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Epidemiology and Etiology of Childhood ALL

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Book cover Childhood Acute Lymphoblastic Leukemia

Abstract

Despite extensive research, the etiology of childhood acute lymphoblastic leukemia (ALL) remains largely unknown. There is growing evidence that childhood ALL arises from in utero chromosomal abnormalities that can lead to clonal expansion of pre-leukemic precursor cells. The risk factors for ALL in children are multiple, most notably common germline polymorphisms and rare genetic syndromes that directly influence hematopoiesis and cell cycling, as well as infection-related aberrant DNA editing.

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Authors and Affiliations

  1. Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark

    Morten Tulstrup, Ulrik Kristoffer Stoltze & Kjeld Schmiegelow

  2. Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

    Kjeld Schmiegelow

  3. Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Jun J. Yang

Authors
  1. Morten Tulstrup
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  2. Ulrik Kristoffer Stoltze
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  3. Kjeld Schmiegelow
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  4. Jun J. Yang
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Corresponding author

Correspondence to Jun J. Yang .

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Editors and Affiliations

  1. Department of Paediatric Haemotology, Sheffield Children’s Hospital NHS Trust, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

    Ajay Vora

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Tulstrup, M., Stoltze, U.K., Schmiegelow, K., Yang, J.J. (2017). Epidemiology and Etiology of Childhood ALL. In: Vora, A. (eds) Childhood Acute Lymphoblastic Leukemia. Springer, Cham. https://doi.org/10.1007/978-3-319-39708-5_1

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  • DOI: https://doi.org/10.1007/978-3-319-39708-5_1

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