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Influence of Omega-3 Fatty Acids on Bone Turnover

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Omega-3 Fatty Acids

Abstract

Bone is a metabolically active tissue that undergoes continuous remodeling to cope with the body’s Ca and P requirements and to repair microscopic damage in a dynamic process where osteoblasts are responsible for bone formation and osteoclasts for its resorption. Dietary fat has a clear influence on bone health. Long-chain polyunsaturated fatty acids (LC-PUFAs), especially the omega-3 (ω-3) fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial for bone metabolism. Several studies have reported that LC-PUFAs can increase bone formation, affecting peak bone mass in adolescents and reducing bone loss, because LC-PUFAs reduce inflammatory cytokines, increases calcium absorption, and enhances skeletal calcium levels. This chapter summarizes the role of LC-PUFA, especially the ω-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid, on bone health and turnover.

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Authors and Affiliations

  1. Institute of Nutrition and Food Technology “José Mataix Verdú”, Biomedical Research Center, Health Sciences Technological Park, University of Granada, 18071, Granada, Spain

    Javier Díaz-Castro, Naroa Kajarabille, Mario Pulido-Morán, Jorge Moreno-Fernández, Magdalena López-Frías & Julio J. Ochoa

  2. Department of Physiology, Faculty of Pharmacy, University of Granada, Campus de Cartuja, s/n, 18071, Granada, Spain

    Javier Díaz-Castro, Naroa Kajarabille, Jorge Moreno-Fernández, Magdalena López-Frías & Julio J. Ochoa

  3. Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Campus de Cartuja, s/n, 18071, Granada, Spain

    Mario Pulido-Morán

  4. Departament of Physiology and Institute of Nutrition and Food Technology, Biomedical Research Center, Health Sciences Technological Park, University of Granada, Avenida del Conocimiento s/n, Armilla, 18071, Granada, Spain

    Julio J. Ochoa

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  1. Javier Díaz-Castro
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  2. Naroa Kajarabille
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  3. Mario Pulido-Morán
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  5. Magdalena López-Frías
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Correspondence to Julio J. Ochoa .

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Editors and Affiliations

  1. Real Nutrition Laboratory, Bharati Vidyapeeth University Real Nutrition Laboratory, Dhankawadi, India

    Mahabaleshwar V. Hegde

  2. Center for Innovation in Nutrition Health Disease, Bharati Vidyapeeth University , Dhankawadi Pune, India

    Anand Arvind Zanwar

  3. Western IRB Medical Vice Chair, Puyallup, Washington, USA

    Sharad P. Adekar

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Díaz-Castro, J., Kajarabille, N., Pulido-Morán, M., Moreno-Fernández, J., López-Frías, M., Ochoa, J.J. (2016). Influence of Omega-3 Fatty Acids on Bone Turnover. In: Hegde, M., Zanwar, A., Adekar, S. (eds) Omega-3 Fatty Acids. Springer, Cham. https://doi.org/10.1007/978-3-319-40458-5_23

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  • DOI: https://doi.org/10.1007/978-3-319-40458-5_23

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