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Beneficial Effect of Long-Chain Omega-3 Fatty Acids in Psoriasis

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Abstract

Psoriasis is a multifaceted autoimmune disorder associated with irregularities in the T-cell function. Activation of T-cell produces enriches amounts of biomarkers which are highly responsible for keratinocyte hyperproliferation in psoriasis. Among the diverse drug therapies available for treatment and management of psoriasis, administration of omega (ω) - 3 fatty acids (i.e., EPA and DHA) and their metabolites as alone or combination with other antipsoriatic drugs in dose-dependent manner results to inhibit proinflammatory mediators. Despites their potential benefits, these bioactive are associated with limitations like lipid peroxidation and improper bioavailability after oral and topical administration. To overcome these hiccups, emergence of nanomedicines has gained wider attention owing to their improved stability, optimum bioavailability and better efficacy against psoriasis treatment.

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Authors and Affiliations

  1. Abhilashi College of Pharmacy, Ner Chowk, Tanda, Mandi, Himachal Pradesh, India

    Mahfoozur Rahman

  2. Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (SHIATS), Allahabad, India

    Mahfoozur Rahman & Vikas Kumar

  3. UIPS, Panjab University, Chandigarh, India

    Sarwar Beg

  4. F/O, Science, Department of Biochemistry, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia

    Firoz Anwar

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  4. Vikas Kumar
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Correspondence to Vikas Kumar .

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  1. Real Nutrition Laboratory, Bharati Vidyapeeth University Real Nutrition Laboratory, Dhankawadi, India

    Mahabaleshwar V. Hegde

  2. Center for Innovation in Nutrition Health Disease, Bharati Vidyapeeth University , Dhankawadi Pune, India

    Anand Arvind Zanwar

  3. Western IRB Medical Vice Chair, Puyallup, Washington, USA

    Sharad P. Adekar

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Rahman, M., Beg, S., Anwar, F., Kumar, V. (2016). Beneficial Effect of Long-Chain Omega-3 Fatty Acids in Psoriasis. In: Hegde, M., Zanwar, A., Adekar, S. (eds) Omega-3 Fatty Acids. Springer, Cham. https://doi.org/10.1007/978-3-319-40458-5_38

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