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Evidence-Based Review of the Use of Steroids in Neurotrauma

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Neurotrauma Management for the Severely Injured Polytrauma Patient

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Abstract

Traumatic brain injury is a leading cause of premature death and disability in the world. Post-traumatic inflammation and edema is poorly tolerated by the central nervous system and exacerbates neurologic deterioration. Local release of cytotoxic inflammatory mediations results in secondary injury and worsening clinical outcomes. To reduce post-traumatic inflammation, steroids have been investigated and used as a preventative measure. This chapter reviews the most up-to-date literature on steroid use for the treatment of traumatic brain and spinal cord injury as well as traumatic cranial neuropathies and make recommendations on its role in modern clinical practice.

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Authors and Affiliations

  1. Department of Neurosurgery, UW Hospital and Clinics, 600 Highland Ave K4/822, Madison, WI, 53792, USA

    Yiping Li, Kimberly Hamilton & Joshua Medow

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  1. Yiping Li
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  2. Kimberly Hamilton
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  3. Joshua Medow
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Correspondence to Joshua Medow .

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Editors and Affiliations

  1. Neuroscience Department, Inova Neuroscience Institute Inova Fairfax Medical Campus, Falls Church, Virginia, USA

    James M. Ecklund

  2. Pediatric Neurosciences, Inova Neuroscience Institute, Falls Church, Virginia, USA

    Leon E. Moores

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Li, Y., Hamilton, K., Medow, J. (2017). Evidence-Based Review of the Use of Steroids in Neurotrauma. In: Ecklund, J., Moores, L. (eds) Neurotrauma Management for the Severely Injured Polytrauma Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-40208-6_9

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  • DOI: https://doi.org/10.1007/978-3-319-40208-6_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40206-2

  • Online ISBN: 978-3-319-40208-6

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