Abstract
Programmed cell death changes and loss of cell growth and anti-growth regulation signals may result in uncontrolled cell proliferation, disorganized tissue growth and tumor formation. Malignant solid tumors, i.e. lung and brain tumors, are one of the most common and the most serious diseases nowadays and therefore considered a major issue in modern medicine. Despite intensive progress in cancer research, the survival rate of patients with diagnosed malignant solid tumors hasn’t improved significantly. Radiotherapy and chemotherapy work predominantly by inducing apoptosis. The purpose of this article is to describe the role of apoptosis and to review currently known agents that allow induction of apoptosis in cancer cells. The identification of potential new targets for tumor treatment and processes in altered tumor cell metabolism is the challenging area of research. Recognizing the attributes of malignant tumor growth inhibition may help in the development of novel treatment strategies.
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References
Blahovcová, E., Richterová, R., Kolarovski, B., Dobrota, D., Račay, P., Hatok. J.: Apoptosis-related gene expression in tumor tissue samples obtained from patients diagnosed with glioblastoma multiforme. Int. J. Mol. Med. 36, 1677–1684 (2015)
Caruso, G., Caffo, M.: Antisense oligonucleotides in the treatment of cerebral gliomas. Review of concerning patents. Recent Pat. CNS Drug Discov. 1, 2–12 (2014)
Chen, D.J., Huerta, S.: Smac mimetics as next cancer therapeutics. Anti-Cancer Drugs 20, 646–658 (2009)
Chen, S., Dai, Y., Harada, H., Dent, P., Grant, S.: Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res. 67, 782–791 (2007)
Cohen, N.A., Stewart, M.L., Gavathiotism, E., Tepper, J.L., Bruekner, S.R., Koss, B., Opferman, J.T., Walensky, L.D.: A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem. Biol. 19, 1175–1186 (2012)
Crooke, S.T.: Molecular mechanism of antisense drugs: RNAseH. Antisense Nucleic Acid Drug Dev. 8, 133–134 (1998)
Dalafave, D.S., Prisco, G.: Inhibition of antiapoptotic BCL-XL, BCL-2, and MCL-1 proteins by small molecule mimetics. Cancer Inform. 9, 169–177 (2010)
Dean, E.M., Ranson, M., Blackhall, F., Holt, S.V., Dive, C.: Novel therapeutic targets in lug cancer: inhibitor of apoptosis proteins from laboratory to clinic. Cancer Treat. Rev. 33, 203–212 (2007)
Degterev, A., Lugovskoy, A., Cardone, M., Mulley, B., Wagner, G., Mitchison, T., Yuan, J.: Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xl. Nat. Cell Biol. 3, 173–182 (2001)
Galluzzi, L., Zamzami, N., de La, Motte Rouge, T., Lemaire, C., Brenner, C., Kroemer, G.: Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis 12, 803–813 (2007)
Ghavami, S., Hashemi, M., Ande, S.R., Yeganeh, B., Xiao, W., Eshraghi, M., Bus, C.J., Kadkhoda, K., Wiechec, E., Halayko, A.J., Los, M.: Apoptosis and cancer: mutations within caspase genes. Am. J. Med. Genet. 46, 497–510 (2009)
Gkogkou, Ch., Frangia, K., Saif, M.W., Trigidou, R., Syrigos, K.: Necrosis and apoptotic index as prognostic factors in non-small cell lung carcinoma: a review. Springerplus 3, 120 (2014). doi:10.1186/2193-1801-3-120
Hanahan, D., Weinberg, R.A.: Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011)
Hann, ChL, Daniel, V.C., Sugar, E.A., et al.: Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer. Cancer Res. 68, 2321–2328 (2008)
Kang, M.H., Reynolds, C.P.: Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin. Cancer Res. 15, 1126–1132 (2009)
Kelly, G., Strasser, A.: The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ. 18, 1414–1424 (2011)
Kim, E.H., Kim, H.S., Kim, S.U., Noh, E.J., Lee, J.S., Choi, K.S.: Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. Oncogene 46, 6877–6889 (2005)
Kuendgen, A., Lübbert, M.: Current status of epigenetic treatment in myelodysplastic syndromes. Ann. Hematol. 8, 601–611 (2008)
La Casse, E.C., Baird, S., Korneluk, R.G., MacKenzie, A.E.: The inhibitors of apoptosis IAPs and their emerging role in cancer. Oncogene 17, 3247–3259 (1998)
Li, R.Y., Chen, LCh., Zhang, H.Y., Du, W.Z., Feng, Y., Wang, H.B., Wen, J.Q., Liu, X., Li, X.F., Sun, Y., Yang, D.B., Jiang, T., Li, Y.L., Jiang, ChL: MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci. Ther. 19, 477–483 (2013)
Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., et al.: An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677–681 (2005)
Portt, L., Norman, G., Clapp, C., Greenwood, M., Greenwood, M.T.: Anti-apoptosis and cell survival: a review. Biochim. Biophys. Acta 1813, 238–259 (2011)
Račay, P., Jurečeková, J., Štefániková, A., Kliková, K., Hatok, J., Dobrota, D.: Bcl-2 family proteins in development and treatment of malignant diseases. Acta Medica Martiniana 11, 15–23 (2011)
Sayers, T.J.: Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol. Immunother. 60, 1173–1180 (2011)
Schimmer, A.D., Dalili, S., Batey, R.A., Riedl, S.J.: Targeting XIAP for the treatment of malignancy. Cell Death Differ. 13, 179–188 (2006)
Schmitt, E., Pacquet, C., Beauchemin, M., Bertrand, R.: DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J. Zhejiang Uni. Sci. B. 8, 377–397 (2007)
Sekimura, A., Konishi, A., Mizuno, K., Kobayashi, Y., Sasaki, H., Yano, M., Fukai, I., Fujii, Y.: Expression of Smac/DIABLO is a novel prognostic marker in lung cancer. Oncol. Rep. 11, 797–802 (2004)
Shi, Y.: Mechanisms of caspase activation and activation and inhibition during apoptosis. Mol. Cell. 9, 459–470 (2002)
Tahir, S.K., Yang, X., Anderson, M.G., Morgan-Lappe, S.E., Sarthy, A.V., Chen, J., Warner, R.B., Ng, S.C., Fesik, S.W., Elmore, S.W., Rosenberg, S.H., Tse, C.: Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res. 67, 1176–1183 (2007)
Thomas, S., Quinn, B.A., Das, S.K., Dash, R., Emdad, L., Dasgupta, S., Wang, X.Y., Dent, P., Reed, J.C., Pellecchia, M., Sarkar, D., Fisher, P.B.: Targeting the Bcl-2 family for cancer therapy. Expert Opin. Ther. Targets 17, 61–75 (2013)
Tse, C., Shoemaker, A.R., Adickes, J., et al.: ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 9, 3421–3428 (2008)
Vaux, D.L.: Caspases and apoptosis—biology and terminology. Cell Death Difer. 6, 493–494 (1999)
Verhagen, A.M., Coulson, E.J., Vaux, D.L.: Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol. 2, REVIEWS3009 (2001)
Vogler, M.: Targeting BCL2 proteins for the treatment of solid tumours. Adv. Med. 2014, 943648 (2014). doi:10.1155/2014/943648
Westhoff, M.A., Brühl, O., Nonnenmacher, L., Karpel-Massler, G., Debatin, K.M.: Killing me softly - future challenges in apoptosis research. Int. J. Mol. Sci. 15, 3746–3767 (2014)
Zubor, P., Hatok, J., Moricova, P., Kajo, K., Kapustova, I., Mendelova, A., Racay, P., Danko, J.: Gene expression abnormalities in histologically normal breast epithelium from patients with luminal type of breast cancer. Mol. Biol. Rep. 42, 977–988 (2015)
Acknowledgments
This work was supported by Ministry of Health of the Slovak Republic under the contract MZ SR 2012/25-UKMA-2, by the project Competence Center for Research and Development in the Field of Diagnostics and Therapy of Oncological Diseases, ITMS: 26220220153 and by the project “Biomedical Center Martin” ITMS code: 26220220187, the project is co-financed from EU sources.
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Blahovcová, E., Škovierová, H., Strnádel, J., Mištuna, D., Halašová, E. (2016). Apoptosis in Cancer Cells. In: Piętka, E., Badura, P., Kawa, J., Wieclawek, W. (eds) Information Technologies in Medicine. ITiB 2016. Advances in Intelligent Systems and Computing, vol 472. Springer, Cham. https://doi.org/10.1007/978-3-319-39904-1_18
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