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Cardiovascular Structure, Function, and Pathophysiology

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Cardiovascular Safety in Drug Development and Therapeutic Use

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Abstract

This chapter provides an overview of healthy cardiovascular structure and function, followed by an overview of cardiac pathophysiology and disease. In each case, attention falls first on the heart, since multiple subsequent chapters focus on proarrhythmia. Nonetheless, discussions of the cardiovascular system are also pertinent to topics addressed later in the book.

The heart is a supreme example of biomechanical engineering that, under normal circumstances, operates with elegant economy (Turner 1994).

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Authors and Affiliations

  1. Cardiac Safety Services Quintiles, Durham, North Carolina, USA

    J. Rick Turner (Chief Scientific Advisor)

  2. Research Team, Cardiac Safety Services Quintiles, Mumbai, India

    Dilip R. Karnad (Head)

  3. Cardiac Safety Services Global Head, Cardiac Safety Center of Excellence Quintiles, Mumbai, India

    Snehal Kothari (Chief Medical & Scientific Officer)

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  1. J. Rick Turner
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Turner, J.R., Karnad, D.R., Kothari, S. (2017). Cardiovascular Structure, Function, and Pathophysiology. In: Cardiovascular Safety in Drug Development and Therapeutic Use. Adis, Cham. https://doi.org/10.1007/978-3-319-40347-2_3

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