Abstract
What’s “best” for the cancer, may not always be “best” for the patient. This is particularly true for T2 rectal cancer; more specifically for patients with rectal cancer. More radical treatments may in certain circumstances, result in higher disease free survival, but not in improvements in overall survival, and certainly not a better functional result or enhanced quality of life. In selecting treatment options one must understand multiple important factors regarding the tumor and the patient in whom it resides.
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References
Dieguez A. Rectal cancer staging: focus on the prognostic significance of the findings described by high-resolution magnetic resonance imaging. Cancer Imaging. 2013;13(2):277–97.
Sr P, Bechtold ML, Reddy JB, Choudhary A, et al. How god is endoscopic ultrasound in differentiating various T stages of rectal cancer? Meta-analysis and systematic review. Ann Surg Oncol. 2009;16(2):254–65.
Brown G, Richards CJ, Bourne MW, et al. Morphologic predictors of lymph node status in rectal cancer with use of high spatial-resolution MR imaging with histopathologic comparison. Radiology. 2003;227:371–7.
Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG. High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol. 2004;52:78–83.
Nagpal K, Bennett N. Colorectal surgery and its impact on male sexual function. Curr Urol Rep. 2013;14:279–84.
Ho VP, Lee Y, Stein SL, Temple LK. Sexual function after treatment for rectal cancer: a review. Dis Colon Rectum. 2011;54:113–25.
Moriya Y. Function preservation in rectal cancer surgery. Int J Clin Oncol. 2006;11:339–43.
Bruheim K, Guren MG, Skovlund E, Hjermstad MJ, et al. Late side effects and quality of life after radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys. 2010;76(4):1005–11.
Ball M, Nelson CJ, Shuk E, Starr TD, et al. Men’s experience with sexual dysfunction post-rectal cancer treatment: a qualitative study. J Cancer Educ. 2013;28:494–502.
Lezoche G, Baldarelli M, Guerrieri M, Paganini AM, et al. A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy. Surg Endosc. 2008;22(2):352–8.
You YN, Baxter NN, Stewart A, Nelson H. Is the increasing rate of local excision for Stage I rectal cancer in the United States justisfied? A nationwide cohort study from the National Cancer Database. Ann Surg. 2007;245(5):726–33.
Hazard LJ, Sklow B, Pappas L, Boucher KM, et al. Local excision vs. radical resection in T1-2 rectal carcinoma: results of a study from the surveillance, epidemiology, and end results (SEER) registry data. Gastrointest Cancer Res. 2009;3(3):105–14.
Moore JS, Cataldo PA, Osler T, Hyman NH. Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Dis Colon Rectum. 2008;51(7):1026–30.
Guerrieri M, Ortenzi M, Cappelletti Trombettoni MM, Kubolli I, et al. Local excision of early rectal cancer by transanal endoscopic microsurgery (TEM): The 23-year experience of a single centre. J Cancer Ther. 2015;6(11):1000–7.
Habr-Gama A, Gama-Rodrigues J, São Julião P, Proscurshim I, et al. Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control. Int J Radiat Oncol Biol Phys. 2014;88(4):822–8.
Habr-Gama A, Perez RO, Nadalin W, Sabbago J, et al. Operative versus nonoperative treatment for Stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg. 2004;240(4):711–8.
Han JG, Wang ZJ, Wei GH, Gao ZG, Yang Y, Zhao BC, et al. Randomized clinical trial of conventional versus cylindrical abdominoperineal resection for locally advanced lower rectal cancer. Am J Surg. 2012;204(3):274–82.
Garcia-Aguilar J, Renfro LA, Chow OS, Shi Q, et al. Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local exicision (ACOSOG Z6041): results of an open-label, single-arm multi-institutional, phase 2 trial. Lancet. 2015;16:1537–46.
Stockholm Rectal Cancer Study Group. Preoperative short-term radiation therapy in operable rectal carcinoma: a prospective randomized trial. Cancer. 1990;66:49–55.
Sauer R, Liersch T, Merkel S, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012;30(16):1926–33.
Kapiteeijn E, Marijnen CAM, Nagtegaal ID, Putter H, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345(9).
Peeters KCMJ, Marijnen AM, Nagtegaal ID, Kranenbarg EK, et al. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246(5):693–701.
Chen Y, Liu Z, Zhu K, et al. Transanal endoscopic microsurgery versus laparoscopic lower anterior resection for the treatment of T1–2 rectal cancers. Hepato-gastroenterology. 2013;60:727–32.
Yu CS, Yun HR, Shin EJ, et al. Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis. Am J Surg. 2013;206:482–7.
Appelt AL, PlØen J, Harling H, et al. High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study. Lancet. 2015;16(8):919–27.
Smith JD, Ruby JA, Goodman KA, et al. Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy. Ann Surg. 2012;256(6):965–72.
Maas M, Beets-Tan R, Lambregets D, et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol. 2011;29(35):4633–40.
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Cataldo, P.A. (2017). Management of T2 Rectal Cancer. In: Hyman, N., Umanskiy, K. (eds) Difficult Decisions in Colorectal Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-319-40223-9_18
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DOI: https://doi.org/10.1007/978-3-319-40223-9_18
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