Oncology Drug Therapy: Cardiotoxicity and the Discipline of Cardio-oncology

  • J. Rick Turner
  • Dilip R. Karnad
  • Snehal Kothari


The three preceding chapters, which comprise Part IV of this book, discussed topics falling within the domain of proarrhythmic cardiac safety. As we move into Part V, attention now broadens to other domains within the field of cardiovascular safety. This chapter addresses cardiotoxicity considerations in the therapeutic use of oncologic agents. The construct and employment of benefit–risk assessments have been discussed in several contexts in previous chapters. As we move into discussions related to the therapeutic use of drugs that have received marketing approval, the observation by Garattini (2010) that “drug authorization, prescription, and utilization are all based on benefit-risk assessment” provides an integrated perspective on this topic.


Left Ventricular Ejection Fraction Arsenic Trioxide Oncologic Drug Cardiovascular Damage Receive Marketing Approval 
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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • J. Rick Turner
    • 1
  • Dilip R. Karnad
    • 2
  • Snehal Kothari
    • 3
  1. 1.Cardiac Safety Services QuintilesDurhamUSA
  2. 2.Research TeamCardiac Safety Services QuintilesMumbaiIndia
  3. 3.Cardiac Safety Services Global HeadCardiac Safety Center of Excellence QuintilesMumbaiIndia

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