work is partially supported by TU/e Data Science Flagship.

Author information

Authors and Affiliations

  1. Information Systems, School of Industrial Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands

    Anna Wilbik & Uzay Kaymak

  2. Catharina Hospital, Clinical Chemistry, Michelangelaan 2, 5623 EJ, Eindhoven, The Netherlands

    Saskia van Loon, Arjen-Kars Boer & Volkher Scharnhorst

  3. Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands

    Volkher Scharnhorst

Authors
  1. Anna Wilbik
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  2. Saskia van Loon
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  3. Arjen-Kars Boer
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  4. Uzay Kaymak
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  5. Volkher Scharnhorst
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Corresponding author

Correspondence to Anna Wilbik .

Editor information

Editors and Affiliations

  1. INESC-ID,Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

    Joao Paulo Carvalho

  2. LIP 6, Université Pierre et Marie Curie, Paris, France

    Marie-Jeanne Lesot

  3. School of Industrial Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    Uzay Kaymak

  4. IDMEC,Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

    Susana Vieira

  5. LIP6, Université Pierre et Marie Curie, CNRS, Paris, France

    Bernadette Bouchon-Meunier

  6. Machine Intelligence Institute, Iona College, New Rochelle, New York, USA

    Ronald R. Yager

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© 2016 Springer International Publishing Switzerland

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Wilbik, A., van Loon, S., Boer, AK., Kaymak, U., Scharnhorst, V. (2016). Fuzzy Modeling for Vitamin B12 Deficiency. In: Carvalho, J., Lesot, MJ., Kaymak, U., Vieira, S., Bouchon-Meunier, B., Yager, R. (eds) Information Processing and Management of Uncertainty in Knowledge-Based Systems. IPMU 2016. Communications in Computer and Information Science, vol 610. Springer, Cham. https://doi.org/10.1007/978-3-319-40596-4_39

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  • DOI: https://doi.org/10.1007/978-3-319-40596-4_39

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40595-7

  • Online ISBN: 978-3-319-40596-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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