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Ageing and Senescence in Mesenchymal Stem Cells

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Stem Cell Processing

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

An overlooked aspect in modern medical research is the effects of donor age in the use of stem cells. Several aspects as noted to include proliferative rate and capacity, early senescence and differentiation. Discovery of genetic and signalling pathways influencing these problems have been emerging over the last few years, including oncogenes. Furthermore, there are emerging studies to overcome these known difficulties using stem cells from older populations, and there have been developments in established protocols for chondrogenic, osteogenic and adipogenic differentiation that we outline.

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Author information

Authors and Affiliations

  1. University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, UK

    Hitesh D. Tailor

  2. Department of Trauma & Orthopaedics, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, TR1 3LQ, UK

    Yiannis Pengas

  3. Division of Trauma & Orthopaedics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

    Wasim S. Khan

Authors
  1. Hitesh D. Tailor
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  2. Yiannis Pengas
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  3. Wasim S. Khan
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Editor information

Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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© 2016 Springer International Publishing Switzerland

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Tailor, H.D., Pengas, Y., Khan, W.S. (2016). Ageing and Senescence in Mesenchymal Stem Cells. In: Pham, P. (eds) Stem Cell Processing . Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40073-0_3

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