Blood Pressure Responses to Noncardiovascular Drugs in Development and Therapeutic Use

  • J. Rick Turner
  • Dilip R. Karnad
  • Snehal Kothari
Chapter

Abstract

This chapter focuses on unintended drug-induced blood pressure responses. While both increases and decreases are legitimate areas of investigation (Kane-Gill et al. 2014; Kennelly and Esaian 2013), our attention falls on increases. As was noted in Sect.  3.4.4, high blood pressure is authoritative regarded as the greatest threat to the global burden of disease (Horton 2013; Das and Samarasekera 2013; Lim et al. 2013). As hypertension has been studied across several decades, we have learned that there are multiple ways in which increased blood pressure may occur (see Frohlich 1977; Page 1982; Dustan 1990; Harrison 2013). It has now also become clear that noncardiovascular drugs can lead to off-target increases in blood pressure and can also do so via a variety of mechanisms of action. As Grossman and Messerli (2012) observed, “Some agents cause either sodium retention or extracellular volume expansion, or activate directly or indirectly the sympathetic nervous system. Other substances act directly on arteriolar smooth muscle or do not have a defined mechanism of action. Some medications that usually lower BP may paradoxically increase BP, or an increase in pressure may be encountered after their discontinuation.”

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • J. Rick Turner
    • 1
  • Dilip R. Karnad
    • 2
  • Snehal Kothari
    • 3
  1. 1.Cardiac Safety Services QuintilesDurhamUSA
  2. 2.Research TeamCardiac Safety Services QuintilesMumbaiIndia
  3. 3.Cardiac Safety Services Global HeadCardiac Safety Center of Excellence QuintilesMumbaiIndia

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