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Histamine Function in Nervous Systems

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Book cover Histamine Receptors

Part of the book series: The Receptors ((REC,volume 28))

Abstract

Histamine is evolutionarily highly conserved as a signaling molecule, a neuromodulator, and a neurotransmitter from bacteria to mammals that fulfills basic demands of living like the organization of behavioral state. From mussels to mammals, it gates ion channels like classical ionotropic transmitters. These relatively neglected functions are treated for arthropods and mollusks. In vertebrate brains, histamine actions are mostly mediated by three of the four known G-protein-coupled receptors: H1R, H2R, and H3R. Histamine also modifies other receptor proteins through allosteric interactions. We describe and discuss the anatomical, biophysical, and physiological properties of histaminergic neurons as well as their projections and actions on target neurons.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Neuro- and Sensory Physiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40205, Germany

    Olga A. Sergeeva Ph.D. & Helmut L. Haas M.D.

  2. Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University Düsseldorf, Düsseldorf, 40205, Germany

    Olga A. Sergeeva Ph.D.

Authors
  1. Olga A. Sergeeva Ph.D.
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  2. Helmut L. Haas M.D.
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Correspondence to Helmut L. Haas M.D. .

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Editors and Affiliations

  1. Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA) – Sezione di Farmacologia e Tossicologia, Università degli Studi di Firenze, Florence, Italy

    Patrizio Blandina

  2. Dipartimento di Scienze della Salute – Sezione di Farmacologia Clinica e Oncologia, Università degli Studi di Firenze, Florence, Italy

    Maria Beatrice Passani

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Sergeeva, O.A., Haas, H.L. (2016). Histamine Function in Nervous Systems. In: Blandina, P., Passani, M. (eds) Histamine Receptors. The Receptors, vol 28. Humana, Cham. https://doi.org/10.1007/978-3-319-40308-3_9

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